北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 神经生物学系  > 期刊论文
学科主题: 基础医学
题名:
Effects of cocaine place conditioning, chronic escalating-dose "binge" pattern cocaine administration and acute withdrawal on orexin/hypocretin and preprodynorphin gene expressions in lateral hypothalamus of Fischer and Sprague-Dawley rats
作者: Zhou, Y.1; Cui, C. -L.2,3; Schlussman, S. D.1; Choi, J. C.1; Ho, A.1; Han, J. -S.2,3; Kreek, M. J.1,3
关键词: conditioned place preference ; mRNA ; naloxone ; strain difference
刊名: NEUROSCIENCE
发表日期: 2008-06-02
DOI: 10.1016/j.neuroscience.2008.03.023
卷: 153, 期:4, 页:1225-1234
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: MESSENGER-RNA LEVELS ; MU-OPIOID RECEPTOR ; BEHAVIORAL SENSITIZATION ; DRUG-DEPENDENCE ; EXTENDED-ACCESS ; OREXIN NEURONS ; INDUCED REINSTATEMENT ; LOCOMOTOR-ACTIVITY ; REWARD PATHWAYS ; INBRED RATS
英文摘要:

Recent evidence suggests an important role for hypothalamic orexins/hypocretins in modulation of drug reward and addiction-like behaviors in rodents. Our recent study has shown that the aversive state of arousal during acute morphine withdrawal is associated with increased orexin gene expression in lateral hypothalamus (LH) of Fischer 344 (F344) inbred rats, with no change in the expression of preprodynorphin (ppDyn), a gene co-expressed with LH orexin. Therefore, we determined whether orexin and ppDyn mRNA levels in LH or medial hypothalamus (including perifomical and dorsomedial areas) of F344 or Sprague-Dawley (SD) outbred rats, are altered following: 1) cocaine (10 mg/kg, i.p.) conditioned place preference (CPP); 2) chronic (14 days) cocaine exposure using both "binge" pattern administration in steady-dose (45 mg/kg/day) and escalating-dose (45-90 mg/kg/day) regimens; and 3) acute (1 day) and chronic (14 days) withdrawal from cocaine with opioid receptor antagonist naloxone treatment (1 mg/kg). We found that orexin mRNA levels were decreased after cocaine place conditioning in the LH of SD rats. A decreased LH orexin mRNA level was also observed after chronic escalating-dose cocaine (but not CPP pattern regimen without conditioning, or steady-dose regimen) in both strains. In F344 rats only, acute withdrawal from chronic escalating-dose cocaine administration resulted in increases in both LH orexin and ppDyn mRNA levels, which were unaltered by naloxone or after chronic withdrawal. Our results suggest that (1) alteration of LH orexin gene expression is region-specific after cocaine place conditioning in SD rats and dose-dependent after chronic exposure in both strains; and (2) increased LH orexin and ppDyn gene expressions in F344 rats may contribute to negative affective states in cocaine withdrawal. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000256742200031
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52744
Appears in Collections:基础医学院_神经生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Effects of cocaine place conditioning, chronic escalating-dose binge pattern cocaine administration and acute withdrawal on orexin hypocretin and preprodynorphin gene expressions in lateral.pdf(308KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10065 USA
2.Harvard Univ, Sch Med, McLean Hosp, Bioorgan & Nat Prod Lab, Belmont, MA 02478 USA
3.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Zhou, Y.,Cui, C. -L.,Schlussman, S. D.,et al. Effects of cocaine place conditioning, chronic escalating-dose "binge" pattern cocaine administration and acute withdrawal on orexin/hypocretin and preprodynorphin gene expressions in lateral hypothalamus of Fischer and Sprague-Dawley rats[J]. NEUROSCIENCE,2008,153(4):1225-1234.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhou, Y.]'s Articles
[Cui, C. -L.]'s Articles
[Schlussman, S. D.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhou, Y.]‘s Articles
[Cui, C. -L.]‘s Articles
[Schlussman, S. D.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace