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学科主题: 临床医学
题名:
The J wave and fragmented QRS complexes in inferior leads associated with sudden cardiac death in patients with chronic heart failure
作者: Pei, Juanhui1,2,3; Li, Ning1,2,3; Gao, Yonghong4; Wang, Zengwu1,2,3; Li, Xian1,2,3; Zhang, Yinhui1,2,3; Chen, Jingzhou1,2,3; Zhang, Ping5; Cao, Kejiang6; Pu, Jielin1,2,3
关键词: J wave ; fQRS ; Sudden cardiac death ; Chronic heart failure ; TpTe
刊名: EUROPACE
发表日期: 2012-08-01
DOI: 10.1093/europace/eur437
卷: 14, 期:8, 页:1180-1187
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: LONG-QT-SYNDROME ; IDIOPATHIC DILATED CARDIOMYOPATHY ; ST SEGMENT ELEVATION ; T-WAVE ; EARLY REPOLARIZATION ; VENTRICULAR-FIBRILLATION ; TRANSMURAL DISPERSION ; BRUGADA-SYNDROME ; 12-LEAD ECG ; LQT2 FORMS
英文摘要:

To investigate the relationship between electrocardiogram (ECG) parameters [J wave, fragmented QRS (fQRS), QTc, the peak-to-end interval of T wave (TpTe)], and sudden cardiac death (SCD) in chronic heart failure (CHF).

The ECGs of 1570 CHF patients, 572 cases with dilated cardiomyopathy (DCM) and 998 cases with ischaemic cardiomyopathy (ICM) were analysed with the endpoint being an SCD or non-SCD (NSCD). During a median follow-up period of 36 months (0.4065 months), 438 (27.89) patients died, of which 158 (35.84) were SCD. Overall, the occurrence of J wave, fQRS, and long TpTe were greater in SCD patients than that of NSCD patients (all P 0.01). For DCM cases, more SCD patients had J waves observed in the inferior leads than that in the NSCD group (26.78 vs. 13.07, P0.001). However, ICM cases with SCD did have more fQRS in the inferior leads than that with NSCD (42.16 vs. 26.67, P 0.01). After adjusting for other risk factors, Cox regression analysis revealed that presence of J wave or fQRS in the inferior leads predicted a higher risk for SCD in DCM [hazard ratio (HR), 4.095; 95 confidence interval (CI), 2.1327.863] and ICM (HR, 2.714; 95 CI, 1.8094.072) patients. A left ventricular ejection fraction 30 also predicted SCD and NSCD in DCM and ICM patients. In contrast, the predictive value of QTc and TpTe for SCD was not significant.

Presence of J wave or fQRS in the inferior leads predicted higher risk of SCD in DCM and ICM patients and might serve as independent predictors for SCD in patients with CHF.

语种: 英语
所属项目编号: 2007CB512000 ; 2007CB512008
项目资助者: National Basic Research Program of China (973 program)
WOS记录号: WOS:000306925700021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52664
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
2.First Peoples Hosp Jiangsu Prov, Nanjing, Jiangsu, Peoples R China
3.Beijing Aerosp Hosp, Beijing, Peoples R China
4.Chinese Acad Med Sci, Fuwai Hosp, State Key Lab Translat Cardiovasc Med, Beijing 100037, Peoples R China
5.Chinese Acad Med Sci, Cardiovasc Inst, Beijing 100037, Peoples R China
6.Peking Union Med Coll, Beijing 100037, Peoples R China

Recommended Citation:
Pei, Juanhui,Li, Ning,Gao, Yonghong,et al. The J wave and fragmented QRS complexes in inferior leads associated with sudden cardiac death in patients with chronic heart failure[J]. EUROPACE,2012,14(8):1180-1187.
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