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学科主题: 临床医学
题名:
Multicenter case-control study of the risk factors for ulcerative colitis in China
作者: Wang, Yu-Fang1; Qin Ou-yang1; Xia, Bing2; Liu, Li-Na3; Gu, Fang4; Zhou, Kai-Fang5; Mei, Qiao6; Shi, Rui-Hua7; Ran, Zhi-Hua8; Wang, Xiao-Di9; Hu, Pin-Jin10; Wu, Kai-Chun11,12; Liu, Xin-Guang13; Miao, Ying-Lei14; Han, Ying15; Wu, Xiao-Ping16; He, Guo-Bing17; Zhong, Jie18; Liu, Guan-Jian19
关键词: Ulcerative colitis ; Risk factors ; Case-control study
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2013-03-21
DOI: 10.3748/wjg.v19.i11.1827
卷: 19, 期:11, 页:1827-1833
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: INFLAMMATORY-BOWEL-DISEASE ; CROHNS-DISEASE ; RETROSPECTIVE ANALYSIS ; ANTIBIOTIC USE ; EPIDEMIOLOGY ; LIFE ; GASTROENTERITIS ; CONSUMPTION ; POPULATION ; CAPSAICIN
英文摘要:

AIM: To evaluate potential risk factors in the development of ulcerative colitis (UC) in China.

METHODS: A total of 1308 patients with UC and 1308 age-matched and sex-matched controls were prospectively studied in China. The UC cases were collected from 17 hospitals in China from April 2007 to April 2010. Uniform questionnaires were designed to investigate risk factors including smoking, appendectomy, stress, socio-economic conditions, nonsteroidal anti-inflammatory drugs (NSAIDs), oral contraceptives, diet, breastfeeding, infections and family sanitary conditions. Group comparisons by each factor were done using simple logistic regression analysis. Conditional logistic regression was used for multivariate analysis.

RESULTS: By univariate analysis, the variables predictive of UC included feeling stress, light and heavy alcoholic drinking, spicy food, sugar consumption and infectious diarrhea, while heavy tea intake and tap water consumption were protective against UC. On multivariate analysis, the protective factor for UC was tap water consumption [odds ratios (OR) = 0.424, 95% CI: 0.302-0.594, P < 0.001]; while the potential risk factors for UC were heavy sugar consumption (OR = 1.632, 95% CI: 1.156-2.305, P < 0.001), spicy food (light intake: OR = 3.329, 95% CI: 2.282-4.857, P < 0.001; heavy intake: OR = 3.979, 95% CI: 2.700-5.863, P < 0.001), and often feeling stress (OR = 1.981, 95% CI: 1.447-2.711, P < 0.001). Other factors, such as smoking habit, appendectomy, breastfeeding, a history of measles, rural or urban residence, education, oral contraceptives, and NSAID use have not been found to have a significant association with the development of UC in the present study.

CONCLUSION: Our study showed tap water consumption was a protective factor for UC, while spicy food, heavy sugar consumption and often feeling stress were risk factors for UC in this Chinese population. (C) 2013 Baishideng. All rights reserved.

语种: 英语
所属项目编号: 07040490057
项目资助者: Chinese Medical Association Research Special Funds
WOS记录号: WOS:000316551200017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52656
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

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作者单位: 1.Sichuan Univ, Dept Gastroenterol, West China Hosp, Chengdu 610041, Sichuan Provinc, Peoples R China
2.Wuhan Univ, Sch Med, Zhongnan Hosp, Dept Gastroenterol, Wuhan 430071, Hubei Province, Peoples R China
3.Dalian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Dalian 116021, Liaoning Provin, Peoples R China
4.Beijing Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
5.Huazhong Sci & Technol Univ, Tongji Med Coll, Union Hosp, Dept Gastroenterol, Wuhan 430074, Hubei Province, Peoples R China
6.Anhui Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Hefei 230022, Anhui, Peoples R China
7.Nanjing Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Nanjing 210029, Jiangsu, Peoples R China
8.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Gastroenterol, Shanghai 200127, Peoples R China
9.Beijing Sinojapan Friendship Hosp, Dept Gastroenterol, Beijing 10029, Peoples R China
10.Zhongshan Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Guangzhou 528000, Guangdong, Peoples R China
11.Fourth Mil Med Univ, State Key Lab Canc Biol, Xian 710032, Shaanxi Provinc, Peoples R China
12.Fourth Mil Med Univ, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Provinc, Peoples R China
13.Peking Univ, Affiliated Hosp 1, Dept Gastroenterol, Beijing 100034, Peoples R China
14.Kunming Med Coll, Affiliated Hosp 1, Dept Gastroenterol, Kunming 650032, Yunnan Province, Peoples R China
15.Mil Gen Hosp Beijing PLA, Dept Gastroenterol, Beijing 10026, Peoples R China
16.Zhongnan Univ, Affiliated Hosp 2, Xiangya Hosp, Dept Gastroenterol, Changsha 410008, Hunan, Peoples R China
17.North Sichuan Med Coll, Affiliated Hosp, Dept Gastroenterol, Nanyun 637000, Sichuan Provinc, Peoples R China
18.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Gastroenterol, Shanghai 200025, Peoples R China
19.Sichuan Univ, Dept Epidemiol, West China Hosp, Chengdu 610041, Sichuan Provinc, Peoples R China

Recommended Citation:
Wang, Yu-Fang,Qin Ou-yang,Xia, Bing,et al. Multicenter case-control study of the risk factors for ulcerative colitis in China[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2013,19(11):1827-1833.
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