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学科主题基础医学
Toll-like receptor 4-mediated signaling regulates IL-7-driven proliferation and differentiation of B-cell precursors
Li, Qian1; Han, Dongmei1; Wang, Wei1; Liu, Xiaoqing2; Sun, Xiuyuan1; Zhang, Jun1; Li, Rong2; Zhang, Yu1
关键词B-cell differentiation B lymphopoiesis IL-7 lipopolysaccharide Toll-like receptor 4
刊名CELLULAR & MOLECULAR IMMUNOLOGY
2014-03-01
DOI10.1038/cmi.2013.55
11期:2页:132-140
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]BONE-MARROW ; CHAIN EXPRESSION ; LINEAGE-CELLS ; PRE-BCR ; IL-7 ; ACTIVATION ; MATURATION ; EXPANSION ; TLR4 ; RECOMBINATION
英文摘要

Lipopolysaccharide (LPS) is known to be a potent activator of mature B cells by signaling through Toll-like receptor 4 (TLR4). Its impact on early B-cell development, however, is not well defined. When comparing to C3H/HeN mice, TLR4-mutant C3H/HeJ mice showed an increase in the number of pro-B and pre-B cells in the bone marrow. When cultured in the presence of IL-7, the proliferation of pro-B and large pre-B cells was significantly inhibited by LPS, possibly due to reduced IL-7 receptor-alpha (IL-7R alpha) expression. Meanwhile, the generation of IgM(+)/IgD(+) B cells was greatly enhanced in IL-7 cultures of pro-B and pre-B cells. Consistent with these results, treatment with LPS facilitated the progression of adoptively transferred B220(+)IgM(-)IgD(-) precursors into IgD(+) cells. Overall, these data suggest that LPS has a profound influence on early B-cell development, which may contribute to the deregulated B-cell development under physiological and pathological conditions such as bacterial infections.

语种英语
WOS记录号WOS:000332471400006
项目编号2011CB946100 ; 30830091 ; 30960357 ; B07001
资助机构National Basic Research Program of China ; National Natural Sciences Foundation of China ; 111 Project of China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52747
专题北京大学基础医学院_免疫学系
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Key Lab Med Immunol, Dept Immunol,Minist Hlth, Beijing 100871, Peoples R China
2.Nanchang Univ, Inst Translat Med, Dept Microbiol, Fac Basic Med Sci, Nanchang, Peoples R China
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GB/T 7714
Li, Qian,Han, Dongmei,Wang, Wei,et al. Toll-like receptor 4-mediated signaling regulates IL-7-driven proliferation and differentiation of B-cell precursors[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2014,11(2):132-140.
APA Li, Qian.,Han, Dongmei.,Wang, Wei.,Liu, Xiaoqing.,Sun, Xiuyuan.,...&Zhang, Yu.(2014).Toll-like receptor 4-mediated signaling regulates IL-7-driven proliferation and differentiation of B-cell precursors.CELLULAR & MOLECULAR IMMUNOLOGY,11(2),132-140.
MLA Li, Qian,et al."Toll-like receptor 4-mediated signaling regulates IL-7-driven proliferation and differentiation of B-cell precursors".CELLULAR & MOLECULAR IMMUNOLOGY 11.2(2014):132-140.
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