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学科主题: 临床医学
题名:
Alterations of nitrate and nitrite content in saliva, serum, and urine in patients with salivary dysfunction
作者: Xia, DS1; Deng, DJ1; Wang, SL1
关键词: nitrate ; nitrite ; saliva ; sialosis ; Sjogren&prime ; s syndrome
刊名: JOURNAL OF ORAL PATHOLOGY & MEDICINE
发表日期: 2003-02-01
卷: 32, 期:2, 页:95-99
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine ; Pathology
研究领域[WOS]: Dentistry, Oral Surgery & Medicine ; Pathology
关键词[WOS]: DIETARY NITRATE ; SJOGRENS-SYNDROME ; OXIDE ; CIRCULATION ; INGESTION ; CANCER
英文摘要:

Background: The role of the salivary glands in the maintenance of nitrate and nitrite in saliva is poorly understood. The aim was to study alterations of nitrate and nitrite metabolisms in patients with Sjogren′s syndrome (SS) or sialosis.

Methods: Saliva, serum, and urine samples were collected from healthy volunteers (n = 29), patients with SS (n = 31), and patients with sialosis (n = 30). Concentrations of nitrate and nitrite were determined by high-performance liquid chromatography (HPLC).

Results: In the healthy group, the highest concentration of nitrate was found in parotid saliva (172 mg/l), followed by urine (160 mg/l), whole saliva (97 mg/l), and serum (33 mg/l). In the SS group, concentration of nitrate was decreased in parotid saliva and whole saliva, and increased significantly in urine. Concentration of nitrite in whole saliva was significantly decreased in the SS group and increased in the sialosis group.

Conclusion: Hypofunction of the salivary glands is associated with significant changes of nitrate and nitrite levels in the saliva and urine.

语种: 英语
WOS记录号: WOS:000180606800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52726
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing 100034, Peoples R China
2.Beijing Inst Canc Res, Beijing 100034, Peoples R China
3.Capital Univ Med Sci, Fac Stomatol, Salivary Gland Dis Ctr, Beijing 100050, Peoples R China

Recommended Citation:
Xia, DS,Deng, DJ,Wang, SL. Alterations of nitrate and nitrite content in saliva, serum, and urine in patients with salivary dysfunction[J]. JOURNAL OF ORAL PATHOLOGY & MEDICINE,2003,32(2):95-99.
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