|A predictive value of quantitative HBsAg for serum HBV DNA level among HBeAg-positive pregnant women|
|Sun, Kui-Xia1,2; Li, Jie1,2; Zhu, Feng-Cai3; Liu, Jian-Xun4; Li, Rong-Cheng5; Zhai, Xiang-Jun3; Li, Yan-Ping5; Chang, Zhan-Jun4; Nie, Jing-Jing1,2; Zhuang, Hui1,2|
|关键词||Hepatitis B surface antigen Hepatitis B e antigen Hepatitis B virus DNA Quantitative HBsAg Pregnant women|
|WOS标题词||Science & Technology|
|类目[WOS]||Immunology ; Medicine, Research & Experimental|
|研究领域[WOS]||Immunology ; Research & Experimental Medicine|
|关键词[WOS]||HEPATITIS-B-VIRUS ; SURFACE-ANTIGEN ; PERINATAL TRANSMISSION ; VERTICAL TRANSMISSION ; NATURAL-HISTORY ; INFECTION ; MOTHERS ; INFANTS ; VACCINE ; CHINA|
Background: The high maternal HBV DNA level is the most important factor contributing to HBV perinatal transmission. This study is to explore whether HBsAg can be used as a surrogate marker of serum HBV DNA for HBsAg-positive pregnant women.
Methods: A total of 975 HBsAg-positive pregnant women and their infants were enrolled in this study. All infants received three doses of a yeast-derived recombinant Hepatitis B vaccine at 0, 1 and 6 months. They were also given Hepatitis B immunoglobulin (HBIG) at birth. HBsAg and HBeAg were determined using Abbott Architect assays while serum HBV DNA level was detected by the Abbott Real Time HBV DNA assay.
Results: Of the 975 subjects, 367 (37.6%) were HBeAg-positive and 608 (62.4%) were HBeAg-negative. Among the HBeAg-positive group, the samples with HBV DNA levels of >= 7.0 log IU/mL were 76.6% (281/367), and it was only 0.7% (4/608) for the HBeAg-negative group. HBV DNA level was positively correlated with HBsAg in HBeAg-positive group (r = 0.786, p < 0.001) but not in HBeAg-negative group (r = 0.022, p = 0.593). Among HBeAg-positive group, the area under the receiver-operator curve (ROC) of HBsAg titer for high HBV DNA level (>= 7.0 log IU/mL) was 0.961 (95% Cl. 0.940-0.983, p < 0.001). The optimum cut-off point HBsAg titer above 4.1 log IU/mL had a sensitivity of 85.1%, specificity of 96.5%, and accuracy of 87.5% to predict HBV DNA levels of >= 7.0 log IU/mL. Of 367 infants born to mothers with HBeAg-positive, perinatal transmission was detected in 24 infants (6.5%, 24/367). Their mothers all had serum HBV DNA levels of >= 7.0 log IU/mL, 23 (95.8%) had HBsAg titers of >= 4.1 log IU/mL and the other mother had HBsAg titer of 3.9 log IU/mL. Of 608 infants born to mothers with HBeAg-negative, only one (0.2%, 1/608) became HBsAg-positive at the age of 7 months, and the mother of the infant had serum HBV DNA level of 3.4 log IU/mL and HBsAg titer of 1.8 log IU/mL, respectively.
Conclusion: Serum HBsAg titer may be used as a surrogate marker of serum HBV DNA for HBeAg-positive pregnant women. (C) 2012 Elsevier Ltd. All rights reserved.
|项目编号||2008ZX10002-001 ; 2008ZX10002-012|
|资助机构||Major Science and Technology Special Project of China Eleventh Five-year Plan|
|作者单位||1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Microbiol, Beijing 100191, Peoples R China|
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Ctr Infect Dis, Beijing 100191, Peoples R China
3.Jiangsu Prov Ctr Dis Control & Prevent, Dept Infect Dis, Nanjing 210009, Peoples R China
4.Zhengzhou Municipal Ctr Dis Control & Prevent, Dept Major Projects, Zhengzhou 450053, Peoples R China
5.Guangxi Zhuang Autonomous Reg Ctr Dis Control & P, Nanning 530028, Peoples R China
|Sun, Kui-Xia,Li, Jie,Zhu, Feng-Cai,et al. A predictive value of quantitative HBsAg for serum HBV DNA level among HBeAg-positive pregnant women[J]. VACCINE,2012,30(36):5335-5340.|
|APA||Sun, Kui-Xia.,Li, Jie.,Zhu, Feng-Cai.,Liu, Jian-Xun.,Li, Rong-Cheng.,...&Zhuang, Hui.(2012).A predictive value of quantitative HBsAg for serum HBV DNA level among HBeAg-positive pregnant women.VACCINE,30(36),5335-5340.|
|MLA||Sun, Kui-Xia,et al."A predictive value of quantitative HBsAg for serum HBV DNA level among HBeAg-positive pregnant women".VACCINE 30.36(2012):5335-5340.|
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