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学科主题: 药学
题名:
Chiral 1,2-diaminocyclohexane as organocatalyst for enantioselective aldol reaction
作者: Liu, Yi; Wang, Junfeng; Sun, Qi; Li, Runtao
关键词: Asymmetric aldol reaction ; Diaminocyclohexane ; Organocatalyst ; Hydroxyketone
刊名: TETRAHEDRON LETTERS
发表日期: 2011-07-13
DOI: 10.1016/j.tetlet.2011.04.116
卷: 52, 期:28, 页:3584-3587
收录类别: SCI ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: L-PROLINAMIDE DERIVATIVES ; LINEAR ALIPHATIC-KETONES ; DIRECT SYN-ALDOL ; AQUEOUS-MEDIA ; AMINO-ACID ; ORGANIC-MOLECULES ; SMALL PEPTIDES ; CATALYSTS ; HYDROXYACETONE ; ALDEHYDES
英文摘要:

A simple and commercially available chiral 1,2-diaminocyclohexane as catalyst, hexanedioic acid as co-catalyst could efficiently catalyze the asymmetric aldol reaction in MeOH-H(2)O. Cyclic ketones as aldol substrates gave the anti-beta-hydroxyketone products with moderate to good yields, diastereoselectivity and enantioselectivity (up to 78% yield, >20:1 anti/syn, 94% ee). Hydroxyacetone as aldol substrate afforded the syn-alpha, beta-dihydroxyketones as major products in up to 85% yield with good enantioselectivity (up to >20:1 syn/anti, 93% ee). (C) 2011 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 20972005
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000292351000011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52724
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Liu, Yi,Wang, Junfeng,Sun, Qi,et al. Chiral 1,2-diaminocyclohexane as organocatalyst for enantioselective aldol reaction[J]. TETRAHEDRON LETTERS,2011,52(28):3584-3587.
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