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学科主题: 基础医学
题名:
Toll-like receptor 4-mediated signaling regulates IL-7-driven proliferation and differentiation of B-cell precursors
作者: Li, Qian1; Han, Dongmei1; Wang, Wei1; Liu, Xiaoqing2; Sun, Xiuyuan1; Zhang, Jun1; Li, Rong2; Zhang, Yu1
关键词: B-cell differentiation ; B lymphopoiesis ; IL-7 ; lipopolysaccharide ; Toll-like receptor 4
刊名: CELLULAR & MOLECULAR IMMUNOLOGY
发表日期: 2014-03-01
DOI: 10.1038/cmi.2013.55
卷: 11, 期:2, 页:132-140
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: BONE-MARROW ; CHAIN EXPRESSION ; LINEAGE-CELLS ; PRE-BCR ; IL-7 ; ACTIVATION ; MATURATION ; EXPANSION ; TLR4 ; RECOMBINATION
英文摘要:

Lipopolysaccharide (LPS) is known to be a potent activator of mature B cells by signaling through Toll-like receptor 4 (TLR4). Its impact on early B-cell development, however, is not well defined. When comparing to C3H/HeN mice, TLR4-mutant C3H/HeJ mice showed an increase in the number of pro-B and pre-B cells in the bone marrow. When cultured in the presence of IL-7, the proliferation of pro-B and large pre-B cells was significantly inhibited by LPS, possibly due to reduced IL-7 receptor-alpha (IL-7R alpha) expression. Meanwhile, the generation of IgM(+)/IgD(+) B cells was greatly enhanced in IL-7 cultures of pro-B and pre-B cells. Consistent with these results, treatment with LPS facilitated the progression of adoptively transferred B220(+)IgM(-)IgD(-) precursors into IgD(+) cells. Overall, these data suggest that LPS has a profound influence on early B-cell development, which may contribute to the deregulated B-cell development under physiological and pathological conditions such as bacterial infections.

语种: 英语
所属项目编号: 2011CB946100 ; 30830091 ; 30960357 ; B07001
项目资助者: National Basic Research Program of China ; National Natural Sciences Foundation of China ; 111 Project of China
WOS记录号: WOS:000332471400006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52747
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Key Lab Med Immunol, Dept Immunol,Minist Hlth, Beijing 100871, Peoples R China
2.Nanchang Univ, Inst Translat Med, Dept Microbiol, Fac Basic Med Sci, Nanchang, Peoples R China

Recommended Citation:
Li, Qian,Han, Dongmei,Wang, Wei,et al. Toll-like receptor 4-mediated signaling regulates IL-7-driven proliferation and differentiation of B-cell precursors[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2014,11(2):132-140.
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