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学科主题临床医学
The Renal Histopathology Spectrum of Elderly Patients with Kidney Diseases A Study of 430 Patients in a Single Chinese Center
Zhu, Ping1,2,3,4; Zhou, Fu-de1,2,3; Zhao, Ming-hui1,2,3,5
刊名MEDICINE
2014-12-01
DOI10.1097/MD.0000000000000226
93期:28
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]CLINICOPATHOLOGICAL ANALYSIS ; SPANISH REGISTRY ; ITALIAN REGISTRY ; BIOPSY ; GLOMERULONEPHRITIS ; OLDER ; EPIDEMIOLOGY
英文摘要

The elderly population has significantly increased in China. However, data regarding renal histopathology in this population is lacking. The present study retrospectively analyzed renal disease spectrum of 430 elderly patients who had received renal biopsy at Peking University First Hospital between January 2003 and December 2012.

Among 6049 patients receiving renal biopsies during the same period, 430 (7.10%) were elderly (>= 65 years). The ratio of male (263 patients) to female (167 patients) was 1.57: 1, with an age of 70.29 +/- 3.99 (range 65-82) years at the time of biopsy. The most common indication for renal biopsy was nephrotic syndrome (59.53%), followed by acute kidney injury (AKI, 19.53%) and chronic glomerulonephritis (CGN, 16.05%). The most common renal histopathology in primary glomerular disease was idiopathic membranous nephropathy (iMN, 61.02%), followed by IgA nephropathy (18.22%), minimal change disease (MCD, 9.32%) and focal segmental glomerulosclerosis (6.78%). ANCA-associated vasculitis (AAV, 43.95%) was the leading secondary glomerular disease, followed by HBV-related glomerulonephritis (HBV-GN, 24.2%), and amyloidosis (14.01%). In patients with nephrotic syndrome, iMN (50%) was the leading cause, followed by HBV-GN (16.02%), MCD (7.81%), and amyloidosis (7.81%). In patients with iMN, 89.5% presented as nephrotic syndrome, 8.39% as CGN. In patients with AKI, the leading cause was AAV (48.12%), followed by acute interstitial nephritis (20.48%) and acute tubular necrosis (8.43%).

In conclusion, in elderly Chinese patients, the most common renal histopathology pattern was iMN in patients with nephrotic syndrome, and AAV in patients with AKI.

语种英语
WOS记录号WOS:000346762200012
项目编号2012CB517702 ; 81321064
资助机构Chinese 973 project ; Natural Science Fund of China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52674
专题北京大学第一临床医学院_肾脏内科
作者单位1.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
2.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Div Renal, Dept Med,Inst Nephrol, Beijing 100871, Peoples R China
4.Minist Educ China, Key Lab CKD Prevent & Treatment, Beijing, Peoples R China
5.China Three Gorges Univ, Coll Clin Med Sci 1, Yichang, Peoples R China
推荐引用方式
GB/T 7714
Zhu, Ping,Zhou, Fu-de,Zhao, Ming-hui. The Renal Histopathology Spectrum of Elderly Patients with Kidney Diseases A Study of 430 Patients in a Single Chinese Center[J]. MEDICINE,2014,93(28).
APA Zhu, Ping,Zhou, Fu-de,&Zhao, Ming-hui.(2014).The Renal Histopathology Spectrum of Elderly Patients with Kidney Diseases A Study of 430 Patients in a Single Chinese Center.MEDICINE,93(28).
MLA Zhu, Ping,et al."The Renal Histopathology Spectrum of Elderly Patients with Kidney Diseases A Study of 430 Patients in a Single Chinese Center".MEDICINE 93.28(2014).
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