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学科主题: 临床医学
题名:
D2 dissection in laparoscopic and open gastrectomy for gastric cancer
作者: Cui, Ming1; Xing, Jia-Di1; Yang, Wei2; Ma, Yi-Yuan1; Yao, Zhen-Dan1; Zhang, Nan1; Su, Xiang-Qian1
关键词: Gastric cancer ; Laparoscopy ; Gastrectomy ; D2 dissection ; Lymph node
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2012-02-28
DOI: 10.3748/wjg.v18.i8.833
卷: 18, 期:8, 页:833-839
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: ASSISTED DISTAL GASTRECTOMY ; LYMPH-NODE DISSECTION ; RANDOMIZED SURGICAL TRIAL ; SUBTOTAL GASTRECTOMY ; CLINICAL-TRIAL ; INTERIM-REPORT ; COMPARING OPEN ; PHASE-II ; MORTALITY ; SURVIVAL
英文摘要:

AIM: To evaluate the radicalness and safety of laparoscopic D2 dissection for gastric cancer.

METHODS: Clinicopathological data from 209 patients with gastric cancer, who underwent radical gastrectomy with D2 dissection between January 2007 and February 2011, were analyzed retrospectively. Among these patients, 131 patients underwent laparoscopy-assisted gastrectomy (LAG) and 78 underwent open gastrectomy (OG). The parameters analyzed included operative time, blood loss, blood transfusion, morbidity, mortality, the number of harvested lymph nodes (HLNs), and pathological stage.

RESULTS: There were no significant differences in sex, age, types of radical resection [radical proximal gastrectomy (PG + D2), radical distal gastrectomy (DG + D2) and radical total gastrectomy (TG + D2)], and stages between the LAG and OG groups (P > 0.05). Among the two groups, 127 cases (96.9%) and 76 cases (97.4%) had 15 or more HLNs, respectively. The average number of HLNs was 26.1 +/- 11.4 in the LAG group and 24.2 +/- 9.3 in the OG group (P = 0.233). In the same type of radical resection, there were no significant differences in the number of HLNs between the two groups (PG + D2: 21.7 +/- 7.5 vs 22.4 +/- 9.3; DG + D2: 25.7 +/- 11.0 vs 22.3 +/- 7.9; TG + D2: 30.9 +/- 13.4 vs 29.3 +/- 10.4; P > 0.05 for all comparisons). Tumor free margins were obtained in all cases. Compared with OG group, the LAG group had significantly less blood loss, but a longer operation time (P < 0.001). The morbidity of the LAG group was 9.9%, which was not significantly different from the OG group (7.7%) (P = 0.587). The mortality was zero in both groups.

CONCLUSION: Laparoscopic D2 dissection is equivalent to OG in the number of HLNs, regardless of tumor location. Thus, this procedure can achieve the same radicalness as OG. (C) 2012 Baishideng. All rights reserved.

语种: 英语
项目资助者: The Capital Medical Development Research Fund
WOS记录号: WOS:000301082700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52680
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Minist Educ, Dept Minimally Invas Gastrointestinal Surg, Beijing 100142, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Ultrasound, Beijing 100142, Peoples R China

Recommended Citation:
Cui, Ming,Xing, Jia-Di,Yang, Wei,et al. D2 dissection in laparoscopic and open gastrectomy for gastric cancer[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2012,18(8):833-839.
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