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IR@PKUHSC  > 北京大学口腔医学院  > 口腔颌面外科  > 期刊论文
学科主题: 口腔医学
题名:
Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease
作者: Wang, Jinfeng1; Qi, Ji2; Zhao, Hui1; He, Shu3; Zhang, Yifei3; Wei, Shicheng3; Zhao, Fangqing1
刊名: SCIENTIFIC REPORTS
发表日期: 2013-05-15
DOI: 10.1038/srep01843
卷: 3
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: BLACK-PIGMENTED BACTEROIDES ; VIRULENCE FACTORS ; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS ; PORPHYROMONAS-GINGIVALIS ; ORAL-CAVITY ; HEALTH ; IDENTIFICATION ; GENE ; CHEMOTAXIS ; DIVERSITY
英文摘要:

Although attempts have been made to reveal the relationships between bacteria and human health, little is known about the species and function of the microbial community associated with oral diseases. In this study, we report the sequencing of 16 metagenomic samples collected from dental swabs and plaques representing four periodontal states. Insights into the microbial community structure and the metabolic variation associated with periodontal health and disease were obtained. We observed a strong correlation between community structure and disease status, and described a core disease-associated community. A number of functional genes and metabolic pathways including bacterial chemotaxis and glycan biosynthesis were over-represented in the microbiomes of periodontal disease. A significant amount of novel species and genes were identified in the metagenomic assemblies. Our study enriches the understanding of the oral microbiome and sheds light on the contribution of microorganisms to the formation and succession of dental plaques and oral diseases.

语种: 英语
所属项目编号: NSFC 91131013 ; 0869011BJ5 ; 31100094 ; 30973317
项目资助者: National Natural Science Foundation of China ; CAS ; NSFC
WOS记录号: WOS:000318893700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52635
Appears in Collections:北京大学口腔医学院_口腔颌面外科_期刊论文

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作者单位: 1.Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China
2.Fudan Univ, Sch Life Sci, Inst Plant Biol, Shanghai 200433, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Lab Interdisciplinary Studies, Beijing 100081, Peoples R China

Recommended Citation:
Wang, Jinfeng,Qi, Ji,Zhao, Hui,et al. Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease[J]. SCIENTIFIC REPORTS,2013,3.
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