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Synthesis, characterization and biocompatibility of poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)-poly(2-ethyl-2-oxazoline) hydrogels
Wang, X.1; Li, X.1; Li, Y.2; Zhou, Y.1; Fan, C.1; Li, W.1; Ma, S.1; Fan, Y.1; Huang, Y.3; Li, N.1; Liu, Y.1
关键词Thermosensitive Hydrogel Human Skin Fibroblast Cells Biocompatibility Scaffold Poly(2-ethyl-2-oxazoline)-Poly(d L-lactide)-poly(2-ethyl-2-oxazoline)
刊名ACTA BIOMATERIALIA
2011-12-01
DOI10.1016/j.actbio.2011.07.011
7期:12页:4149-4159
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]PEG TRIBLOCK COPOLYMERS ; DRUG-DELIVERY SYSTEM ; THERMOSENSITIVE HYDROGEL ; THERMOREVERSIBLE GELATION ; PCL-PEG ; POLY(ETHYLENE GLYCOL) ; CONTROLLED-RELEASE ; AQUEOUS-SOLUTIONS ; BLOCK-COPOLYMERS ; CELLS
英文摘要

A novel thermoreversible hydrogel based on poly(2-ethyl-2-oxazoline)-derived amphiphilic triblock copolymer, poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)-poly(2-ethyl-2-oxazoline) (PEOz-PLA-PEOz), was developed. The synthesis of PEOz-PLA-PEOz was carried out by coupling monohydroxylated PEOz-PLA diblocks with adipoyl chloride as coupling agent and dimethylamino pyridine as catalyst. The tube inverting and rheological tests showed that triblock copolymers had sol-gel-sol transition behavior with increasing temperature, and the gelation was found to be thermoreversible. The critical gelation concentration, the sol-gel transition temperature at a given concentration depended on the EOz/LA ratio and the molecular weight of PEOz. Scanning electron microscopy observation revealed that the resultant bulky gel exhibited an interconnected porous three-dimensional (3D) microstructure after freeze-drying. In addition, the hydrogels showed good cytocompatibility in vitro. MIT assays revealed that the human skin fibroblast cells encapsulated within the hydrogels were viable and proliferated inside the 3D scaffold. This newly described thermoreversible hydrogel demonstrated attractive properties to serve as cell matrix for a variety of tissue engineering applications or pharmaceutical delivery vehicles. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000297436500007
项目编号2009zx09310 ; 2009CB930300
资助机构National Development of Significant New Drugs (New Preparation and New Technology) ; National Basic Research Program of China (973 program)
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52653
专题北京大学药学院_药剂学系
作者单位1.Peking Univ, Hosp 3, Cent Lab, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100191, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Pharmaceut Teaching Expt Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, X.,Li, X.,Li, Y.,et al. Synthesis, characterization and biocompatibility of poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)-poly(2-ethyl-2-oxazoline) hydrogels[J]. ACTA BIOMATERIALIA,2011,7(12):4149-4159.
APA Wang, X..,Li, X..,Li, Y..,Zhou, Y..,Fan, C..,...&Liu, Y..(2011).Synthesis, characterization and biocompatibility of poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)-poly(2-ethyl-2-oxazoline) hydrogels.ACTA BIOMATERIALIA,7(12),4149-4159.
MLA Wang, X.,et al."Synthesis, characterization and biocompatibility of poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)-poly(2-ethyl-2-oxazoline) hydrogels".ACTA BIOMATERIALIA 7.12(2011):4149-4159.
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