北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 天然药物学系  > 期刊论文
学科主题: 药学
题名:
Biotransformation products of phellopterin by rat liver microsomes and the inhibition on NO production in LPS-activated RAW264.7 cells
作者: Zhao, Ai-Hong1; Yang, Xin-Bao2,3; Yang, Xiu-Wei1; Zhang, You-Bo1; Xu, Wei1; Liu, Jian-Xun2,3
关键词: phellopterin ; byakangelicin ; coumarin ; liver microsomes ; biotransformation ; nitric oxide
刊名: JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
发表日期: 2012
DOI: 10.1080/10286020.2012.729506
卷: 14, 期:10, 页:956-965
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: ANGELICA-DAHURICA ; IN-VITRO ; FURANOCOUMARINS ; COUMARINS ; ROOTS
英文摘要:

Four new coumarins (2′,3′-dihydroxyphellopterin, E-5-methoxytrichoclin acetate, Z-5-methoxytrichoclin acetate, and E-5-methoxytrichoclin) and three known coumarins (byakangelicol, byakangelicin, and Z-5-methoxytrichoclin) were produced by liver microsomes from rats pre-treated with sodium phenobarbital. The chemical structures were elucidated on the basis of their spectroscopic data. The inhibitory activities of nitric oxide (NO) production in lipopolysaccharide-activated macrophage-like cell line RAW264.7 were tested. The main biotransformation product, byakangelicin, showed inhibitory activities of NO production with the IC50 value of 217.83 mu M, whereas the parent compound phellopterin showed cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 mu M.

语种: 英语
所属项目编号: 2012BAI29B02 ; 2011BAI07B08 ; 2006BAI 06A01-02
项目资助者: National Key Technology R&amp ; D Program of China
WOS记录号: WOS:000309991700004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52740
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Dept Nat Med, Sch Pharmaceut Sci,Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Beijing 100029, Peoples R China
3.China Acad Chinese Med Sci, Xiyuan Hosp, Res Ctr, Beijing 100091, Peoples R China

Recommended Citation:
Zhao, Ai-Hong,Yang, Xin-Bao,Yang, Xiu-Wei,et al. Biotransformation products of phellopterin by rat liver microsomes and the inhibition on NO production in LPS-activated RAW264.7 cells[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2012,14(10):956-965.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhao, Ai-Hong]'s Articles
[Yang, Xin-Bao]'s Articles
[Yang, Xiu-Wei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhao, Ai-Hong]‘s Articles
[Yang, Xin-Bao]‘s Articles
[Yang, Xiu-Wei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace