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学科主题: 基础医学
题名:
CTLA4-IgG ameliorates homocysteine-accelerated atherosclerosis by inhibiting T-cell overactivation in apoE(/) mice
作者: Ma, Kongyang1,2; Lv, Silin1,2; Liu, Bo1,2; Liu, Ziyi1,2; Luo, Yuhong1,2; Kong, Wei1,2; Xu, Qingbo3; Feng, Juan1,2; Wang, Xian1,2
关键词: Homocysteine ; Atherosclerosis ; CTLA4-IgG ; T cell ; Overactivation
刊名: CARDIOVASCULAR RESEARCH
发表日期: 2013-02-01
DOI: 10.1093/cvr/cvs330
卷: 97, 期:2, 页:349-359
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: CD28-DEFICIENT MICE ; SURFACE EXPRESSION ; 2-SIGNAL MODEL ; DEFICIENT MICE ; CD28 ; CTLA-4 ; ACTIVATION ; MECHANISMS ; PATHWAY ; COSTIMULATION
英文摘要:

Cytotoxic T lymphocyte antigen 4 (CTLA4) exerts inhibitory effects on T-cell activation by competition with CD28. In this study, we investigated the effect of CTLA4-IgG on homocysteine (Hcy)-induced T-cell activation and potential signal pathways involved in atherosclerotic formation.

The CD28 signal was significantly amplified by Hcy treatment in splenic T cells and hyperhomocysteinaemia (HHcy)-accelerated plaques in apolipoprotein E-deficient (apoE(/)) mice. As a major competitor of CD28, CTLA4-IgG (abatacept) pretreatment, 100 g/week, in apoE(/) mice could reverse 2- and 4-week HHcy-accelerated atherosclerosis. Furthermore, the membrane level of CTLA4 was decreased and the endocytosis level was increased by HHcy. Endocytosed CTLA4 molecules by Hcy were in large vesicles, colocalized with lysosomes and endosomes. Hcy-increased CTLA4 endocytosis and secretion of inflammatory cytokines in T cells were blocked by CTLA4-IgG and the PI3K inhibitor LY294002. Blocking the CD28 signal pathway in T cells significantly decreased Hcy-promoted macrophage migration.

These results illustrate a novel mechanism of CD28-dependent T-cell costimulation involved in HHcy-accelerated atherosclerosis, which extends the pharmacological application of CTLA4-IgG for atherosclerosis.

语种: 英语
所属项目编号: 2011CB503904 ; 2010CB912504 ; 81121061 ; 81000115 ; 20100001120049
项目资助者: National Basic Research Program of the P.R. China ; National Natural Science Foundation of the P.R. China ; Research Fund for the Doctoral Program of Higher Education
WOS记录号: WOS:000313827400019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52642
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
3.Kings Coll London, BHF Ctr, Div Cardiovasc, London SE5 9NU, England

Recommended Citation:
Ma, Kongyang,Lv, Silin,Liu, Bo,et al. CTLA4-IgG ameliorates homocysteine-accelerated atherosclerosis by inhibiting T-cell overactivation in apoE(/) mice[J]. CARDIOVASCULAR RESEARCH,2013,97(2):349-359.
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