IR@PKUHSC  > 北京大学口腔医学院  > 口腔颌面外科
学科主题口腔医学
Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease
Wang, Jinfeng1; Qi, Ji2; Zhao, Hui1; He, Shu3; Zhang, Yifei3; Wei, Shicheng3; Zhao, Fangqing1
刊名SCIENTIFIC REPORTS
2013-05-15
DOI10.1038/srep01843
3
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者National Natural Science Foundation of China ; CAS ; NSFC ; National Natural Science Foundation of China ; CAS ; NSFC
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]BLACK-PIGMENTED BACTEROIDES ; VIRULENCE FACTORS ; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS ; PORPHYROMONAS-GINGIVALIS ; ORAL-CAVITY ; HEALTH ; IDENTIFICATION ; GENE ; CHEMOTAXIS ; DIVERSITY
英文摘要

Although attempts have been made to reveal the relationships between bacteria and human health, little is known about the species and function of the microbial community associated with oral diseases. In this study, we report the sequencing of 16 metagenomic samples collected from dental swabs and plaques representing four periodontal states. Insights into the microbial community structure and the metabolic variation associated with periodontal health and disease were obtained. We observed a strong correlation between community structure and disease status, and described a core disease-associated community. A number of functional genes and metabolic pathways including bacterial chemotaxis and glycan biosynthesis were over-represented in the microbiomes of periodontal disease. A significant amount of novel species and genes were identified in the metagenomic assemblies. Our study enriches the understanding of the oral microbiome and sheds light on the contribution of microorganisms to the formation and succession of dental plaques and oral diseases.

语种英语
所属项目编号NSFC 91131013 ; 0869011BJ5 ; 31100094 ; 30973317
资助者National Natural Science Foundation of China ; CAS ; NSFC ; National Natural Science Foundation of China ; CAS ; NSFC
WOS记录号WOS:000318893700001
Citation statistics
Cited Times:66[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52635
Collection北京大学口腔医学院_口腔颌面外科
作者单位1.Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China
2.Fudan Univ, Sch Life Sci, Inst Plant Biol, Shanghai 200433, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Lab Interdisciplinary Studies, Beijing 100081, Peoples R China
Recommended Citation
GB/T 7714
Wang, Jinfeng,Qi, Ji,Zhao, Hui,et al. Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease[J]. SCIENTIFIC REPORTS,2013,3.
APA Wang, Jinfeng.,Qi, Ji.,Zhao, Hui.,He, Shu.,Zhang, Yifei.,...&Zhao, Fangqing.(2013).Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease.SCIENTIFIC REPORTS,3.
MLA Wang, Jinfeng,et al."Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease".SCIENTIFIC REPORTS 3(2013).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Wang, Jinfeng]'s Articles
[Qi, Ji]'s Articles
[Zhao, Hui]'s Articles
百度学术
百度学术Similar articles in
[Wang, Jinfeng]'s Articles
[Qi, Ji]'s Articles
[Zhao, Hui]'s Articles
必应学术
必应学术Similar articles in
[Wang, Jinfeng]'s Articles
[Qi, Ji]'s Articles
[Zhao, Hui]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.