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学科主题: 临床医学
题名:
p53 polymorphism and p21(WAF1/CIP1) haplotype in the intestinal gastric cancer and the precancerous lesions
作者: Xi, YG1; Ding, KY1; Su, XL1; Chen, DF1; You, WC1; Shen, Y1; Ke, Y1
刊名: CARCINOGENESIS
发表日期: 2004-11-01
DOI: 10.1093/carcin/bgh229
卷: 25, 页:2201-2206
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: DEPENDENT KINASE INHIBITOR ; CODON 72 POLYMORPHISM ; LUNG-CANCER ; CERVICAL-CANCER ; BREAST-CANCER ; GENETIC SUSCEPTIBILITY ; WAF1/CIP1 GENE ; ARG ALLELE ; HIGH-RISK ; ASSOCIATION
英文摘要:

The development of intestinal gastric carcinoma involves several precancerous stages. The environmental factor plays an important role in gastric carcinogenesis, while the host′s genetic makeup may influence the susceptibility to cancer. In this study we investigated correlations of the p53 variations at codon 72 and p21(WAF1/CIP1) haplotype with the risk of intestinal gastric carcinoma. Forty-eight intestinal gastric carcinoma cases (GC), 96 chronic atrophic gastritis (CAG), 96 intestinal metaplasia (IM) and 96 dysplasia (DYS) controls were enrolled in this study. The p53 codon 72 proline allele carriers were found to be more susceptible to progress to GC than to IM (OR = 2.22, 95%CI = 1.05-4.70, P = 0.038). Patients carrying homozygous p21(WAF1/CIP1) haplotype A, which contains the serine at codon 31, the cytidine at the 16th base of the second intron, and the cytidine at the 70th base of the exon 3 were more prone to develop GC than to reach the IM or DYS stage (IM versus GC, OR = 3.35, 95%CI = 1.11-10.15; DYS versus GC, OR = 3.27, 95%CI = 1.09-9.80, P = 0.035). The combination of p53 codon 72 variation with the p21(WAF1/CIP1) haplotype further distinguished the risk of GC from IM precancerous lesion (OR = 9.31, 95% CI = 1.77-48.85, P = 0.08). These results suggest that p53 and/or p21(WAF1/CIP1) genotype may influence the progression during gastric tumorigenesis.

语种: 英语
WOS记录号: WOS:000225251200022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52768
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Inner Mongolia Med Coll, Hohhot, Peoples R China
2.Chinese Natl Human Genome Ctr, Beijing, Peoples R China
3.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Beijing, Peoples R China
4.Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100730, Peoples R China
5.Peking Union Med Coll, Beijing, Peoples R China
6.Peking Univ, Dept Cell Biol & Human Genet, Beijing 100871, Peoples R China

Recommended Citation:
Xi, YG,Ding, KY,Su, XL,et al. p53 polymorphism and p21(WAF1/CIP1) haplotype in the intestinal gastric cancer and the precancerous lesions[J]. CARCINOGENESIS,2004,25(11):2201-2206.
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