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学科主题: 药学
题名:
Copper-Catalyzed Aerobic Dehydrogenation of C-C to C=C Bonds in the Synthesis of Pyridazinones
作者: Liang, Lei; Yang, Guanyu; Xu, Fengrong; Niu, Yan; Sun, Qi; Xu, Ping
关键词: Medicinal chemistry ; Drug discovery ; Dehydrogenation ; Nitrogen heterocycles ; Copper
刊名: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
发表日期: 2013-09-01
DOI: 10.1002/ejoc.201300640
卷: 2013, 期:27, 页:6130-6136
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: POSITIVE INOTROPIC AGENTS ; CARDIOTONIC AGENTS ; ALKANE DEHYDROGENATION ; RECEPTOR ANTAGONISTS ; ORGANIC-CHEMICALS ; POTENT ; OPTIMIZATION ; INHIBITORS ; COMPLEXES ; IRIDIUM
英文摘要:

A simple and efficient procedure for the synthesis of pyridazin-3(2H)-ones through copper-catalyzed dehydrogenation of a single C-C bond of 4,5-dihydropyridazin-3(2H)-ones to a C=C bond with oxygen as the terminal oxidant is described. Functional groups including hydroxy, carboxylic, bromo, chloro, cyano, nitro and alkoxy were all tolerated under the reaction conditions. Moreover, this methodology was applied to the preparation of a series of structurally similar N-substituted 6-phenylpyridazinone compounds containing fluorine. The dehydrogenation reactions exhibit good yields and selectivity.

语种: 英语
所属项目编号: 7112088 ; 2012CB518000 ; 21202003/21172012
项目资助者: Beijing Natural Science Foundation ; National Basic Research Program of China ; National Natural Science Foundation of China (NSFC)
WOS记录号: WOS:000324302600018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52714
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs,Dept Med Chem, Beijing 100191, Peoples R China

Recommended Citation:
Liang, Lei,Yang, Guanyu,Xu, Fengrong,et al. Copper-Catalyzed Aerobic Dehydrogenation of C-C to C=C Bonds in the Synthesis of Pyridazinones[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2013,2013(27):6130-6136.
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