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学科主题: 临床医学
题名:
Changes of atrial natriuretic peptide and antidiuretic hormone in children with postural tachycardia syndrome and orthostatic hypertension: a case control study
作者: Zhao Juan1; Yang Jinyan1; Du Shuxu2; Tang Chaoshu3,4; Du Junbao1; Jin Hongfang1
关键词: postural tachycardia syndrome ; atrial natriuretic peptide ; antidiuretic hormone ; orthostatic hypertension
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2014-05-20
DOI: 10.3760/cma.j.issn.0366-6999.20140336
卷: 127, 期:10, 页:1853-1857
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: BAROREFLEX CONTROL ; INTOLERANCE ; DIAGNOSIS ; PRESSURE ; FAILURE ; SYNCOPE
英文摘要:

Background The abnormal blood volume regulation is one of the most important pathogenesis in postural tachycardia syndrome in children. This study was designed to investigate the plasma atrial natriuretic peptide and antidiuretic hormone levels in postural tachycardia syndrome children, and their associations with the changes in heart rate and blood pressure in head-up test.

Methods Twenty-one postural tachycardia syndrome patients ((12 2) years) and 26 healthy children ((12 1) years) were included. According to blood pressure changes in head-up test, the postural tachycardia syndrome patients were divided into two subgroups: postural tachycardia syndrome with orthostatic hypertension and postural tachycardia syndrome without orthostatic hypertension. The plasma atrial natriuretic peptide and antidiuretic hormone levels were measured using enzyme-linked immunosorbent assay.

Results The plasma atrial natriuretic peptide level in postural tachycardia syndrome patients was higher than the control (P=0.004), whereas the difference in plasma antidiuretic hormone level between postural tachycardia syndrome and controls was not significant (P=0.222). The plasma antidiuretic hormone level of patients suffering from postural tachycardia syndrome with orthostatic hypertension was much higher than that of children having postural tachycardia syndrome without orthostatic hypertension (P <0.05). In postural tachycardia syndrome patients, the upright max heart rate was positively correlated with the plasma atrial natriuretic peptide level (r=0.490, P<0.05) and the upright systolic blood pressure was positively correlated with the plasma antidiuretic hormone levels (r=0.472, P <0.05).

Conclusions There was a disturbance of plasma atrial natriuretic peptide and antidiuretic hormone in postural tachycardia syndrome children.

语种: 英语
所属项目编号: 2012BAI03B03 ; 2012CB517806 ; 2011CB503904 ; 81121061
项目资助者: National Twelfth Five-Year Plan for Science &amp ; Technology Support ; Major Basic Research Project of China ; National Natural Science Foundation of China
WOS记录号: WOS:000336477100011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52661
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Capital Med Univ, Dept Pediat, Shijitan Hosp, Beijing 100038, Peoples R China
3.Peking Univ, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Beijing 100191, Peoples R China
4.Minist Educ, Key Lab Mol Cardiol, Beijing 100191, Peoples R China

Recommended Citation:
Zhao Juan,Yang Jinyan,Du Shuxu,et al. Changes of atrial natriuretic peptide and antidiuretic hormone in children with postural tachycardia syndrome and orthostatic hypertension: a case control study[J]. CHINESE MEDICAL JOURNAL,2014,127(10):1853-1857.
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