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学科主题: 药学
题名:
Photodegradable Polyurethane Self-Assembled Nanoparticles for Photocontrollable Release
作者: Lv, Cong; Wang, Zhen; Wang, Peng; Tang, Xinjing
刊名: LANGMUIR
发表日期: 2012-06-26
DOI: 10.1021/la301534h
卷: 28, 期:25, 页:9387-9394
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ; Materials Science
关键词[WOS]: DRUG-DELIVERY SYSTEMS ; BLOCK-COPOLYMER ; POLYMERIC VESICLES ; TRIGGERED RELEASE ; PHOTO ; HYDROGELS ; MICELLES ; PROTEIN ; CELLS ; MICROPARTICLES
英文摘要:

Light-responsive drug delivery systems are particularly appealing that are capable of releasing active molecules at the appropriate site and rate. We synthesized a series of photodegradable polymers that can form nanoparticles for drug encapsulation. These particles in aqueous solutions are stable in buffers with different pHs or at evaluated temperatures, while light can trigger the crash of particles and the release of encapsulated substances. The release efficiency can reach up to 90% based on Nile red fluorescence intensity upon 15 min light irradiation. Nanoparticle uptake by phagocytic cells and light-triggered release in cells were observed by fluorescence emission of the hydrolyzed fluorescein diacetate upon photoinduced degradation of these nanoparticles. No significant toxicity of these nanoparticles was found at the concentrations up to 1000 mu g/mL before or after light irradiation. Further encapsulation and triggered release of a bioactive model drug (Tagalsin G) was evaluated for RAW 264.7 cells. Tagalsin G encapsulated in nanoparticles did not show cytotoxity to cells, while light triggered the release of Tagalsin G increasing cell death dramatically from 9% to 67%. Our model studies show a new promising strategy to trigger drug release in cells.

语种: 英语
所属项目编号: 21072015 ; NCET-10-0203 ; BMU20110263
项目资助者: National Science Foundation of China ; Program for New Century Excellent Talents in University ; Innovation Team of Ministry of Education
WOS记录号: WOS:000305661400027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52638
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Lv, Cong,Wang, Zhen,Wang, Peng,et al. Photodegradable Polyurethane Self-Assembled Nanoparticles for Photocontrollable Release[J]. LANGMUIR,2012,28(25):9387-9394.
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