IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Simultaneous detection of residues of beta-adrenergic receptor blockers and sedatives in animal tissues by high-performance liquid chromatography/tandem mass spectrometry
Zhang, Jing1; Shao, Bing1,2; Yin, Jie3; Wu, Yongning1; Duan, Hejun1
关键词Beta-blocker Sedative Lc-ms/ms Animal Tissues
刊名JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2009-07-01
DOI10.1016/j.jchromb.2009.05.025
877期:20-21页:1915-1922
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
资助者National Key Technology RD Program ; Scientific Olympics in the Beijing Science &amp ; Technology Special Program ; National Key Technology RD Program ; Scientific Olympics in the Beijing Science &amp ; Technology Special Program
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]ATMOSPHERIC-PRESSURE PHOTOIONIZATION ; PIG-TISSUES ; CHEMICAL-IONIZATION ; TRANQUILIZERS ; CARAZOLOL ; AZAPERONE ; HPLC ; CONFIRMATION ; STRATEGIES ; XYLAZINE
英文摘要

A method using high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) was developed to screen and confirm residues of multi-class veterinary drugs in animal tissues (porcine kidney, liver, muscle; bovine muscle). Thirty target drugs (19 beta-blockers, 11 sedatives) were determined simultaneously in a single run. Homogenized tissue samples were extracted with acetonitrile and purified using a NH(2) solid-phase extraction cartridge. An Acquity UPLC (TM) BEH C18 column was used to separate the analytes. followed by tandem mass spectrometry using an electrospray ionization source in positive mode. Recovery studies were done at three fortification levels. Overall average recoveries in pig muscle, kidney, and liver fortified at three levels from 76.4% to 118.6% based on matrix-fortified calibration with coefficients of variation from 2.2% to 19.9% (n = 6). The limit of quantification of these compounds in different matrices was 0.5-2.0 mu g/kg. This method was successfully applied in screening and confirming target drugs in >200 samples. (C) 2009 Elsevier B.V. All rights reserved.

语种英语
所属项目编号2006BAK02A27 ; Z07001000560708
资助者National Key Technology RD Program ; Scientific Olympics in the Beijing Science &amp ; Technology Special Program ; National Key Technology RD Program ; Scientific Olympics in the Beijing Science &amp ; Technology Special Program
WOS记录号WOS:000267453800018
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52756
专题北京大学公共卫生学院
作者单位1.Beijing Ctr Dis Control & Prevent, Cent Lab, Beijing 100013, Peoples R China
2.Capital Med Univ, Sch Publ Hlth & Family Med, Beijing 100089, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Food Hyg & Nutr, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Jing,Shao, Bing,Yin, Jie,et al. Simultaneous detection of residues of beta-adrenergic receptor blockers and sedatives in animal tissues by high-performance liquid chromatography/tandem mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2009,877(20-21):1915-1922.
APA Zhang, Jing,Shao, Bing,Yin, Jie,Wu, Yongning,&Duan, Hejun.(2009).Simultaneous detection of residues of beta-adrenergic receptor blockers and sedatives in animal tissues by high-performance liquid chromatography/tandem mass spectrometry.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,877(20-21),1915-1922.
MLA Zhang, Jing,et al."Simultaneous detection of residues of beta-adrenergic receptor blockers and sedatives in animal tissues by high-performance liquid chromatography/tandem mass spectrometry".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 877.20-21(2009):1915-1922.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Jing]的文章
[Shao, Bing]的文章
[Yin, Jie]的文章
百度学术
百度学术中相似的文章
[Zhang, Jing]的文章
[Shao, Bing]的文章
[Yin, Jie]的文章
必应学术
必应学术中相似的文章
[Zhang, Jing]的文章
[Shao, Bing]的文章
[Yin, Jie]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。