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Prospective memory tasks: a more sensitive method for screening cognitive impairment in ALS?
Ji, Ying1; Wei, Ling2; Chui, Dehua1,3; Wang, Kai2; Fan, Dongsheng1
刊名BMC NEUROLOGY
2012-11-21
DOI10.1186/1471-2377-12-142
12
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]AMYOTROPHIC-LATERAL-SCLEROSIS ; PREFRONTAL CORTEX AREA-10 ; INVOLVEMENT ; DISEASE ; METAANALYSIS ; DYSFUNCTION ; DIAGNOSIS ; CRITERIA ; BRAIN
英文摘要

Background: Cognitive change is prevalent in patients with amyotrophic lateral sclerosis (ALS), but still lack a widely accepted and sensitive screening method. In this study, we try to find a sensitive screening battery for detecting subtle cognitive deficits in patients with ALS.

Methods: Eighty consecutive ALS patients and 57 matched normal controls underwent the Mini-Mental Status Examination (MMSE), the verbal fluency test (VFT), the Stroop Color Word Interference Test (CWT), and the prospective memory (PM) tests, including event-based (EBPM) and time-based (TBPM).

Results: The patients did not differ from the controls in the MMSE, the VFT and the CWT. By contrast, statistically significant differences were found in the PM tests (EBPM: P=0.043; TBPM: P<0.001). More interestingly, TBPM was more sensitive than EBPM in the early-phase patients.

Conclusions: Prefrontal lobar dysfunction does exist among ALS patients and may spread from the medial to the lateral region. The PM tests seem more sensitive in ALS patients with frontotemporal dysfunction than are the classical cognitive measures.

语种英语
WOS记录号WOS:000314270700001
项目编号81030019 ; 30871359 ; 7082099 ; 7102161 ; 20100001110084 ; SF-2009-III-34
资助机构National Natural Sciences Foundation of China ; Beijing Natural Science Foundation ; Doctoral Fund of Chinese Ministry of Education ; Capital Medical Technology Development Foundation
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52777
专题北京大学第三临床医学院_神经内科
作者单位1.Peking Univ, Hosp 3, Dept Neurol, Beijing 100871, Peoples R China
2.Anhui Med Univ, Hosp 1, Dept Neurol, Hefei, Peoples R China
3.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Ji, Ying,Wei, Ling,Chui, Dehua,et al. Prospective memory tasks: a more sensitive method for screening cognitive impairment in ALS?[J]. BMC NEUROLOGY,2012,12.
APA Ji, Ying,Wei, Ling,Chui, Dehua,Wang, Kai,&Fan, Dongsheng.(2012).Prospective memory tasks: a more sensitive method for screening cognitive impairment in ALS?.BMC NEUROLOGY,12.
MLA Ji, Ying,et al."Prospective memory tasks: a more sensitive method for screening cognitive impairment in ALS?".BMC NEUROLOGY 12(2012).
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