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学科主题: 临床医学
题名:
Distribution of Serotypes, Genotypes, and Resistance Determinants among Macrolide-Resistant Streptococcus pneumoniae Isolates
作者: Xu, Xiaoping1,2; Cai, Lin1,3; Xiao, Meng1,4; Kong, Fanrong1; Oftadeh, Shahin1; Zhou, Fei1; Gilbert, Gwendolyn L.1
刊名: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
发表日期: 2010-03-01
DOI: 10.1128/AAC.01268-09
卷: 54, 期:3, 页:1152-1159
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]: Microbiology ; Pharmacology & Pharmacy
关键词[WOS]: BLOT HYBRIDIZATION ASSAY ; EFFLUX GENE MEF(A) ; ERYTHROMYCIN RESISTANCE ; MOLECULAR EPIDEMIOLOGY ; MULTIPLEX PCR ; BETA-LACTAM ; ERM(B) ; TRANSPOSON ; ELEMENTS ; FLUOROQUINOLONE
英文摘要:

Macrolide resistance in Streptococcus pneumoniae has emerged as an important clinical problem worldwide over the past decade. The aim of this study was to analyze the phenotypes (serotype and antibiotic susceptibility), genotypes (multilocus sequence type [MLST] and antibiotic resistance gene/transposon profiles) among the 31% (102/328) of invasive isolates from children in New South Wales, Australia, in 2005 that were resistant to erythromycin. Three serotypes-19F (47 isolates [46%]), 14 (27 isolates [26%]), and 6B (12 isolates [12%])-accounted for 86 (84%) of these 102 isolates. Seventy four (73%) isolates had the macrolide-lincosamide-streptogramin B (MLS(B)) resistance phenotype and carried Tn916 transposons (most commonly Tn6002); of these, 73 (99%) contained the erythromycin ribosomal methylase gene [erm(B)], 34 (47%) also carried the macrolide efflux gene [mef(E)], and 41 (55%) belonged to serotype 19F. Of 28 (27%) isolates with the M phenotype, 22 (79%) carried mef(A), including 16 (57%) belonging to serotype 14, and only six (19%) carried Tn916 transposons. Most (84%) isolates which contained mef also contained one of the msr(A) homologues, mel or msr(D); 38 of 40 (95%) isolates with mef(E) (on mega) carried mel, and of 28 (39%) isolates with mef(A), 10 (39%) carried mel and another 11(39%) carried msr(D), on Tn1207.1. Two predominant macrolide-resistant S. pneumoniae clonal clusters (CCs) were identified in this population. CC-271 contained 44% of isolates, most of which belonged to serotype 19F, had the MLS(B) phenotype, were multidrug resistant, and carried transposons of the Tn916 family; CC-15 contained 23% of isolates, most of which were serotype 14, had the M phenotype, and carried mef(A) on Tn1207.1. Erythromycin resistance among S. pneumoniae isolates in New South Wales is mainly due to the dissemination of multidrug-resistant S. pneumoniae strains or horizontal spread of the Tn916 family of transposons.

语种: 英语
所属项目编号: 358351
项目资助者: NHMRC
WOS记录号: WOS:000274733300025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52781
Appears in Collections:北京大学第二临床医学院_皮科_期刊论文

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作者单位: 1.Westmead Hosp, ICPMR, CIDM, Westmead, NSW 2145, Australia
2.Shenzhen Second Peoples Hosp, Dept Lab Med, Shenzhen 518035, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Dermatol, Beijing 100044, Peoples R China
4.Peking Univ, Life Sci Coll, Beijing 100871, Peoples R China

Recommended Citation:
Xu, Xiaoping,Cai, Lin,Xiao, Meng,et al. Distribution of Serotypes, Genotypes, and Resistance Determinants among Macrolide-Resistant Streptococcus pneumoniae Isolates[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,2010,54(3):1152-1159.
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