IR@PKUHSC  > 北京大学药学院  > 天然药物学系
学科主题药学
Biotransformation products of phellopterin by rat liver microsomes and the inhibition on NO production in LPS-activated RAW264.7 cells
Zhao, Ai-Hong1; Yang, Xin-Bao2,3; Yang, Xiu-Wei1; Zhang, You-Bo1; Xu, Wei1; Liu, Jian-Xun2,3
关键词Phellopterin Byakangelicin Coumarin Liver Microsomes Biotransformation Nitric Oxide
刊名JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
2012
DOI10.1080/10286020.2012.729506
14期:10页:956-965
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
资助者National Key Technology R&amp ; D Program of China ; National Key Technology R&amp ; D Program of China
研究领域[WOS]Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]ANGELICA-DAHURICA ; IN-VITRO ; FURANOCOUMARINS ; COUMARINS ; ROOTS
英文摘要

Four new coumarins (2′,3′-dihydroxyphellopterin, E-5-methoxytrichoclin acetate, Z-5-methoxytrichoclin acetate, and E-5-methoxytrichoclin) and three known coumarins (byakangelicol, byakangelicin, and Z-5-methoxytrichoclin) were produced by liver microsomes from rats pre-treated with sodium phenobarbital. The chemical structures were elucidated on the basis of their spectroscopic data. The inhibitory activities of nitric oxide (NO) production in lipopolysaccharide-activated macrophage-like cell line RAW264.7 were tested. The main biotransformation product, byakangelicin, showed inhibitory activities of NO production with the IC50 value of 217.83 mu M, whereas the parent compound phellopterin showed cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 mu M.

语种英语
所属项目编号2012BAI29B02 ; 2011BAI07B08 ; 2006BAI 06A01-02
资助者National Key Technology R&amp ; D Program of China ; National Key Technology R&amp ; D Program of China
WOS记录号WOS:000309991700004
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52740
专题北京大学药学院_天然药物学系
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Dept Nat Med, Sch Pharmaceut Sci,Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Beijing 100029, Peoples R China
3.China Acad Chinese Med Sci, Xiyuan Hosp, Res Ctr, Beijing 100091, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Ai-Hong,Yang, Xin-Bao,Yang, Xiu-Wei,et al. Biotransformation products of phellopterin by rat liver microsomes and the inhibition on NO production in LPS-activated RAW264.7 cells[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2012,14(10):956-965.
APA Zhao, Ai-Hong,Yang, Xin-Bao,Yang, Xiu-Wei,Zhang, You-Bo,Xu, Wei,&Liu, Jian-Xun.(2012).Biotransformation products of phellopterin by rat liver microsomes and the inhibition on NO production in LPS-activated RAW264.7 cells.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,14(10),956-965.
MLA Zhao, Ai-Hong,et al."Biotransformation products of phellopterin by rat liver microsomes and the inhibition on NO production in LPS-activated RAW264.7 cells".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 14.10(2012):956-965.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhao, Ai-Hong]的文章
[Yang, Xin-Bao]的文章
[Yang, Xiu-Wei]的文章
百度学术
百度学术中相似的文章
[Zhao, Ai-Hong]的文章
[Yang, Xin-Bao]的文章
[Yang, Xiu-Wei]的文章
必应学术
必应学术中相似的文章
[Zhao, Ai-Hong]的文章
[Yang, Xin-Bao]的文章
[Yang, Xiu-Wei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。