北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 期刊论文
学科主题: 公共卫生
题名:
Effects of chronic chromium(VI) exposure on blood element homeostasis: An epidemiological study
作者: Song, Yanshuang1; Zhang, Ji2; Yu, Shanfa3; Wang, Tiancheng4; Cui, Xiaoxing1; Du, Xianmei1; Jia, Guang1
刊名: METALLOMICS
发表日期: 2012
DOI: 10.1039/c2mt20051a
卷: 4, 期:5, 页:463-472
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: TRACE-ELEMENTS ; OCCUPATIONAL-EXPOSURE ; HYDROGEN-PEROXIDE ; OXIDATIVE STRESS ; DNA-DAMAGE ; HEXAVALENT CHROMIUM ; ANTIOXIDANT ENZYMES ; TANNERY WORKERS ; LUNG-CANCER ; ZINC LEVELS
英文摘要:

One hundred chromate production workers chronically exposed to low-level of hexavalent chromium [Cr(VI)] and eighty healthy individuals free from Cr exposure were recruited to the study. Personal sampling of airborne Cr was conducted and Cr content was quantified by Flame Atomic Absorption Spectrometry (FAAS). At the end of the sampling shift, blood samples were collected and element concentrations were measured by inductively coupled plasma mass spectrometry (ICP-MS) for Cr, Cd, Cu, Mo and Se and inductively coupled plasma atomic emission spectrometry (ICP-AES) for Ca, Fe, Mg and Zn. According to our results, 90% of the chromate production workers were exposed to airborne Cr in a concentration lower than 50 mu g m(-3), which is the threshold limit value recommended by the American Conference of Governmental Industrial Hygienists and Chinese Ministry of Health. After Cr(VI) exposure, a significant increase in blood Cr, Cd, Fe, Mg, Mo, Se and Zn concentrations was observed, as well as a significant decrease in Ca concentration. A decrease in blood Cu was only observed among female workers. Blood Cr concentrations of the exposed workers (median = 15.68 ng mL(-1)) was four times higher than that of the controls (median = 3.03 ng mL(-1)), and significantly correlated with airborne Cr (r = 0.568, P<0.001). In addition, the inter-element correlations exhibited significant differences between the two groups. Our findings of the related health effects suggested that the underlying mechanisms of chronic Cr(VI) exposure on blood element homeostasis might be partly explained by oxidative stress in the body, dysfunction of Fe metabolism and renal injury.

语种: 英语
所属项目编号: 81072281 ; 200902006
项目资助者: National Natural Science Foundation of China ; Chinese Ministry of Health
WOS记录号: WOS:000303501500009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52711
Appears in Collections:北京大学公共卫生学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Dept Occupat & Environm Hlth Sci, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Jinan Municipal Ctr Dis Control & Prevent, Jinan 250013, Shandong, Peoples R China
3.Henan Prov Inst Occupat Med, Zhengzhou 450052, Henan Province, Peoples R China
4.Peking Univ, Dept Clin Labs, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Song, Yanshuang,Zhang, Ji,Yu, Shanfa,et al. Effects of chronic chromium(VI) exposure on blood element homeostasis: An epidemiological study[J]. METALLOMICS,2012,4(5):463-472.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Song, Yanshuang]'s Articles
[Zhang, Ji]'s Articles
[Yu, Shanfa]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Song, Yanshuang]‘s Articles
[Zhang, Ji]‘s Articles
[Yu, Shanfa]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace