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学科主题: 药学
题名:
Synthesis, characterization and biocompatibility of poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)-poly(2-ethyl-2-oxazoline) hydrogels
作者: Wang, X.1; Li, X.1; Li, Y.2; Zhou, Y.1; Fan, C.1; Li, W.1; Ma, S.1; Fan, Y.1; Huang, Y.3; Li, N.1; Liu, Y.1
关键词: Thermosensitive hydrogel ; Human skin fibroblast cells ; Biocompatibility ; Poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)-poly(2-ethyl-2-oxazoline) ; Scaffold
刊名: ACTA BIOMATERIALIA
发表日期: 2011-12-01
DOI: 10.1016/j.actbio.2011.07.011
卷: 7, 期:12, 页:4149-4159
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: PEG TRIBLOCK COPOLYMERS ; DRUG-DELIVERY SYSTEM ; THERMOSENSITIVE HYDROGEL ; THERMOREVERSIBLE GELATION ; PCL-PEG ; POLY(ETHYLENE GLYCOL) ; CONTROLLED-RELEASE ; AQUEOUS-SOLUTIONS ; BLOCK-COPOLYMERS ; CELLS
英文摘要:

A novel thermoreversible hydrogel based on poly(2-ethyl-2-oxazoline)-derived amphiphilic triblock copolymer, poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)-poly(2-ethyl-2-oxazoline) (PEOz-PLA-PEOz), was developed. The synthesis of PEOz-PLA-PEOz was carried out by coupling monohydroxylated PEOz-PLA diblocks with adipoyl chloride as coupling agent and dimethylamino pyridine as catalyst. The tube inverting and rheological tests showed that triblock copolymers had sol-gel-sol transition behavior with increasing temperature, and the gelation was found to be thermoreversible. The critical gelation concentration, the sol-gel transition temperature at a given concentration depended on the EOz/LA ratio and the molecular weight of PEOz. Scanning electron microscopy observation revealed that the resultant bulky gel exhibited an interconnected porous three-dimensional (3D) microstructure after freeze-drying. In addition, the hydrogels showed good cytocompatibility in vitro. MIT assays revealed that the human skin fibroblast cells encapsulated within the hydrogels were viable and proliferated inside the 3D scaffold. This newly described thermoreversible hydrogel demonstrated attractive properties to serve as cell matrix for a variety of tissue engineering applications or pharmaceutical delivery vehicles. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2009zx09310 ; 2009CB930300
项目资助者: National Development of Significant New Drugs (New Preparation and New Technology) ; National Basic Research Program of China (973 program)
WOS记录号: WOS:000297436500007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52653
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Cent Lab, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100191, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Pharmaceut Teaching Expt Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Wang, X.,Li, X.,Li, Y.,et al. Synthesis, characterization and biocompatibility of poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)-poly(2-ethyl-2-oxazoline) hydrogels[J]. ACTA BIOMATERIALIA,2011,7(12):4149-4159.
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