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IR@PKUHSC  > 北京大学临床肿瘤学院  > 胃肠肿瘤中心  > 期刊论文
学科主题: 临床医学
题名:
Magnetic/Upconversion Fluorescent NaGdF4:Yb,Er Nanoparticle-Based Dual-Modal Molecular Probes for Imaging Tiny Tumors in Vivo
作者: Liu, Chunyan1; Gao, Zhenyu2; Zeng, Jianfeng1; Hou, Yi1; Fang, Fang3; Li, Yilin4; Qiao, Ruirui1; Shen, Lin4; Lei, Hao3; Yang, Wensheng2; Gao, Mingyuan1
关键词: magnetic/upconversion fluorescent nanoparticles ; dual-modal molecular probes ; in vivo tumor imaging ; tiny tumor ; pharmacokinetics
刊名: ACS NANO
发表日期: 2013-08-01
DOI: 10.1021/nn4030898
卷: 7, 期:8, 页:7227-7240
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science
关键词[WOS]: UP-CONVERSION LUMINESCENCE ; MAGNETIC-RESONANCE DETECTION ; RAY COMPUTED-TOMOGRAPHY ; QUANTUM DOTS ; NAYF4 NANOPARTICLES ; OXIDE NANOPARTICLES ; CONTRAST AGENT ; NANOCRYSTALS ; SIZE ; NANOPHOSPHORS
英文摘要:

Detection of early malignant tumors remains clinically difficult; developing ultrasensitive imaging agents is therefore highly demanded. Owing to the unusual magnetic and optical properties associated with f-electrons, rare-earth elements are very suitable for creating functional materials potentially useful for tumor imaging. Nanometer-sized particles offer such a platform with which versatile unique properties of the rare-earth elements can be Integrated. Yet the development of rare-earth nanopartide-based tumor probes suitable for imaging tiny tumors In vivo remains difficult, which challenges not only the physical properties of the nanoparticles but also the rationality of the probe design. Here we report new approaches for size control synthesis of magnetic/upconversion fluorescent NaGdF4:Yb,Er nanocrystals and their applications for imaging tiny tumors in vivo. By independently varying F-:Ln(3+) and Na+:Ln(3+) ratios, the size and shape regulation mechanisms were investigated. By replacing the oleic acid ligand with PEG2000 bearing a maleimide group at one end and two phosphate groups at the other end, PEGylated NaGdF4:Yb,Er nanoparticles with optimized size and upconversion fluorescence were obtained. Accordingly, a dual-modality molecular tumor probe was prepared, as a proof of concept, by covalently attaching antitumor antibody to PEGylated NaGdF4:Yb,Er nanoparticles through a "click" reaction. Systematic investigations on tumor detections, through magnetic resonance imaging and upconversion fluorescence imaging, were carried out to image intraperitoneal tumors and subcutaneous tumors in vivo. Owing to the excellent properties of the molecular probes, tumors smaller than 2 mm was successfully imaged in vivo:In addition, pharmacokinetic studies on differently sized particles were performed to disclose the particle size dependent biodistributions and elimination pathways.

语种: 英语
所属项目编号: 2011CB935800 ; 21203211 ; 81090271 ; 21003135 ; 21021003 ; KJCX2-YW-M15
项目资助者: National Basic Research Program of China ; NSFC ; CAS
WOS记录号: WOS:000323810600088
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52748
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

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作者单位: 1.Jilin Univ, Coll Chem, Changchun 130012, Peoples R China
2.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China
4.Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Gastrointestinal Oncol, Sch Oncol,Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China

Recommended Citation:
Liu, Chunyan,Gao, Zhenyu,Zeng, Jianfeng,et al. Magnetic/Upconversion Fluorescent NaGdF4:Yb,Er Nanoparticle-Based Dual-Modal Molecular Probes for Imaging Tiny Tumors in Vivo[J]. ACS NANO,2013,7(8):7227-7240.
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