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学科主题: 基础医学
题名:
Expression of nerve growth factor and its receptors TrkA and p75 in the uterus of wild female ground squirrel (Citellus dauricus Brandt)
作者: Li, Ben1; Sheng, Xia1; Song, Moshi2; Zhang, Haolin1; Weng, Jiaju3; Zhang, Mengyuan1; Hu, Xiao4; Zhou, Jiao1; Xu, Meiyu1; Weng, Qiang1,5; Watanabe, Gen5; Taya, Kazuyoshi5
关键词: Wild ground squirrel ; NGF ; p75 ; TrkA ; Uterus
刊名: GENERAL AND COMPARATIVE ENDOCRINOLOGY
发表日期: 2012-03-01
DOI: 10.1016/j.ygcen.2011.12.024
卷: 176, 期:1, 页:62-69
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: INHIBIN ALPHA-SUBUNIT ; GOLDEN-HAMSTERS ; FACTOR NGF ; RAT UTERUS ; INTERSTITIAL-CELLS ; ESTROGEN-RECEPTORS ; NEURAL DEVELOPMENT ; MOUSE UTERUS ; PREGNANCY ; NEUROTROPHINS
英文摘要:

In this study, we investigated the presence of nerve growth factor (NGF) and its receptors tyrosine kinase A (TrkA) and p75 in the uterus of the wild ground squirrels during the estrous period, early pregnancy and non-breeding period. In the estrous period and early pregnancy, NGF and TrkA were immunolocalized in stromal cells, lumina] epithelial cells, glandular cells and smooth muscle cells whereas in the non-breeding period, both of them were detected only in luminal epithelial cells and glandular cells, but not in stromal cells or smooth muscle cells. Stronger immunostaining of NGF and TrkA was observed in lumina] epithelial cells and glandular cells in the estrous period and early pregnancy as compared to the non-breeding period. p75 was immunolocalized only in luminal epithelial and glandular cells during the estrous period, early pregnancy and non-breeding period. The intensity of the immunohistochemical signals for p75 did not vary significantly in the estrous period, early pregnancy and non-breeding period. The mean mRNA levels of NGF and TrkA and p75 were significantly higher in the estrous period and early pregnancy as compared to the non-breeding period. Besides, plasma estradiol-17 beta and progesterone concentrations were higher in the estrous period and early pregnancy than in the non-breeding period, suggesting that the expression patterns of NGF and TrkA are correlated with changes in plasma estradiol-17 beta and progesterone concentrations. These results indicate that NGF and its receptor TrkA may be involved in the regulation of seasonal changes in the uterine functions of wild female ground squirrels. (C) 2011 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: IRT0607
项目资助者: Program for Changjiang Scholars and Innovative Research Team in Universities from China
WOS记录号: WOS:000301022000007
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52738
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Beijing 100083, Peoples R China
2.Univ Ottawa, Dept Biol, Ottawa, ON K1N 6N5, Canada
3.Beijing Forestry Univ, Coll Biol Sci & Technol, Physiol Anim Lab, Beijing 100083, Peoples R China
4.Karolinska Inst, Dept Biosci & Nutr, S-17177 Stockholm, Sweden
5.Tokyo Univ Agr & Technol, Fac Agr, Dept Vet Med, Vet Physiol Lab, Fuchu, Tokyo 1838509, Japan

Recommended Citation:
Li, Ben,Sheng, Xia,Song, Moshi,et al. Expression of nerve growth factor and its receptors TrkA and p75 in the uterus of wild female ground squirrel (Citellus dauricus Brandt)[J]. GENERAL AND COMPARATIVE ENDOCRINOLOGY,2012,176(1):62-69.
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