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Photodegradable Polyurethane Self-Assembled Nanoparticles for Photocontrollable Release
Lv, Cong; Wang, Zhen; Wang, Peng; Tang, Xinjing
刊名LANGMUIR
2012-06-26
DOI10.1021/la301534h
28期:25页:9387-9394
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
研究领域[WOS]Chemistry ; Materials Science
关键词[WOS]DRUG-DELIVERY SYSTEMS ; BLOCK-COPOLYMER ; POLYMERIC VESICLES ; TRIGGERED RELEASE ; PHOTO ; HYDROGELS ; MICELLES ; PROTEIN ; CELLS ; MICROPARTICLES
英文摘要

Light-responsive drug delivery systems are particularly appealing that are capable of releasing active molecules at the appropriate site and rate. We synthesized a series of photodegradable polymers that can form nanoparticles for drug encapsulation. These particles in aqueous solutions are stable in buffers with different pHs or at evaluated temperatures, while light can trigger the crash of particles and the release of encapsulated substances. The release efficiency can reach up to 90% based on Nile red fluorescence intensity upon 15 min light irradiation. Nanoparticle uptake by phagocytic cells and light-triggered release in cells were observed by fluorescence emission of the hydrolyzed fluorescein diacetate upon photoinduced degradation of these nanoparticles. No significant toxicity of these nanoparticles was found at the concentrations up to 1000 mu g/mL before or after light irradiation. Further encapsulation and triggered release of a bioactive model drug (Tagalsin G) was evaluated for RAW 264.7 cells. Tagalsin G encapsulated in nanoparticles did not show cytotoxity to cells, while light triggered the release of Tagalsin G increasing cell death dramatically from 9% to 67%. Our model studies show a new promising strategy to trigger drug release in cells.

语种英语
WOS记录号WOS:000305661400027
项目编号21072015 ; NCET-10-0203 ; BMU20110263
资助机构National Science Foundation of China ; Program for New Century Excellent Talents in University ; Innovation Team of Ministry of Education
引用统计
被引频次:43[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52638
专题北京大学药学院
北京大学医学部管理机构_医学部
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
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GB/T 7714
Lv, Cong,Wang, Zhen,Wang, Peng,et al. Photodegradable Polyurethane Self-Assembled Nanoparticles for Photocontrollable Release[J]. LANGMUIR,2012,28(25):9387-9394.
APA Lv, Cong,Wang, Zhen,Wang, Peng,&Tang, Xinjing.(2012).Photodegradable Polyurethane Self-Assembled Nanoparticles for Photocontrollable Release.LANGMUIR,28(25),9387-9394.
MLA Lv, Cong,et al."Photodegradable Polyurethane Self-Assembled Nanoparticles for Photocontrollable Release".LANGMUIR 28.25(2012):9387-9394.
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