IR@PKUHSC  > 北京大学药学院
学科主题药学
Synthesis of 3-deoxy-3-nucleobase-2,5-anhydro-D-mannitol: a novel class of hydroxymethyl-branched isonucleosides
Lei, Z; Min, JM; Zhang, LH
刊名TETRAHEDRON-ASYMMETRY
2000-07-28
11期:14页:2899-2906
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Inorganic & Nuclear ; Chemistry, Organic ; Chemistry, Physical
研究领域[WOS]Chemistry
关键词[WOS]HUMAN IMMUNODEFICIENCY VIRUS ; ANTI-HIV AGENTS ; ANTIVIRAL ACTIVITY ; PYRIMIDINE ISODIDEOXYNUCLEOSIDES ; ISOMERIC DIDEOXYNUCLEOSIDES ; OXETANOCIN ; NUCLEOSIDES ; DERIVATIVES ; ANALOG
英文摘要

A concise synthesis of 3-deoxy-3-nucleobase-2,5-anhydro-D-mannitol 6(a-d) has been achieved, using the deamination of 2-amino-2-deoxy-D-glucose to construct in one step the sugar skeleton with the desired sense of chirality at each asymmetric center. The selective dibenzoylation of 2,5-anhydro-D-mannitol 9 was investigated, and the key epoxide intermediate 13 was obtained in good yield via an intramolecular Mitsunobu reaction. The process of opening of epoxide 13 by nucleobases appeared to be regioselective. (C) 2000 Elsevier Science Ltd. All rights reserved.

语种英语
WOS记录号WOS:000088856500005
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52734
专题北京大学药学院
作者单位Beijing Med Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Lei, Z,Min, JM,Zhang, LH. Synthesis of 3-deoxy-3-nucleobase-2,5-anhydro-D-mannitol: a novel class of hydroxymethyl-branched isonucleosides[J]. TETRAHEDRON-ASYMMETRY,2000,11(14):2899-2906.
APA Lei, Z,Min, JM,&Zhang, LH.(2000).Synthesis of 3-deoxy-3-nucleobase-2,5-anhydro-D-mannitol: a novel class of hydroxymethyl-branched isonucleosides.TETRAHEDRON-ASYMMETRY,11(14),2899-2906.
MLA Lei, Z,et al."Synthesis of 3-deoxy-3-nucleobase-2,5-anhydro-D-mannitol: a novel class of hydroxymethyl-branched isonucleosides".TETRAHEDRON-ASYMMETRY 11.14(2000):2899-2906.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lei, Z]的文章
[Min, JM]的文章
[Zhang, LH]的文章
百度学术
百度学术中相似的文章
[Lei, Z]的文章
[Min, JM]的文章
[Zhang, LH]的文章
必应学术
必应学术中相似的文章
[Lei, Z]的文章
[Min, JM]的文章
[Zhang, LH]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。