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学科主题: 药物依赖
题名:
Synthetic double-stranded RNA polyinosinic-polycytidylic acid augments morphine-induced conditioned place preference in rats
作者: Zhang, Lei2; Chen, Suqing1; Liu, Hongyu2; Lu, Lin1; Zhai, Haifeng1
关键词: conditioned place preference ; immune challenge ; opiate ; Poly I:-C ; rat
刊名: BEHAVIOURAL PHARMACOLOGY
发表日期: 2010-07-01
DOI: 10.1097/FBP.0b013e32833c7ce5
卷: 21, 期:4, 页:369-373
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: INTERFERON-ALPHA ; POLY I ; CYTOKINES ; OPIATE ; MODULATION ; RECEPTORS ; MECHANISM ; INFECTION ; DRUGS ; AXIS
英文摘要:

Three experiments were performed to study the effects of immune challenge on the rewarding properties of opiates. Intraperitoneal injection of polyinosinic-polycytidylic acid (Poly I: C, 1 mg/kg) was used to trigger an immune challenge. Conditioned place preference (CPP) in rats trained with alternating subcutaneous injections of morphine (5 mg/kg) and saline was used to assess the rewarding effect of morphine. Poly I: C administered before CPP training had no effects on CPP acquisition. Poly I: C administered during CPP training enhanced CPP acquisition. Poly I: C administered after morphine-induced CPP acquisition retarded CPP extinction. These results show that the immune challenge by Poly I: C augmented morphine CPP in rats depending on the onset time of the challenge. The findings suggest that immune challenge may enhance the rewarding properties of opiates. Behavioural Pharmacology 21: 369-373 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.

语种: 英语
所属项目编号: 30873051 ; 2007CB512302
项目资助者: National Science Foundation ; National Basic Research Program ; Scientific Research Foundation for Returned Overseas Chinese Scholars from the State Education Ministry, of China
WOS记录号: WOS:000280186400012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52718
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100191, Peoples R China
2.N Univ China, Sch Informat & Commun Engn, Taiyuan, Peoples R China

Recommended Citation:
Zhang, Lei,Chen, Suqing,Liu, Hongyu,et al. Synthetic double-stranded RNA polyinosinic-polycytidylic acid augments morphine-induced conditioned place preference in rats[J]. BEHAVIOURAL PHARMACOLOGY,2010,21(4):369-373.
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