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学科主题: 基础医学
题名:
Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms
作者: Lin, ZB; Zhang, HN
关键词: Ganoderma lucidum ; polysaccharides ; triterpene ; immunomodulatory activities ; anti-tumor activities
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2004-11-01
卷: 25, 期:11, 页:1387-1395
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: WATER-SOLUBLE EXTRACT ; CELL-CYCLE ARREST ; REI-SHI MYCELIA ; POLYSACCHARIDES PEPTIDE ; DENDRITIC CELLS ; CULTURED MEDIUM ; T-LYMPHOCYTES ; CHINESE HERB ; TUMOR-CELLS ; MICE
英文摘要:

Ganoderma lucidum (G lucidum) is a medicinal fungus with a variety of biological activities. It has long been used as a folk remedy for promotion of health and longevity in China and other oriental countries. The most attractive character of this kind of medicinal fungus is its immunomodulatory and anti-tumor activities. Large numbers of studies have shown that G lucidum modulate many components of the immune system such as the antigen-presenting cells, NK cells, T and B lymphocytes. The water extract and the polysaccharides fraction of G lucidum exhibited significant anti-tumor effect in several tumor-bearing animals mainly through its immunoenhancing activity. Recent studies also showed that the alcohol extract or the triterpene fraction of G lucidum possessed antitumor effect, which seemed to be related to the cytotoxic activity against tumor cells directly. Preliminary study indicated that antiangiogenic effect may be involved antitumor activity of G lucidum.

语种: 英语
WOS记录号: WOS:000224947400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52696
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China

Recommended Citation:
Lin, ZB,Zhang, HN. Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms[J]. ACTA PHARMACOLOGICA SINICA,2004,25(11):1387-1395.
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