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学科主题: 药学
题名:
Pharmacokinetics and pharmacodynamics of sterylglucoside-modified liposomes for levonorgestrel delivery via nasal route
作者: Ding, Wu-Xiao1; Qi, Xian-Rong1; Fu, Qiang1; Piao, Hui-Shan1
关键词: contraception ; levonorgestrel ; nasal ; pharmacokinetics ; sterylglucoside
刊名: DRUG DELIVERY
发表日期: 2007-02-01
DOI: 10.1080/10717540600740102
卷: 14, 期:2, 页:101-104
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: DRUG-DELIVERY ; ABSORPTION ; CHITOSAN ; RATS
英文摘要:

For emergency contraceptive, the rapid delivery of levonorgestrel (LNG) to plasma is desirable, furthermore, a sustained delivery of LNG along with rapid absorption will be necessary. The pharmacokinetics and pharmacodynamics of LNG entrapped in different kinds of liposome formulations via nasal administration in rats were evaluated and compared with LNG suspension via the oral route. The relative bioavailabilities of these liposome formulations via nasal administration were 100% or higher than 100%. The C-max, and T-max values of sterylglucoside (SG) and chitosan-contained formulations by nasal administration were 416.84 ng/mL and 1.02 hr, 227.97 ng/mL and 2.02 hr, respectively, compared with that of 334.94 ng/mL and 1.89 hr of oral suspension. Fully 100% contraception was observed for all the formulations. SG could promote the absorption of LNG via the nasal route and may provide a rapid onset of action of LNG for emergency contraception. Chitosan could retain LNG in the nasal cavity for long contact time to sustain delivery of LNG. The rapid onset and sustained delivery of LNG can be achieved via the nasal route using liposomes as the vehicle.

语种: 英语
WOS记录号: WOS:000243882900006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52657
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Yanbian Univ, Sch Pharmaceut Sci, Yanji, Jilin, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China

Recommended Citation:
Ding, Wu-Xiao,Qi, Xian-Rong,Fu, Qiang,et al. Pharmacokinetics and pharmacodynamics of sterylglucoside-modified liposomes for levonorgestrel delivery via nasal route[J]. DRUG DELIVERY,2007,14(2):101-104.
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