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学科主题: 临床医学
题名:
The Renal Histopathology Spectrum of Elderly Patients with Kidney Diseases A Study of 430 Patients in a Single Chinese Center
作者: Zhu, Ping1,2,3,4; Zhou, Fu-de1,2,3; Zhao, Ming-hui1,2,3,5
刊名: MEDICINE
发表日期: 2014-12-01
DOI: 10.1097/MD.0000000000000226
卷: 93, 期:28
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: CLINICOPATHOLOGICAL ANALYSIS ; SPANISH REGISTRY ; ITALIAN REGISTRY ; BIOPSY ; GLOMERULONEPHRITIS ; OLDER ; EPIDEMIOLOGY
英文摘要:

The elderly population has significantly increased in China. However, data regarding renal histopathology in this population is lacking. The present study retrospectively analyzed renal disease spectrum of 430 elderly patients who had received renal biopsy at Peking University First Hospital between January 2003 and December 2012.

Among 6049 patients receiving renal biopsies during the same period, 430 (7.10%) were elderly (>= 65 years). The ratio of male (263 patients) to female (167 patients) was 1.57: 1, with an age of 70.29 +/- 3.99 (range 65-82) years at the time of biopsy. The most common indication for renal biopsy was nephrotic syndrome (59.53%), followed by acute kidney injury (AKI, 19.53%) and chronic glomerulonephritis (CGN, 16.05%). The most common renal histopathology in primary glomerular disease was idiopathic membranous nephropathy (iMN, 61.02%), followed by IgA nephropathy (18.22%), minimal change disease (MCD, 9.32%) and focal segmental glomerulosclerosis (6.78%). ANCA-associated vasculitis (AAV, 43.95%) was the leading secondary glomerular disease, followed by HBV-related glomerulonephritis (HBV-GN, 24.2%), and amyloidosis (14.01%). In patients with nephrotic syndrome, iMN (50%) was the leading cause, followed by HBV-GN (16.02%), MCD (7.81%), and amyloidosis (7.81%). In patients with iMN, 89.5% presented as nephrotic syndrome, 8.39% as CGN. In patients with AKI, the leading cause was AAV (48.12%), followed by acute interstitial nephritis (20.48%) and acute tubular necrosis (8.43%).

In conclusion, in elderly Chinese patients, the most common renal histopathology pattern was iMN in patients with nephrotic syndrome, and AAV in patients with AKI.

语种: 英语
所属项目编号: 2012CB517702 ; 81321064
项目资助者: Chinese 973 project ; Natural Science Fund of China
WOS记录号: WOS:000346762200012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52674
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
2.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Div Renal, Dept Med,Inst Nephrol, Beijing 100871, Peoples R China
4.Minist Educ China, Key Lab CKD Prevent & Treatment, Beijing, Peoples R China
5.China Three Gorges Univ, Coll Clin Med Sci 1, Yichang, Peoples R China

Recommended Citation:
Zhu, Ping,Zhou, Fu-de,Zhao, Ming-hui. The Renal Histopathology Spectrum of Elderly Patients with Kidney Diseases A Study of 430 Patients in a Single Chinese Center[J]. MEDICINE,2014,93(28).
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