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学科主题基础医学
Effects of cocaine place conditioning, chronic escalating-dose "binge" pattern cocaine administration and acute withdrawal on orexin/hypocretin and preprodynorphin gene expressions in lateral hypothalamus of Fischer and Sprague-Dawley rats
Zhou, Y.1; Cui, C. -L.2,3; Schlussman, S. D.1; Choi, J. C.1; Ho, A.1; Han, J. -S.2,3; Kreek, M. J.1,3
关键词Conditioned Place Preference Mrna Naloxone Strain Difference
刊名NEUROSCIENCE
2008-06-02
DOI10.1016/j.neuroscience.2008.03.023
153期:4页:1225-1234
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]MESSENGER-RNA LEVELS ; MU-OPIOID RECEPTOR ; BEHAVIORAL SENSITIZATION ; DRUG-DEPENDENCE ; EXTENDED-ACCESS ; OREXIN NEURONS ; INDUCED REINSTATEMENT ; LOCOMOTOR-ACTIVITY ; REWARD PATHWAYS ; INBRED RATS
英文摘要

Recent evidence suggests an important role for hypothalamic orexins/hypocretins in modulation of drug reward and addiction-like behaviors in rodents. Our recent study has shown that the aversive state of arousal during acute morphine withdrawal is associated with increased orexin gene expression in lateral hypothalamus (LH) of Fischer 344 (F344) inbred rats, with no change in the expression of preprodynorphin (ppDyn), a gene co-expressed with LH orexin. Therefore, we determined whether orexin and ppDyn mRNA levels in LH or medial hypothalamus (including perifomical and dorsomedial areas) of F344 or Sprague-Dawley (SD) outbred rats, are altered following: 1) cocaine (10 mg/kg, i.p.) conditioned place preference (CPP); 2) chronic (14 days) cocaine exposure using both "binge" pattern administration in steady-dose (45 mg/kg/day) and escalating-dose (45-90 mg/kg/day) regimens; and 3) acute (1 day) and chronic (14 days) withdrawal from cocaine with opioid receptor antagonist naloxone treatment (1 mg/kg). We found that orexin mRNA levels were decreased after cocaine place conditioning in the LH of SD rats. A decreased LH orexin mRNA level was also observed after chronic escalating-dose cocaine (but not CPP pattern regimen without conditioning, or steady-dose regimen) in both strains. In F344 rats only, acute withdrawal from chronic escalating-dose cocaine administration resulted in increases in both LH orexin and ppDyn mRNA levels, which were unaltered by naloxone or after chronic withdrawal. Our results suggest that (1) alteration of LH orexin gene expression is region-specific after cocaine place conditioning in SD rats and dose-dependent after chronic exposure in both strains; and (2) increased LH orexin and ppDyn gene expressions in F344 rats may contribute to negative affective states in cocaine withdrawal. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000256742200031
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被引频次:48[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52744
专题北京大学基础医学院_神经生物学系
作者单位1.Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10065 USA
2.Harvard Univ, Sch Med, McLean Hosp, Bioorgan & Nat Prod Lab, Belmont, MA 02478 USA
3.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
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GB/T 7714
Zhou, Y.,Cui, C. -L.,Schlussman, S. D.,et al. Effects of cocaine place conditioning, chronic escalating-dose "binge" pattern cocaine administration and acute withdrawal on orexin/hypocretin and preprodynorphin gene expressions in lateral hypothalamus of Fischer and Sprague-Dawley rats[J]. NEUROSCIENCE,2008,153(4):1225-1234.
APA Zhou, Y..,Cui, C. -L..,Schlussman, S. D..,Choi, J. C..,Ho, A..,...&Kreek, M. J..(2008).Effects of cocaine place conditioning, chronic escalating-dose "binge" pattern cocaine administration and acute withdrawal on orexin/hypocretin and preprodynorphin gene expressions in lateral hypothalamus of Fischer and Sprague-Dawley rats.NEUROSCIENCE,153(4),1225-1234.
MLA Zhou, Y.,et al."Effects of cocaine place conditioning, chronic escalating-dose "binge" pattern cocaine administration and acute withdrawal on orexin/hypocretin and preprodynorphin gene expressions in lateral hypothalamus of Fischer and Sprague-Dawley rats".NEUROSCIENCE 153.4(2008):1225-1234.
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