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Synthetic double-stranded RNA polyinosinic-polycytidylic acid augments morphine-induced conditioned place preference in rats
Zhang, Lei2; Chen, Suqing1; Liu, Hongyu2; Lu, Lin1; Zhai, Haifeng1
关键词Conditioned Place Preference Immune Challenge Opiate Poly i:-c Rat
刊名BEHAVIOURAL PHARMACOLOGY
2010-07-01
DOI10.1097/FBP.0b013e32833c7ce5
21期:4页:369-373
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]INTERFERON-ALPHA ; POLY I ; CYTOKINES ; OPIATE ; MODULATION ; RECEPTORS ; MECHANISM ; INFECTION ; DRUGS ; AXIS
英文摘要

Three experiments were performed to study the effects of immune challenge on the rewarding properties of opiates. Intraperitoneal injection of polyinosinic-polycytidylic acid (Poly I: C, 1 mg/kg) was used to trigger an immune challenge. Conditioned place preference (CPP) in rats trained with alternating subcutaneous injections of morphine (5 mg/kg) and saline was used to assess the rewarding effect of morphine. Poly I: C administered before CPP training had no effects on CPP acquisition. Poly I: C administered during CPP training enhanced CPP acquisition. Poly I: C administered after morphine-induced CPP acquisition retarded CPP extinction. These results show that the immune challenge by Poly I: C augmented morphine CPP in rats depending on the onset time of the challenge. The findings suggest that immune challenge may enhance the rewarding properties of opiates. Behavioural Pharmacology 21: 369-373 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.

语种英语
WOS记录号WOS:000280186400012
项目编号30873051 ; 2007CB512302
资助机构National Science Foundation ; National Basic Research Program ; Scientific Research Foundation for Returned Overseas Chinese Scholars from the State Education Ministry, of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52718
专题中国药物依赖性研究所
作者单位1.Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100191, Peoples R China
2.N Univ China, Sch Informat & Commun Engn, Taiyuan, Peoples R China
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GB/T 7714
Zhang, Lei,Chen, Suqing,Liu, Hongyu,et al. Synthetic double-stranded RNA polyinosinic-polycytidylic acid augments morphine-induced conditioned place preference in rats[J]. BEHAVIOURAL PHARMACOLOGY,2010,21(4):369-373.
APA Zhang, Lei,Chen, Suqing,Liu, Hongyu,Lu, Lin,&Zhai, Haifeng.(2010).Synthetic double-stranded RNA polyinosinic-polycytidylic acid augments morphine-induced conditioned place preference in rats.BEHAVIOURAL PHARMACOLOGY,21(4),369-373.
MLA Zhang, Lei,et al."Synthetic double-stranded RNA polyinosinic-polycytidylic acid augments morphine-induced conditioned place preference in rats".BEHAVIOURAL PHARMACOLOGY 21.4(2010):369-373.
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