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学科主题基础医学
Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms
Lin, ZB; Zhang, HN
关键词Ganoderma Lucidum Polysaccharides Triterpene Immunomodulatory Activities Anti-tumor Activities
刊名ACTA PHARMACOLOGICA SINICA
2004-11-01
25期:11页:1387-1395
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]WATER-SOLUBLE EXTRACT ; CELL-CYCLE ARREST ; REI-SHI MYCELIA ; POLYSACCHARIDES PEPTIDE ; DENDRITIC CELLS ; CULTURED MEDIUM ; T-LYMPHOCYTES ; CHINESE HERB ; TUMOR-CELLS ; MICE
英文摘要

Ganoderma lucidum (G lucidum) is a medicinal fungus with a variety of biological activities. It has long been used as a folk remedy for promotion of health and longevity in China and other oriental countries. The most attractive character of this kind of medicinal fungus is its immunomodulatory and anti-tumor activities. Large numbers of studies have shown that G lucidum modulate many components of the immune system such as the antigen-presenting cells, NK cells, T and B lymphocytes. The water extract and the polysaccharides fraction of G lucidum exhibited significant anti-tumor effect in several tumor-bearing animals mainly through its immunoenhancing activity. Recent studies also showed that the alcohol extract or the triterpene fraction of G lucidum possessed antitumor effect, which seemed to be related to the cytotoxic activity against tumor cells directly. Preliminary study indicated that antiangiogenic effect may be involved antitumor activity of G lucidum.

语种英语
WOS记录号WOS:000224947400001
引用统计
被引频次:194[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52696
专题北京大学基础医学院_药理学系
北京大学基础医学院
作者单位Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
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GB/T 7714
Lin, ZB,Zhang, HN. Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms[J]. ACTA PHARMACOLOGICA SINICA,2004,25(11):1387-1395.
APA Lin, ZB,&Zhang, HN.(2004).Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms.ACTA PHARMACOLOGICA SINICA,25(11),1387-1395.
MLA Lin, ZB,et al."Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms".ACTA PHARMACOLOGICA SINICA 25.11(2004):1387-1395.
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