学科主题临床医学
Expression of TASK-1 in brainstem and the occurrence of central sleep apnea in rats
Wang, Jing; Zhang, Cheng; Li, Nan; Su, Li; Wang, GuangFa
关键词Task-1 Central Chemoreceptors Rat Central Sleep Apnea Control Of Breathing
刊名RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
2008-03-20
DOI10.1016/j.resp.2007.11.008
161期:1页:23-28
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Physiology ; Respiratory System
研究领域[WOS]Physiology ; Respiratory System
关键词[WOS]K+ CHANNEL ; RESPIRATORY CONTROL ; NEURONS ; INSTABILITY ; MODULATION ; NUCLEUS ; HUMANS ; REFLEX ; MODEL ; REM
英文摘要

Recent studies revealed that unstable ventilation control is one of mechanisms underlying the occurrence of sleep apnea. Thus, we investigated whether TASK-1, an acid-sensitive potassium channel, plays a role in the occurrence of sleep apnea. First, the expression of TASK-I transcriptions on brainstem was checked by in situ hybridization. Then, the correlation between the central apneic episodes and protein contents of TASK-1 measured by western blot was analyzed from 27 male rats. Results showed that TASK-1 mRNAs were widely distributed on the putative central chemoreceptors such as locus coeruleus, nucleus tractus solitarius and medullary raphe, etc. Both the total spontaneous apnea index (TSAI) and spontaneous apnea index in NREM sleep (NSAI) were positively correlated with TASK-1 protein contents (r=0.547 and 0.601, respectively, p <0.01). However, the post-sigh sleep apnea index (PAI) had no relationship with TASK-I protein. Thus, we concluded that TASK-1 channels may function as central chemoreceptors that play a role in spontaneous sleep apneas in rats. (C) 2008 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000255267900004
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52709
专题北京大学第一临床医学院_呼吸和危重症医学科
北京大学第一临床医学院_呼吸科
作者单位Peking Univ, Dept Pulm Med, Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Wang, Jing,Zhang, Cheng,Li, Nan,et al. Expression of TASK-1 in brainstem and the occurrence of central sleep apnea in rats[J]. RESPIRATORY PHYSIOLOGY &amp; NEUROBIOLOGY,2008,161(1):23-28.
APA Wang, Jing,Zhang, Cheng,Li, Nan,Su, Li,&Wang, GuangFa.(2008).Expression of TASK-1 in brainstem and the occurrence of central sleep apnea in rats.RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY,161(1),23-28.
MLA Wang, Jing,et al."Expression of TASK-1 in brainstem and the occurrence of central sleep apnea in rats".RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY 161.1(2008):23-28.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Jing]的文章
[Zhang, Cheng]的文章
[Li, Nan]的文章
百度学术
百度学术中相似的文章
[Wang, Jing]的文章
[Zhang, Cheng]的文章
[Li, Nan]的文章
必应学术
必应学术中相似的文章
[Wang, Jing]的文章
[Zhang, Cheng]的文章
[Li, Nan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。