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学科主题: 临床医学
题名:
Prospective memory tasks: a more sensitive method for screening cognitive impairment in ALS?
作者: Ji, Ying1; Wei, Ling2; Chui, Dehua1,3; Wang, Kai2; Fan, Dongsheng1
刊名: BMC NEUROLOGY
发表日期: 2012-11-21
DOI: 10.1186/1471-2377-12-142
卷: 12
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: AMYOTROPHIC-LATERAL-SCLEROSIS ; PREFRONTAL CORTEX AREA-10 ; INVOLVEMENT ; DISEASE ; METAANALYSIS ; DYSFUNCTION ; DIAGNOSIS ; CRITERIA ; BRAIN
英文摘要:

Background: Cognitive change is prevalent in patients with amyotrophic lateral sclerosis (ALS), but still lack a widely accepted and sensitive screening method. In this study, we try to find a sensitive screening battery for detecting subtle cognitive deficits in patients with ALS.

Methods: Eighty consecutive ALS patients and 57 matched normal controls underwent the Mini-Mental Status Examination (MMSE), the verbal fluency test (VFT), the Stroop Color Word Interference Test (CWT), and the prospective memory (PM) tests, including event-based (EBPM) and time-based (TBPM).

Results: The patients did not differ from the controls in the MMSE, the VFT and the CWT. By contrast, statistically significant differences were found in the PM tests (EBPM: P=0.043; TBPM: P<0.001). More interestingly, TBPM was more sensitive than EBPM in the early-phase patients.

Conclusions: Prefrontal lobar dysfunction does exist among ALS patients and may spread from the medial to the lateral region. The PM tests seem more sensitive in ALS patients with frontotemporal dysfunction than are the classical cognitive measures.

语种: 英语
所属项目编号: 81030019 ; 30871359 ; 7082099 ; 7102161 ; 20100001110084 ; SF-2009-III-34
项目资助者: National Natural Sciences Foundation of China ; Beijing Natural Science Foundation ; Doctoral Fund of Chinese Ministry of Education ; Capital Medical Technology Development Foundation
WOS记录号: WOS:000314270700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52777
Appears in Collections:北京大学第三临床医学院_神经内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Neurol, Beijing 100871, Peoples R China
2.Anhui Med Univ, Hosp 1, Dept Neurol, Hefei, Peoples R China
3.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China

Recommended Citation:
Ji, Ying,Wei, Ling,Chui, Dehua,et al. Prospective memory tasks: a more sensitive method for screening cognitive impairment in ALS?[J]. BMC NEUROLOGY,2012,12.
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