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Assessment of shikonin for potential estrogenic activity by dual-luciferase reporter based bioluminescent measurements in vitro
Zhang, Yi2,3; Li, Ping-Ping1
刊名PHARMAZIE
2011-02-01
DOI10.1691/ph.2011.0714
66期:2页:141-143
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]STEROID SULFATASE GENES ; LITHOSPERMUM-ERYTHRORHIZON ; CELLS ; PHARMACOLOGY ; ACTIVATION ; MECHANISMS ; EXPRESSION ; EXTRACT ; CANCER
英文摘要

Shikonin, an active component of Lithospermum erythrorhizon Sieb. et Zucc., shows multiple pharmacological properties. However, the estrogenic activity of shikonin is remaining unclear. We assessed the potential estrogenic activity of shikonin with dual-luciferase reporter assay and bioluminescent measurements, by using transient cotransfection with estrogen dependent plasmid pERE-TK-Luc and internal control plasmid pRL-TK in MCF-7 cells. Estrogenic activity of shikonin, even at high concentration did not alter significantly compared to negative control (p > 0.05) and were significantly lower than those with E-2 (p < 0.01). Concluding, shikonin demonstrates no estrogenic activity in vitro.

语种英语
WOS记录号WOS:000288052700010
项目编号2004-IV15
资助机构Key Program Foundation of Beijing Administration of TCMs, China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52729
专题北京大学基础医学院
北京大学临床肿瘤学院_中西医结合科暨老年肿瘤科
作者单位1.Peking Univ, Dept Integrated Tradit Chinese & Western Med, Key Lab Carcinogenesis & Translat Res,Minist Educ, Sch Oncol,Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
2.Beijing Univ Chinese Med, Dept Anat, Sch Preclin Med, Beijing, Peoples R China
3.Peking Univ, Dept Integrated Tradit Chinese & Western Med, Sch Basic Med Sci, Beijing 100142, Peoples R China
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Zhang, Yi,Li, Ping-Ping. Assessment of shikonin for potential estrogenic activity by dual-luciferase reporter based bioluminescent measurements in vitro[J]. PHARMAZIE,2011,66(2):141-143.
APA Zhang, Yi,&Li, Ping-Ping.(2011).Assessment of shikonin for potential estrogenic activity by dual-luciferase reporter based bioluminescent measurements in vitro.PHARMAZIE,66(2),141-143.
MLA Zhang, Yi,et al."Assessment of shikonin for potential estrogenic activity by dual-luciferase reporter based bioluminescent measurements in vitro".PHARMAZIE 66.2(2011):141-143.
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