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The International Agency for Research on Cancer (IARC) evaluation of the carcinogenicity of outdoor air pollution: focus on China
Loomis, Dana1; Huang, Wei2; Chen, Guosheng3
关键词Air Pollution Particulate Matter Lung Cancer China
刊名CHINESE JOURNAL OF CANCER
2014-04-01
DOI10.5732/cjc.014.10028
33期:4页:189-196
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]LUNG-CANCER ; EXPOSURE ; CITY ; GENOTOXICITY ; MORTALITY ; HEALTH ; DAMAGE ; MICE
英文摘要

The International Agency for Research on Cancer ( IARC) has classified outdoor air pollution and the particulate matter (PM) in outdoor air pollution as carcinogenic to humans, as based on sufficient evidence of carcinogenicity in humans and experimental animals and strong support by mechanistic studies. The data with important contributions to the evaluation are reviewed, highlighting the data with particular relevance to China, and implications of the evaluation with respect to China are discussed. The air pollution levels in Chinese cities are among the highest observed in the world today and frequently exceed health-based national and international guidelines. Data from high-quality epidemiologic studies in Asia, Europe, and North America consistently show positive associations between lung cancer and PM exposure and other indicators of air pollution, which persist after adjustment for important lung cancer risk factors, such as tobacco smoking. Epidemiologic data from China are limited but nevertheless indicate an increased risk of lung cancer associated with several air pollutants. Excess cancer risk is also observed in experimental animals exposed to polluted outdoor air or extracted PM. The exposure of several species to outdoor air pollution is associated with markers of genetic damage that have been linked to increased cancer risk in humans. Numerous studies from China, especially genetic biomarker studies in exposed populations, support that the polluted air in China is genotoxic and carcinogenic to humans. The evaluation by IARC indicates both the need for further research into the cancer risks associated with exposure to air pollution in China and the urgent need to act to reduce exposure to the population.

语种英语
WOS记录号WOS:000339652300003
引用统计
被引频次:62[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52750
专题北京大学公共卫生学院
作者单位1.Int Agcy Res Canc, F-69008 Lyon, France
2.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Beijing 100191, Peoples R China
3.Hlth Canada, Healthy Environm & Consumer Safety Branch, Existing Subst Risk Assessment Bur, Safe Environm Directorate, Ottawa, ON K1A 0K9, Canada
推荐引用方式
GB/T 7714
Loomis, Dana,Huang, Wei,Chen, Guosheng. The International Agency for Research on Cancer (IARC) evaluation of the carcinogenicity of outdoor air pollution: focus on China[J]. CHINESE JOURNAL OF CANCER,2014,33(4):189-196.
APA Loomis, Dana,Huang, Wei,&Chen, Guosheng.(2014).The International Agency for Research on Cancer (IARC) evaluation of the carcinogenicity of outdoor air pollution: focus on China.CHINESE JOURNAL OF CANCER,33(4),189-196.
MLA Loomis, Dana,et al."The International Agency for Research on Cancer (IARC) evaluation of the carcinogenicity of outdoor air pollution: focus on China".CHINESE JOURNAL OF CANCER 33.4(2014):189-196.
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