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学科主题: 临床医学
题名:
An association study of HFE gene mutation with idiopathic male infertility in the Chinese Han population
作者: Yu, Xiao-Ying1; Wang, Bin-Bin2,3; Xin, Zhong-Cheng4; Liu, Tao1; Ma, Ke1; Jiang, Jian1; Fang, Xiang1; Yu, Li-Hua1; Peng, Yi-Feng1; Ma, Xu2,3,5
关键词: gene mutation ; gonadotropic hormone ; HFE ; male infertility
刊名: ASIAN JOURNAL OF ANDROLOGY
发表日期: 2012-07-01
DOI: 10.1038/aja.2012.1
卷: 14, 期:4, 页:599-603
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Andrology ; Urology & Nephrology
研究领域[WOS]: Endocrinology & Metabolism ; Urology & Nephrology
关键词[WOS]: CELL-SURFACE EXPRESSION ; HEREDITARY HEMOCHROMATOSIS ; IRON INTOXICATION ; OXIDATIVE DAMAGE ; TESTES ; C282Y ; H63D ; MEN ; BETA(2)-MICROGLOBULIN ; PROTEIN
英文摘要:

Mutations in the haemochromatosis gene (HFE) influence iron status in the general population of Northern Europe, and excess iron is associated with the impairment of spermatogenesis. The aim of this study is to investigate the association between three mutations (C282Y, H63D and S65C) in the HFE gene with idiopathic male infertility in the Chinese Han population. Two groups of Chinese men were recruited: 444 infertile men(including 169 with idiopathic azoospermia) and 423 controls with proven fertility. The HFE gene was detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The experimental results demonstrated that no C282Y or S65C mutations were detected. Idiopathic male infertility was not significantly associated with heterozygous H63D mutation (odds ratio=0.801, 95% confidence interval=0.452-1.421, chi(2)=0.577, P=0.448). The H63D mutation frequency did not correlate significantly with the serum luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone (T) levels in infertile men (P=0.896, P=0.404 and P=0.05, respectively). Our data suggest that the HFE H63D mutation is not associated with idiopathic male reproductive dysfunction. Asian Journal of Andrology (2012) 14, 599-603; doi:10.1038/aja.2012.1; published online 16 April 2012

语种: 英语
所属项目编号: 2010CB945102 ; 30973197 ; 2008BAH24B05 ; 2006DKA21300
项目资助者: National Basic Research Program of China ; National Natural Science Foundation of China ; National Science &amp ; Technology Pillar Program of China ; National Infrastructure Program of Chinese Genetic Resources
WOS记录号: WOS:000305998300019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52776
Appears in Collections:北京大学第一临床医学院_男科中心_期刊论文

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作者单位: 1.Yijishan Hosp, Wannan Med Coll, Inst Reprod Med, Wuhu 241001, Peoples R China
2.Natl Res Inst Family Planning, Beijing 100081, Peoples R China
3.Peking Union Med Coll, Beijing 100081, Peoples R China
4.Peking Univ First Hosp, Androl Ctr, Beijing 100034, Peoples R China
5.World Hlth Org Collaborating Ctr Res Human Reprod, Beijing 100081, Peoples R China

Recommended Citation:
Yu, Xiao-Ying,Wang, Bin-Bin,Xin, Zhong-Cheng,et al. An association study of HFE gene mutation with idiopathic male infertility in the Chinese Han population[J]. ASIAN JOURNAL OF ANDROLOGY,2012,14(4):599-603.
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