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学科主题: 基础医学
题名:
Synergistic effect of cholecystokinin octapeptide and angiotensin II in reversal of morphine induced analgesia in rats
作者: Han, NL1; Luo, F1; Bian, ZP1; Han, JS1
关键词: morphine induced analgesia ; cholecystokinin octapeptide ; angiotensin II ; intracerebroventricular injection ; synergistic effect
刊名: PAIN
发表日期: 2000-04-01
卷: 85, 期:3, 页:465-469
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Anesthesiology ; Clinical Neurology ; Neurosciences
研究领域[WOS]: Anesthesiology ; Neurosciences & Neurology
关键词[WOS]: NUCLEUS-ACCUMBENS ; OPIOID AGONISTS ; CALCIUM ; MU ; COMBINATIONS ; MOBILIZATION ; HABENULA ; NEURONS
英文摘要:

The aim of this paper is to study the synergistic anti-analgesic effect of angiotensin II (Ang II) plus cholecystokinin octapeptide (CCK-8). Our previous studies have shown that both CCK-8 and Ang LT are potent anti-opioid substances. Intracerebroventricular (i.c.v.) injection of CCK-8 or Ang II dose-dependently antagonizes morphine-induced analgesia (MIA). In the present study, we observed the combined effect of CCK-g and Ang II in antagonizing MIA. CCK-8 and Ang II were injected intracerebroventricularly to rats in various proportions and doses. The results were analyzed with isobolographic analysis. Combined injection of CCK-8 and Ang II in a ratio of 1 ng: 2.5 mu g or 1 ng: 5 mu g produced significantly greater effect in antagonizing MIA. The ED50 Of the two ratios are only 18.5% and 27.5%, respectively, of the theoretical dose of simple addition. We conclude that CCK-8 and Ang II used in such dose ratios may antagonize MIA synergistically. (C) 2000 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000086745500016
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52654
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Beijing Med Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Yian Bei Nursing Sch, Dept Physiol, Datong, Shanxi, Peoples R China

Recommended Citation:
Han, NL,Luo, F,Bian, ZP,et al. Synergistic effect of cholecystokinin octapeptide and angiotensin II in reversal of morphine induced analgesia in rats[J]. PAIN,2000,85(3):465-469.
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