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学科主题临床医学
Magnetic/Upconversion Fluorescent NaGdF4:Yb,Er Nanoparticle-Based Dual-Modal Molecular Probes for Imaging Tiny Tumors in Vivo
Liu, Chunyan1; Gao, Zhenyu2; Zeng, Jianfeng1; Hou, Yi1; Fang, Fang3; Li, Yilin4; Qiao, Ruirui1; Shen, Lin4; Lei, Hao3; Yang, Wensheng2; Gao, Mingyuan1
关键词Magnetic/upconversion Fluorescent Nanoparticles Dual-modal Molecular Probes In Vivo Tumor imagIng Tiny Tumor Pharmacokinetics
刊名ACS NANO
2013-08-01
DOI10.1021/nn4030898
7期:8页:7227-7240
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science
关键词[WOS]UP-CONVERSION LUMINESCENCE ; MAGNETIC-RESONANCE DETECTION ; RAY COMPUTED-TOMOGRAPHY ; QUANTUM DOTS ; NAYF4 NANOPARTICLES ; OXIDE NANOPARTICLES ; CONTRAST AGENT ; NANOCRYSTALS ; SIZE ; NANOPHOSPHORS
英文摘要

Detection of early malignant tumors remains clinically difficult; developing ultrasensitive imaging agents is therefore highly demanded. Owing to the unusual magnetic and optical properties associated with f-electrons, rare-earth elements are very suitable for creating functional materials potentially useful for tumor imaging. Nanometer-sized particles offer such a platform with which versatile unique properties of the rare-earth elements can be Integrated. Yet the development of rare-earth nanopartide-based tumor probes suitable for imaging tiny tumors In vivo remains difficult, which challenges not only the physical properties of the nanoparticles but also the rationality of the probe design. Here we report new approaches for size control synthesis of magnetic/upconversion fluorescent NaGdF4:Yb,Er nanocrystals and their applications for imaging tiny tumors in vivo. By independently varying F-:Ln(3+) and Na+:Ln(3+) ratios, the size and shape regulation mechanisms were investigated. By replacing the oleic acid ligand with PEG2000 bearing a maleimide group at one end and two phosphate groups at the other end, PEGylated NaGdF4:Yb,Er nanoparticles with optimized size and upconversion fluorescence were obtained. Accordingly, a dual-modality molecular tumor probe was prepared, as a proof of concept, by covalently attaching antitumor antibody to PEGylated NaGdF4:Yb,Er nanoparticles through a "click" reaction. Systematic investigations on tumor detections, through magnetic resonance imaging and upconversion fluorescence imaging, were carried out to image intraperitoneal tumors and subcutaneous tumors in vivo. Owing to the excellent properties of the molecular probes, tumors smaller than 2 mm was successfully imaged in vivo:In addition, pharmacokinetic studies on differently sized particles were performed to disclose the particle size dependent biodistributions and elimination pathways.

语种英语
WOS记录号WOS:000323810600088
项目编号2011CB935800 ; 21203211 ; 81090271 ; 21003135 ; 21021003 ; KJCX2-YW-M15
资助机构National Basic Research Program of China ; NSFC ; CAS
引用统计
被引频次:201[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52748
专题北京大学临床肿瘤学院_胃肠肿瘤中心
北京大学临床肿瘤学院_消化肿瘤内科
作者单位1.Jilin Univ, Coll Chem, Changchun 130012, Peoples R China
2.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China
4.Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Gastrointestinal Oncol, Sch Oncol,Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
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Liu, Chunyan,Gao, Zhenyu,Zeng, Jianfeng,et al. Magnetic/Upconversion Fluorescent NaGdF4:Yb,Er Nanoparticle-Based Dual-Modal Molecular Probes for Imaging Tiny Tumors in Vivo[J]. ACS NANO,2013,7(8):7227-7240.
APA Liu, Chunyan.,Gao, Zhenyu.,Zeng, Jianfeng.,Hou, Yi.,Fang, Fang.,...&Gao, Mingyuan.(2013).Magnetic/Upconversion Fluorescent NaGdF4:Yb,Er Nanoparticle-Based Dual-Modal Molecular Probes for Imaging Tiny Tumors in Vivo.ACS NANO,7(8),7227-7240.
MLA Liu, Chunyan,et al."Magnetic/Upconversion Fluorescent NaGdF4:Yb,Er Nanoparticle-Based Dual-Modal Molecular Probes for Imaging Tiny Tumors in Vivo".ACS NANO 7.8(2013):7227-7240.
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