IR@PKUHSC  > 北京大学第三临床医学院  > 消化科
学科主题临床医学
Multicenter case-control study of the risk factors for ulcerative colitis in China
Wang, Yu-Fang1; Qin Ou-yang1; Xia, Bing2; Liu, Li-Na3; Gu, Fang4; Zhou, Kai-Fang5; Mei, Qiao6; Shi, Rui-Hua7; Ran, Zhi-Hua8; Wang, Xiao-Di9; Hu, Pin-Jin10; Wu, Kai-Chun11,12; Liu, Xin-Guang13; Miao, Ying-Lei14; Han, Ying15; Wu, Xiao-Ping16; He, Guo-Bing17; Zhong, Jie18; Liu, Guan-Jian19
关键词Ulcerative Colitis Risk Factors Case-control Study
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2013-03-21
DOI10.3748/wjg.v19.i11.1827
19期:11页:1827-1833
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]INFLAMMATORY-BOWEL-DISEASE ; CROHNS-DISEASE ; RETROSPECTIVE ANALYSIS ; ANTIBIOTIC USE ; EPIDEMIOLOGY ; LIFE ; GASTROENTERITIS ; CONSUMPTION ; POPULATION ; CAPSAICIN
英文摘要

AIM: To evaluate potential risk factors in the development of ulcerative colitis (UC) in China.

METHODS: A total of 1308 patients with UC and 1308 age-matched and sex-matched controls were prospectively studied in China. The UC cases were collected from 17 hospitals in China from April 2007 to April 2010. Uniform questionnaires were designed to investigate risk factors including smoking, appendectomy, stress, socio-economic conditions, nonsteroidal anti-inflammatory drugs (NSAIDs), oral contraceptives, diet, breastfeeding, infections and family sanitary conditions. Group comparisons by each factor were done using simple logistic regression analysis. Conditional logistic regression was used for multivariate analysis.

RESULTS: By univariate analysis, the variables predictive of UC included feeling stress, light and heavy alcoholic drinking, spicy food, sugar consumption and infectious diarrhea, while heavy tea intake and tap water consumption were protective against UC. On multivariate analysis, the protective factor for UC was tap water consumption [odds ratios (OR) = 0.424, 95% CI: 0.302-0.594, P < 0.001]; while the potential risk factors for UC were heavy sugar consumption (OR = 1.632, 95% CI: 1.156-2.305, P < 0.001), spicy food (light intake: OR = 3.329, 95% CI: 2.282-4.857, P < 0.001; heavy intake: OR = 3.979, 95% CI: 2.700-5.863, P < 0.001), and often feeling stress (OR = 1.981, 95% CI: 1.447-2.711, P < 0.001). Other factors, such as smoking habit, appendectomy, breastfeeding, a history of measles, rural or urban residence, education, oral contraceptives, and NSAID use have not been found to have a significant association with the development of UC in the present study.

CONCLUSION: Our study showed tap water consumption was a protective factor for UC, while spicy food, heavy sugar consumption and often feeling stress were risk factors for UC in this Chinese population. (C) 2013 Baishideng. All rights reserved.

语种英语
WOS记录号WOS:000316551200017
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52656
专题北京大学第三临床医学院_消化科
作者单位1.Sichuan Univ, Dept Gastroenterol, West China Hosp, Chengdu 610041, Sichuan Provinc, Peoples R China
2.Wuhan Univ, Sch Med, Zhongnan Hosp, Dept Gastroenterol, Wuhan 430071, Hubei Province, Peoples R China
3.Dalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian 116021, Liaoning Provin, Peoples R China
4.Beijing Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
5.Huazhong Sci & Technol Univ, Tongji Med Coll, Union Hosp, Dept Gastroenterol, Wuhan 430074, Hubei Province, Peoples R China
6.Anhui Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Hefei 230022, Anhui, Peoples R China
7.Nanjing Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Nanjing 210029, Jiangsu, Peoples R China
8.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Gastroenterol, Shanghai 200127, Peoples R China
9.Beijing Sinojapan Friendship Hosp, Dept Gastroenterol, Beijing 10029, Peoples R China
10.Zhongshan Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Guangzhou 528000, Guangdong, Peoples R China
11.Fourth Mil Med Univ, State Key Lab Canc Biol, Xian 710032, Shaanxi Provinc, Peoples R China
12.Fourth Mil Med Univ, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Provinc, Peoples R China
13.Peking Univ, Affiliated Hosp 1, Dept Gastroenterol, Beijing 100034, Peoples R China
14.Kunming Med Coll, Affiliated Hosp 1, Dept Gastroenterol, Kunming 650032, Yunnan Province, Peoples R China
15.Mil Gen Hosp Beijing PLA, Dept Gastroenterol, Beijing 10026, Peoples R China
16.Zhongnan Univ, Affiliated Hosp 2, Xiangya Hosp, Dept Gastroenterol, Changsha 410008, Hunan, Peoples R China
17.North Sichuan Med Coll, Affiliated Hosp, Dept Gastroenterol, Nanyun 637000, Sichuan Provinc, Peoples R China
18.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Gastroenterol, Shanghai 200025, Peoples R China
19.Sichuan Univ, Dept Epidemiol, West China Hosp, Chengdu 610041, Sichuan Provinc, Peoples R China
推荐引用方式
GB/T 7714
Wang, Yu-Fang,Qin Ou-yang,Xia, Bing,et al. Multicenter case-control study of the risk factors for ulcerative colitis in China[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2013,19(11):1827-1833.
APA Wang, Yu-Fang.,Qin Ou-yang.,Xia, Bing.,Liu, Li-Na.,Gu, Fang.,...&Liu, Guan-Jian.(2013).Multicenter case-control study of the risk factors for ulcerative colitis in China.WORLD JOURNAL OF GASTROENTEROLOGY,19(11),1827-1833.
MLA Wang, Yu-Fang,et al."Multicenter case-control study of the risk factors for ulcerative colitis in China".WORLD JOURNAL OF GASTROENTEROLOGY 19.11(2013):1827-1833.
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