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Effects of chronic chromium(VI) exposure on blood element homeostasis: An epidemiological study
Song, Yanshuang1; Zhang, Ji2; Yu, Shanfa3; Wang, Tiancheng4; Cui, Xiaoxing1; Du, Xianmei1; Jia, Guang1
刊名METALLOMICS
2012
DOI10.1039/c2mt20051a
4期:5页:463-472
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]TRACE-ELEMENTS ; OCCUPATIONAL-EXPOSURE ; HYDROGEN-PEROXIDE ; OXIDATIVE STRESS ; DNA-DAMAGE ; HEXAVALENT CHROMIUM ; ANTIOXIDANT ENZYMES ; TANNERY WORKERS ; LUNG-CANCER ; ZINC LEVELS
英文摘要

One hundred chromate production workers chronically exposed to low-level of hexavalent chromium [Cr(VI)] and eighty healthy individuals free from Cr exposure were recruited to the study. Personal sampling of airborne Cr was conducted and Cr content was quantified by Flame Atomic Absorption Spectrometry (FAAS). At the end of the sampling shift, blood samples were collected and element concentrations were measured by inductively coupled plasma mass spectrometry (ICP-MS) for Cr, Cd, Cu, Mo and Se and inductively coupled plasma atomic emission spectrometry (ICP-AES) for Ca, Fe, Mg and Zn. According to our results, 90% of the chromate production workers were exposed to airborne Cr in a concentration lower than 50 mu g m(-3), which is the threshold limit value recommended by the American Conference of Governmental Industrial Hygienists and Chinese Ministry of Health. After Cr(VI) exposure, a significant increase in blood Cr, Cd, Fe, Mg, Mo, Se and Zn concentrations was observed, as well as a significant decrease in Ca concentration. A decrease in blood Cu was only observed among female workers. Blood Cr concentrations of the exposed workers (median = 15.68 ng mL(-1)) was four times higher than that of the controls (median = 3.03 ng mL(-1)), and significantly correlated with airborne Cr (r = 0.568, P<0.001). In addition, the inter-element correlations exhibited significant differences between the two groups. Our findings of the related health effects suggested that the underlying mechanisms of chronic Cr(VI) exposure on blood element homeostasis might be partly explained by oxidative stress in the body, dysfunction of Fe metabolism and renal injury.

语种英语
WOS记录号WOS:000303501500009
项目编号81072281 ; 200902006
资助机构National Natural Science Foundation of China ; Chinese Ministry of Health
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52711
专题北京大学公共卫生学院
北京大学医学部管理机构_科学研究处
北京大学公共卫生学院_公共卫生学院
作者单位1.Peking Univ, Dept Occupat & Environm Hlth Sci, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Jinan Municipal Ctr Dis Control & Prevent, Jinan 250013, Shandong, Peoples R China
3.Henan Prov Inst Occupat Med, Zhengzhou 450052, Henan Province, Peoples R China
4.Peking Univ, Dept Clin Labs, Hosp 3, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Song, Yanshuang,Zhang, Ji,Yu, Shanfa,et al. Effects of chronic chromium(VI) exposure on blood element homeostasis: An epidemiological study[J]. METALLOMICS,2012,4(5):463-472.
APA Song, Yanshuang.,Zhang, Ji.,Yu, Shanfa.,Wang, Tiancheng.,Cui, Xiaoxing.,...&Jia, Guang.(2012).Effects of chronic chromium(VI) exposure on blood element homeostasis: An epidemiological study.METALLOMICS,4(5),463-472.
MLA Song, Yanshuang,et al."Effects of chronic chromium(VI) exposure on blood element homeostasis: An epidemiological study".METALLOMICS 4.5(2012):463-472.
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