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Decrease in the production of beta-amyloid by berberine inhibition of the expression of beta-secretase in HEK293 cells
Zhu, Feiqi1,2; Wu, Fujun3; Ma, Ying4; Liu, Guangjian2; Li, Zhong5; Sun, Yong&prime1; an6; Pei, Zhong5
关键词Alzheimer&Prime s Disease Berberine Beta-amyloid(40/42) Beta-secretase Extracellular Signal-regulated Kinase1/2
刊名BMC NEUROSCIENCE
2011-12-12
DOI10.1186/1471-2202-12-125
12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]NONSTEROIDAL ANTIINFLAMMATORY DRUGS ; ALZHEIMERS-DISEASE ; IN-VITRO ; COPTIDIS-RHIZOMA ; CANCER-CELLS ; GLUCOSE-METABOLISM ; MECHANISM DISTINCT ; PRECURSOR PROTEIN ; NITRIC-OXIDE ; RAT MODEL
英文摘要

Background: Berberine (BER), the major alkaloidal component of Rhizoma coptidis, has multiple pharmacological effects including inhibition of acetylcholinesterase, reduction of cholesterol and glucose levels, anti-inflammatory, neuroprotective and neurotrophic effects. It has also been demonstrated that BER can reduce the production of beta-amyloid(40/42), which plays a critical and primary role in the pathogenesis of Alzheimer′s disease. However, the mechanism by which it accomplishes this remains unclear.

Results: Here, we report that BER could not only significantly decrease the production of beta-amyloid40/42 and the expression of beta-secretase (BACE), but was also able to activate the extracellular signal-regulated kinase1/2 (ERK1/2) pathway in a dose-and time-dependent manner in HEK293 cells stably transfected with APP695 containing the Swedish mutation. We also find that U0126, an antagonist of the ERK1/2 pathway, could abolish (1) the activation activity of BER on the ERK1/2 pathway and (2) the inhibition activity of BER on the production of beta-amyloid(40/42) and the expression of BACE.

Conclusion: Our data indicate that BER decreases the production of beta-amyloid(40/42) by inhibiting the expression of BACE via activation of the ERK1/2 pathway.

语种英语
WOS记录号WOS:000298912500001
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52731
专题北京大学第一临床医学院_神经内科
作者单位1.Shantou Univ, Coll Med, Dept Neurol, Affiliated Yuebei Peoples Hosp, Shaoguan 512026, Guangdong, Peoples R China
2.Hubei Univ Med, Affiliated Hosp, Dept Neurol, Taihe Hosp, Shiyan 442000, Hubei, Peoples R China
3.Anhui Agr Univ, Coll Life Sci, Hefei 230036, Anhui, Peoples R China
4.Shantou Univ, Coll Med, Dept Cardiol, Affiliated Yuebei Peoples Hosp, Shaoguan 512026, Guangdong, Peoples R China
5.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Neurol, Guangzhou 510080, Guangdong, Peoples R China
6.Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhu, Feiqi,Wu, Fujun,Ma, Ying,et al. Decrease in the production of beta-amyloid by berberine inhibition of the expression of beta-secretase in HEK293 cells[J]. BMC NEUROSCIENCE,2011,12.
APA Zhu, Feiqi.,Wu, Fujun.,Ma, Ying.,Liu, Guangjian.,Li, Zhong.,...&Pei, Zhong.(2011).Decrease in the production of beta-amyloid by berberine inhibition of the expression of beta-secretase in HEK293 cells.BMC NEUROSCIENCE,12.
MLA Zhu, Feiqi,et al."Decrease in the production of beta-amyloid by berberine inhibition of the expression of beta-secretase in HEK293 cells".BMC NEUROSCIENCE 12(2011).
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