北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 神经生物学系  > 期刊论文
学科主题: 基础医学
题名:
Synergistic effect of cholecystokinin octapeptide and angiotensin II in reversal of morphine induced analgesia in rats
作者: Han, NL1; Luo, F1; Bian, ZP1; Han, JS1
关键词: morphine induced analgesia ; cholecystokinin octapeptide ; angiotensin II ; intracerebroventricular injection ; synergistic effect
刊名: PAIN
发表日期: 2000-04-01
卷: 85, 期:3, 页:465-469
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Anesthesiology ; Clinical Neurology ; Neurosciences
研究领域[WOS]: Anesthesiology ; Neurosciences & Neurology
关键词[WOS]: NUCLEUS-ACCUMBENS ; OPIOID AGONISTS ; CALCIUM ; MU ; COMBINATIONS ; MOBILIZATION ; HABENULA ; NEURONS
英文摘要:

The aim of this paper is to study the synergistic anti-analgesic effect of angiotensin II (Ang II) plus cholecystokinin octapeptide (CCK-8). Our previous studies have shown that both CCK-8 and Ang LT are potent anti-opioid substances. Intracerebroventricular (i.c.v.) injection of CCK-8 or Ang II dose-dependently antagonizes morphine-induced analgesia (MIA). In the present study, we observed the combined effect of CCK-g and Ang II in antagonizing MIA. CCK-8 and Ang II were injected intracerebroventricularly to rats in various proportions and doses. The results were analyzed with isobolographic analysis. Combined injection of CCK-8 and Ang II in a ratio of 1 ng: 2.5 mu g or 1 ng: 5 mu g produced significantly greater effect in antagonizing MIA. The ED50 Of the two ratios are only 18.5% and 27.5%, respectively, of the theoretical dose of simple addition. We conclude that CCK-8 and Ang II used in such dose ratios may antagonize MIA synergistically. (C) 2000 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000086745500016
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52654
Appears in Collections:基础医学院_神经生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Synergistic effect of cholecystokinin octapeptide and angiotensin II in reversal of morphine induced analgesia in rats.pdf(135KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Beijing Med Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Yian Bei Nursing Sch, Dept Physiol, Datong, Shanxi, Peoples R China

Recommended Citation:
Han, NL,Luo, F,Bian, ZP,et al. Synergistic effect of cholecystokinin octapeptide and angiotensin II in reversal of morphine induced analgesia in rats[J]. PAIN,2000,85(3):465-469.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Han, NL]'s Articles
[Luo, F]'s Articles
[Bian, ZP]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Han, NL]‘s Articles
[Luo, F]‘s Articles
[Bian, ZP]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace