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学科主题: 临床医学
题名:
Decrease in the production of beta-amyloid by berberine inhibition of the expression of beta-secretase in HEK293 cells
作者: Zhu, Feiqi1,2; Wu, Fujun3; Ma, Ying4; Liu, Guangjian2; Li, Zhong5; Sun, Yong&prime1; an6; Pei, Zhong5
关键词: Alzheimer&prime ; s disease ; berberine ; beta-amyloid(40/42) ; beta-secretase ; extracellular signal-regulated kinase1/2
刊名: BMC NEUROSCIENCE
发表日期: 2011-12-12
DOI: 10.1186/1471-2202-12-125
卷: 12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: NONSTEROIDAL ANTIINFLAMMATORY DRUGS ; ALZHEIMERS-DISEASE ; IN-VITRO ; COPTIDIS-RHIZOMA ; CANCER-CELLS ; GLUCOSE-METABOLISM ; MECHANISM DISTINCT ; PRECURSOR PROTEIN ; NITRIC-OXIDE ; RAT MODEL
英文摘要:

Background: Berberine (BER), the major alkaloidal component of Rhizoma coptidis, has multiple pharmacological effects including inhibition of acetylcholinesterase, reduction of cholesterol and glucose levels, anti-inflammatory, neuroprotective and neurotrophic effects. It has also been demonstrated that BER can reduce the production of beta-amyloid(40/42), which plays a critical and primary role in the pathogenesis of Alzheimer′s disease. However, the mechanism by which it accomplishes this remains unclear.

Results: Here, we report that BER could not only significantly decrease the production of beta-amyloid40/42 and the expression of beta-secretase (BACE), but was also able to activate the extracellular signal-regulated kinase1/2 (ERK1/2) pathway in a dose-and time-dependent manner in HEK293 cells stably transfected with APP695 containing the Swedish mutation. We also find that U0126, an antagonist of the ERK1/2 pathway, could abolish (1) the activation activity of BER on the ERK1/2 pathway and (2) the inhibition activity of BER on the production of beta-amyloid(40/42) and the expression of BACE.

Conclusion: Our data indicate that BER decreases the production of beta-amyloid(40/42) by inhibiting the expression of BACE via activation of the ERK1/2 pathway.

语种: 英语
所属项目编号: 30800359
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000298912500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52731
Appears in Collections:北京大学第一临床医学院_神经内科_期刊论文

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作者单位: 1.Shantou Univ, Coll Med, Dept Neurol, Affiliated Yuebei Peoples Hosp, Shaoguan 512026, Guangdong, Peoples R China
2.Hubei Univ Med, Affiliated Hosp, Dept Neurol, Taihe Hosp, Shiyan 442000, Hubei, Peoples R China
3.Anhui Agr Univ, Coll Life Sci, Hefei 230036, Anhui, Peoples R China
4.Shantou Univ, Coll Med, Dept Cardiol, Affiliated Yuebei Peoples Hosp, Shaoguan 512026, Guangdong, Peoples R China
5.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Neurol, Guangzhou 510080, Guangdong, Peoples R China
6.Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China

Recommended Citation:
Zhu, Feiqi,Wu, Fujun,Ma, Ying,et al. Decrease in the production of beta-amyloid by berberine inhibition of the expression of beta-secretase in HEK293 cells[J]. BMC NEUROSCIENCE,2011,12.
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