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学科主题: 药学
题名:
Directional modifications of resibufogenin by Mucor subtilissimus and Pseudomonas aeruginosa
作者: Zhan, JX1; Zhang, YX1; Liu, WH1; Guo, HZ1; Guo, D1
关键词: directional modifications ; resibufogenin ; hydroxylation ; Mucor subtilissimus ; dehydrogenation ; Pseudomonas aeruginosa
刊名: BIOCATALYSIS AND BIOTRANSFORMATION
发表日期: 2003-06-01
DOI: 10.1080/10242420310001597793
卷: 21, 期:3, 页:141-143
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
关键词[WOS]: BUFADIENOLIDES
英文摘要:

Directional modifications of resibufogenin 1 by Mucor subtilissimus and Pseudomonas aeruginosa were carried out. The substrate was hydroxylated at C-12 by M . subtilissimus AS 3.2454, from which a major product 12-hydroxyresibufogenin 2 was obtained. Then product 2 was dehydrogenated by P . aeruginosa AS 1.860, which resulted in a new compound 12beta-hydroxy-3-keto-resibufogenin 3.

语种: 英语
WOS记录号: WOS:000185244200007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52769
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.E China Univ Sci & Technol, Lab Bioreactor Engn, Shanghai 200237, Peoples R China

Recommended Citation:
Zhan, JX,Zhang, YX,Liu, WH,et al. Directional modifications of resibufogenin by Mucor subtilissimus and Pseudomonas aeruginosa[J]. BIOCATALYSIS AND BIOTRANSFORMATION,2003,21(3):141-143.
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