IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Effects of total glucosides of paeony for delaying onset of Sjogren′s syndrome: An animal study
Li, Chun Lei1; He, Jing2; Li, Zhan Guo2; Zheng, Li Wu3; Hua, Hong1
关键词Sjogren&Prime s Syndrome Sialoadenitis Total Glucosides Of Paeony Animal Model
刊名JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
2013-10-01
DOI10.1016/j.jcms.2012.11.042
41期:7页:610-615
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
关键词[WOS]REGULATORY T-CELLS ; SALIVARY-GLAND ; NOD MICE ; HYDROXYCHLOROQUINE TREATMENT ; AUTOIMMUNE-DISEASE ; MECHANISM ; MOUSE ; INTERLEUKIN-17 ; EXPRESSION ; ARTHRITIS
英文摘要

Objective: To investigate the effectiveness of total glucosides of paeony (TGP) on Sjogren′s syndrome (SS) using non-obese diabetic (NOD) mice model.

Study design: Twenty-seven 8-week-old female NOD mice were assigned into TGP group, hydroxychloroquine (HCQ) group and normal saline (NS) group, receiving corresponding drugs respectively and sacrificed at 24-week-old. Saliva flow rate (SFR), ration of regulatory T cells, level of anti-SSA/SSB, histological changes in submandibular glands (SMG) and microarray analysis were assessed. The data were analyzed using SPSS.

Results: Compared to NS group, in TGP group, SFR, SMG index and the ration of regulatory T cells were significantly higher, while anti-SSA/SSB and lymphocytic foci were significantly lower. HCQ group demonstrated similar results except SMG index. Altered gene expression was found in 10.71% of TGP and 13.09% of HCQ of the profile.

Conclusion: TGP demonstrated a similar effectiveness as HCQ in delaying the onset of SS-like disease in NOD mice. (C) 2012 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

语种英语
所属项目编号30672320 ; 31070788
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000325835000013
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52639
Collection北京大学第二临床医学院
作者单位1.Peking Univ, Dept Oral Med & Tradit Chinese Med, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
2.Peking Univ, Dept Rheumatol & Immunol, Peoples Hosp, Beijing 100081, Peoples R China
3.Univ Hong Kong, Fac Dent, Discipline Oral Diag & Polyclin, Hong Kong, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Li, Chun Lei,He, Jing,Li, Zhan Guo,et al. Effects of total glucosides of paeony for delaying onset of Sjogren′s syndrome: An animal study[J]. JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY,2013,41(7):610-615.
APA Li, Chun Lei,He, Jing,Li, Zhan Guo,Zheng, Li Wu,&Hua, Hong.(2013).Effects of total glucosides of paeony for delaying onset of Sjogren′s syndrome: An animal study.JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY,41(7),610-615.
MLA Li, Chun Lei,et al."Effects of total glucosides of paeony for delaying onset of Sjogren′s syndrome: An animal study".JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY 41.7(2013):610-615.
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