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Simultaneous detection of residues of beta-adrenergic receptor blockers and sedatives in animal tissues by high-performance liquid chromatography/tandem mass spectrometry
Zhang, Jing1; Shao, Bing1,2; Yin, Jie3; Wu, Yongning1; Duan, Hejun1
关键词Beta-blocker Sedative Lc-ms/ms Animal Tissues
刊名JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2009-07-01
DOI10.1016/j.jchromb.2009.05.025
877期:20-21页:1915-1922
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
资助者National Key Technology RD Program ; Scientific Olympics in the Beijing Science &amp ; Technology Special Program ; National Key Technology RD Program ; Scientific Olympics in the Beijing Science &amp ; Technology Special Program
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]ATMOSPHERIC-PRESSURE PHOTOIONIZATION ; PIG-TISSUES ; CHEMICAL-IONIZATION ; TRANQUILIZERS ; CARAZOLOL ; AZAPERONE ; HPLC ; CONFIRMATION ; STRATEGIES ; XYLAZINE
英文摘要

A method using high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) was developed to screen and confirm residues of multi-class veterinary drugs in animal tissues (porcine kidney, liver, muscle; bovine muscle). Thirty target drugs (19 beta-blockers, 11 sedatives) were determined simultaneously in a single run. Homogenized tissue samples were extracted with acetonitrile and purified using a NH(2) solid-phase extraction cartridge. An Acquity UPLC (TM) BEH C18 column was used to separate the analytes. followed by tandem mass spectrometry using an electrospray ionization source in positive mode. Recovery studies were done at three fortification levels. Overall average recoveries in pig muscle, kidney, and liver fortified at three levels from 76.4% to 118.6% based on matrix-fortified calibration with coefficients of variation from 2.2% to 19.9% (n = 6). The limit of quantification of these compounds in different matrices was 0.5-2.0 mu g/kg. This method was successfully applied in screening and confirming target drugs in >200 samples. (C) 2009 Elsevier B.V. All rights reserved.

语种英语
所属项目编号2006BAK02A27 ; Z07001000560708
资助者National Key Technology RD Program ; Scientific Olympics in the Beijing Science &amp ; Technology Special Program ; National Key Technology RD Program ; Scientific Olympics in the Beijing Science &amp ; Technology Special Program
WOS记录号WOS:000267453800018
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52756
Collection北京大学公共卫生学院
作者单位1.Beijing Ctr Dis Control & Prevent, Cent Lab, Beijing 100013, Peoples R China
2.Capital Med Univ, Sch Publ Hlth & Family Med, Beijing 100089, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Food Hyg & Nutr, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Jing,Shao, Bing,Yin, Jie,et al. Simultaneous detection of residues of beta-adrenergic receptor blockers and sedatives in animal tissues by high-performance liquid chromatography/tandem mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2009,877(20-21):1915-1922.
APA Zhang, Jing,Shao, Bing,Yin, Jie,Wu, Yongning,&Duan, Hejun.(2009).Simultaneous detection of residues of beta-adrenergic receptor blockers and sedatives in animal tissues by high-performance liquid chromatography/tandem mass spectrometry.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,877(20-21),1915-1922.
MLA Zhang, Jing,et al."Simultaneous detection of residues of beta-adrenergic receptor blockers and sedatives in animal tissues by high-performance liquid chromatography/tandem mass spectrometry".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 877.20-21(2009):1915-1922.
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