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学科主题口腔医学
Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease
Wang, Jinfeng1; Qi, Ji2; Zhao, Hui1; He, Shu3; Zhang, Yifei3; Wei, Shicheng3; Zhao, Fangqing1
刊名SCIENTIFIC REPORTS
2013-05-15
DOI10.1038/srep01843
3
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]BLACK-PIGMENTED BACTEROIDES ; VIRULENCE FACTORS ; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS ; PORPHYROMONAS-GINGIVALIS ; ORAL-CAVITY ; HEALTH ; IDENTIFICATION ; GENE ; CHEMOTAXIS ; DIVERSITY
英文摘要

Although attempts have been made to reveal the relationships between bacteria and human health, little is known about the species and function of the microbial community associated with oral diseases. In this study, we report the sequencing of 16 metagenomic samples collected from dental swabs and plaques representing four periodontal states. Insights into the microbial community structure and the metabolic variation associated with periodontal health and disease were obtained. We observed a strong correlation between community structure and disease status, and described a core disease-associated community. A number of functional genes and metabolic pathways including bacterial chemotaxis and glycan biosynthesis were over-represented in the microbiomes of periodontal disease. A significant amount of novel species and genes were identified in the metagenomic assemblies. Our study enriches the understanding of the oral microbiome and sheds light on the contribution of microorganisms to the formation and succession of dental plaques and oral diseases.

语种英语
WOS记录号WOS:000318893700001
项目编号NSFC 91131013 ; 0869011BJ5 ; 31100094 ; 30973317
资助机构National Natural Science Foundation of China ; CAS ; NSFC
引用统计
被引频次:77[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52635
专题北京大学口腔医学院_口腔颌面外科
北京大学口腔医学院_中心实验室
作者单位1.Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China
2.Fudan Univ, Sch Life Sci, Inst Plant Biol, Shanghai 200433, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Lab Interdisciplinary Studies, Beijing 100081, Peoples R China
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GB/T 7714
Wang, Jinfeng,Qi, Ji,Zhao, Hui,et al. Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease[J]. SCIENTIFIC REPORTS,2013,3.
APA Wang, Jinfeng.,Qi, Ji.,Zhao, Hui.,He, Shu.,Zhang, Yifei.,...&Zhao, Fangqing.(2013).Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease.SCIENTIFIC REPORTS,3.
MLA Wang, Jinfeng,et al."Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease".SCIENTIFIC REPORTS 3(2013).
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