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An association study of HFE gene mutation with idiopathic male infertility in the Chinese Han population
Yu, Xiao-Ying1; Wang, Bin-Bin2,3; Xin, Zhong-Cheng4; Liu, Tao1; Ma, Ke1; Jiang, Jian1; Fang, Xiang1; Yu, Li-Hua1; Peng, Yi-Feng1; Ma, Xu2,3,5
关键词Gene Mutation Gonadotropic Hormone Hfe Male Infertility
刊名ASIAN JOURNAL OF ANDROLOGY
2012-07-01
DOI10.1038/aja.2012.1
14期:4页:599-603
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Andrology ; Urology & Nephrology
研究领域[WOS]Endocrinology & Metabolism ; Urology & Nephrology
关键词[WOS]CELL-SURFACE EXPRESSION ; HEREDITARY HEMOCHROMATOSIS ; IRON INTOXICATION ; OXIDATIVE DAMAGE ; TESTES ; C282Y ; H63D ; MEN ; BETA(2)-MICROGLOBULIN ; PROTEIN
英文摘要

Mutations in the haemochromatosis gene (HFE) influence iron status in the general population of Northern Europe, and excess iron is associated with the impairment of spermatogenesis. The aim of this study is to investigate the association between three mutations (C282Y, H63D and S65C) in the HFE gene with idiopathic male infertility in the Chinese Han population. Two groups of Chinese men were recruited: 444 infertile men(including 169 with idiopathic azoospermia) and 423 controls with proven fertility. The HFE gene was detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The experimental results demonstrated that no C282Y or S65C mutations were detected. Idiopathic male infertility was not significantly associated with heterozygous H63D mutation (odds ratio=0.801, 95% confidence interval=0.452-1.421, chi(2)=0.577, P=0.448). The H63D mutation frequency did not correlate significantly with the serum luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone (T) levels in infertile men (P=0.896, P=0.404 and P=0.05, respectively). Our data suggest that the HFE H63D mutation is not associated with idiopathic male reproductive dysfunction. Asian Journal of Andrology (2012) 14, 599-603; doi:10.1038/aja.2012.1; published online 16 April 2012

语种英语
WOS记录号WOS:000305998300019
项目编号2010CB945102 ; 30973197 ; 2008BAH24B05 ; 2006DKA21300
资助机构National Basic Research Program of China ; National Natural Science Foundation of China ; National Science &amp ; Technology Pillar Program of China ; National Infrastructure Program of Chinese Genetic Resources
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52776
专题北京大学第一临床医学院_男科中心
作者单位1.Yijishan Hosp, Wannan Med Coll, Inst Reprod Med, Wuhu 241001, Peoples R China
2.Natl Res Inst Family Planning, Beijing 100081, Peoples R China
3.Peking Union Med Coll, Beijing 100081, Peoples R China
4.Peking Univ First Hosp, Androl Ctr, Beijing 100034, Peoples R China
5.World Hlth Org Collaborating Ctr Res Human Reprod, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Yu, Xiao-Ying,Wang, Bin-Bin,Xin, Zhong-Cheng,et al. An association study of HFE gene mutation with idiopathic male infertility in the Chinese Han population[J]. ASIAN JOURNAL OF ANDROLOGY,2012,14(4):599-603.
APA Yu, Xiao-Ying.,Wang, Bin-Bin.,Xin, Zhong-Cheng.,Liu, Tao.,Ma, Ke.,...&Ma, Xu.(2012).An association study of HFE gene mutation with idiopathic male infertility in the Chinese Han population.ASIAN JOURNAL OF ANDROLOGY,14(4),599-603.
MLA Yu, Xiao-Ying,et al."An association study of HFE gene mutation with idiopathic male infertility in the Chinese Han population".ASIAN JOURNAL OF ANDROLOGY 14.4(2012):599-603.
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