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学科主题: 口腔医学
题名:
Thioredoxin 1 mediates TGF-beta-induced epithelial-mesenchymal transition in salivary adenoid cystic carcinoma
作者: Jiang, Yang1; Feng, Xin2; Zheng, Lei1; Li, Sheng-Lin3; Ge, Xi-Yuan3; Zhang, Jian-Guo1
关键词: thioredoxin 1 ; epithelial-mesenchymal transition ; metastasis ; TGF-beta ; salivary adenoid cystic carcinoma
刊名: ONCOTARGET
发表日期: 2015-09-22
卷: 6, 期:28, 页:25506-25519
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Cell Biology
研究领域[WOS]: Oncology ; Cell Biology
关键词[WOS]: TRANSCRIPTION FACTOR SNAIL ; LEUKEMIA-DERIVED FACTOR ; GROWTH-FACTOR-BETA ; REDOX FACTOR-I ; SIGNALING PATHWAY ; GENE-EXPRESSION ; POOR-PROGNOSIS ; CELL INVASION ; CANCER ; METASTASIS
英文摘要:

Epithelial-mesenchymal transition (EMT) plays an important role in the invasion and metastasis of salivary adenoid cystic carcinoma (SACC) which is characterized by wide local infiltration, perineural spread, a propensity to local recurrence and late distant metastasis. Our recent studies have disclosed that TGF-beta is a crucial factor for EMT in metastatic SACC. In this study, we further uncovered small redox protein thioredoxin 1 (TXN) as a critical mediator of TGF-beta induced EMT. Immunohistochemistry analysis revealed significantly higher expressions of TXN, thioredoxin reductase 1 (TXNRD1) and N-cadherin, and lower expression of E-cadherin in human metastatic SACC compared to non-metastatic SACC tissues. Consistently, cultured SACC cells with stable TXN overexpression had decreased E-cadherin and increased N-cadherin as well as Snail and Slug expressions. The enhanced migration and invasion potential of these cells was abrogated by Akt or TXNRD1 inhibitors. Expression of N-cadherin and Akt p-Akt decreased, whereas E-cadherin expression increased in a BBSKE (TXNRD1 inhibitor)-dose-dependent manner. In a xenograft mouse model, TXN overexpression facilitated the metastatic potential of SACC-83 cells to the lung. Our results indicate that TXN plays a key role in SACC invasion and metastasis through the modulation of TGF-beta-Akt/ GSK-3 beta on EMT. TXN could be a potential therapeutic target for SACC.

语种: 英语
所属项目编号: 81272966 ; 81272967
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000363160100077
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52763
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Wake Forest Sch Med, Dept Otolaryngol, Winston Salem, NC 27157 USA
3.Peking Univ Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China

Recommended Citation:
Jiang, Yang,Feng, Xin,Zheng, Lei,et al. Thioredoxin 1 mediates TGF-beta-induced epithelial-mesenchymal transition in salivary adenoid cystic carcinoma[J]. ONCOTARGET,2015,6(28):25506-25519.
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