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学科主题: 临床医学
题名:
Expression of TASK-1 in brainstem and the occurrence of central sleep apnea in rats
作者: Wang, Jing; Zhang, Cheng; Li, Nan; Su, Li; Wang, GuangFa
关键词: TASK-1 ; central chemoreceptors ; rat ; central sleep apnea ; control of breathing
刊名: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
发表日期: 2008-03-20
DOI: 10.1016/j.resp.2007.11.008
卷: 161, 期:1, 页:23-28
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Physiology ; Respiratory System
研究领域[WOS]: Physiology ; Respiratory System
关键词[WOS]: K+ CHANNEL ; RESPIRATORY CONTROL ; NEURONS ; INSTABILITY ; MODULATION ; NUCLEUS ; HUMANS ; REFLEX ; MODEL ; REM
英文摘要:

Recent studies revealed that unstable ventilation control is one of mechanisms underlying the occurrence of sleep apnea. Thus, we investigated whether TASK-1, an acid-sensitive potassium channel, plays a role in the occurrence of sleep apnea. First, the expression of TASK-I transcriptions on brainstem was checked by in situ hybridization. Then, the correlation between the central apneic episodes and protein contents of TASK-1 measured by western blot was analyzed from 27 male rats. Results showed that TASK-1 mRNAs were widely distributed on the putative central chemoreceptors such as locus coeruleus, nucleus tractus solitarius and medullary raphe, etc. Both the total spontaneous apnea index (TSAI) and spontaneous apnea index in NREM sleep (NSAI) were positively correlated with TASK-1 protein contents (r=0.547 and 0.601, respectively, p <0.01). However, the post-sigh sleep apnea index (PAI) had no relationship with TASK-I protein. Thus, we concluded that TASK-1 channels may function as central chemoreceptors that play a role in spontaneous sleep apneas in rats. (C) 2008 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000255267900004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52709
Appears in Collections:北京大学第一临床医学院_呼吸和危重症医学科_期刊论文

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作者单位: Peking Univ, Dept Pulm Med, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Wang, Jing,Zhang, Cheng,Li, Nan,et al. Expression of TASK-1 in brainstem and the occurrence of central sleep apnea in rats[J]. RESPIRATORY PHYSIOLOGY &amp; NEUROBIOLOGY,2008,161(1):23-28.
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