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Effect of the histone deacetylase inhibitors on behavioural sensitization to a single morphine exposure in mice
Jing, Li2; Luo, Juan1; Zhang, Min1; Qin, Wang-Jun1; Li, Yu-Ling1; Liu, Qing1; Wang, Yan-Ting1; Lawrence, Andrew J.3,4; Liang, Jian-Hui1
关键词Morphine Histone Deacetylase Inhibitor Sodium Butyrate Valproic Acid Behavioural Sensitization
刊名NEUROSCIENCE LETTERS
2011-04-25
DOI10.1016/j.neulet.2011.03.005
494期:2页:169-173
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
资助者National Nature Science Foundation of China ; National Basic Research Program of China ; China Ministry of Education (State Key Laboratory of Natural and Biomimetic Drugs, Peking University) ; Tianjin Medical University Science Foundation of China ; National Health &amp ; Medical Research Council (Australia) ; National Nature Science Foundation of China ; National Basic Research Program of China ; China Ministry of Education (State Key Laboratory of Natural and Biomimetic Drugs, Peking University) ; Tianjin Medical University Science Foundation of China ; National Health &amp ; Medical Research Council (Australia)
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]VALPROIC ACID ; NEUROCHEMICAL SENSITIZATION ; COCAINE ; EXPRESSION ; ADDICTION ; AMPHETAMINE ; INDUCTION ; RATS ; MECHANISMS ; PLASTICITY
英文摘要

Behavioural sensitization to a single morphine exposure has been considered to be a long-term form of behavioural plasticity associated with opioid addiction. Accumulated evidence has shown that histone modification plays a key role in behavioural plasticity. Therefore, this study was designed to investigate whether the histone deacetylase inhibitors sodium butyrate (SB) and valproic acid (VPA) could disrupt behavioural sensitization to a single morphine exposure. Mice were pretreated with a single injection of morphine and elicited subsequent behavioural sensitization by a challenge-dosage of morphine after a 7-day drug-free period. At doses that did not affect the locomotor activity, both SB and VPA inhibited the acute morphine induced hyperactivity and significantly attenuated the development of behavioural sensitization to a single morphine exposure. Furthermore, the combination of SB and VPA at the sub-effective doses could additionally reduce the development of morphine sensitization. Western blot analysis revealed that multiple administration with the effective dose of SB (160 mg/kg, i.p.) or VPA (150 mg/kg, i.p.) in the behavioural experiments induced hyperacetylation of histone H3 in the NAc of mice. Taken together, these findings suggest that histone acetylation may be involved in morphine sensitization. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

语种英语
所属项目编号30570653 ; 30870894 ; 2003CB515400 ; 2009CB522000 ; 2010ky02
资助者National Nature Science Foundation of China ; National Basic Research Program of China ; China Ministry of Education (State Key Laboratory of Natural and Biomimetic Drugs, Peking University) ; Tianjin Medical University Science Foundation of China ; National Health &amp ; Medical Research Council (Australia) ; National Nature Science Foundation of China ; National Basic Research Program of China ; China Ministry of Education (State Key Laboratory of Natural and Biomimetic Drugs, Peking University) ; Tianjin Medical University Science Foundation of China ; National Health &amp ; Medical Research Council (Australia)
WOS记录号WOS:000290013100017
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52689
Collection中国药物依赖性研究所
作者单位1.Howard Florey Inst, Parkville, Vic 3010, Australia
2.Ctr Neurosci, Parkville, Vic 3010, Australia
3.Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100191, Peoples R China
4.Tianjin Med Univ, Dept Physiol, Tianjin 30070, Peoples R China
Recommended Citation
GB/T 7714
Jing, Li,Luo, Juan,Zhang, Min,et al. Effect of the histone deacetylase inhibitors on behavioural sensitization to a single morphine exposure in mice[J]. NEUROSCIENCE LETTERS,2011,494(2):169-173.
APA Jing, Li.,Luo, Juan.,Zhang, Min.,Qin, Wang-Jun.,Li, Yu-Ling.,...&Liang, Jian-Hui.(2011).Effect of the histone deacetylase inhibitors on behavioural sensitization to a single morphine exposure in mice.NEUROSCIENCE LETTERS,494(2),169-173.
MLA Jing, Li,et al."Effect of the histone deacetylase inhibitors on behavioural sensitization to a single morphine exposure in mice".NEUROSCIENCE LETTERS 494.2(2011):169-173.
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