IR@PKUHSC  > 北京大学第二临床医学院  > 皮科
学科主题临床医学
Distribution of Serotypes, Genotypes, and Resistance Determinants among Macrolide-Resistant Streptococcus pneumoniae Isolates
Xu, Xiaoping1,2; Cai, Lin1,3; Xiao, Meng1,4; Kong, Fanrong1; Oftadeh, Shahin1; Zhou, Fei1; Gilbert, Gwendolyn L.1
刊名ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
2010-03-01
DOI10.1128/AAC.01268-09
54期:3页:1152-1159
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Microbiology ; Pharmacology & Pharmacy
资助者NHMRC ; NHMRC
研究领域[WOS]Microbiology ; Pharmacology & Pharmacy
关键词[WOS]BLOT HYBRIDIZATION ASSAY ; EFFLUX GENE MEF(A) ; ERYTHROMYCIN RESISTANCE ; MOLECULAR EPIDEMIOLOGY ; MULTIPLEX PCR ; BETA-LACTAM ; ERM(B) ; TRANSPOSON ; ELEMENTS ; FLUOROQUINOLONE
英文摘要

Macrolide resistance in Streptococcus pneumoniae has emerged as an important clinical problem worldwide over the past decade. The aim of this study was to analyze the phenotypes (serotype and antibiotic susceptibility), genotypes (multilocus sequence type [MLST] and antibiotic resistance gene/transposon profiles) among the 31% (102/328) of invasive isolates from children in New South Wales, Australia, in 2005 that were resistant to erythromycin. Three serotypes-19F (47 isolates [46%]), 14 (27 isolates [26%]), and 6B (12 isolates [12%])-accounted for 86 (84%) of these 102 isolates. Seventy four (73%) isolates had the macrolide-lincosamide-streptogramin B (MLS(B)) resistance phenotype and carried Tn916 transposons (most commonly Tn6002); of these, 73 (99%) contained the erythromycin ribosomal methylase gene [erm(B)], 34 (47%) also carried the macrolide efflux gene [mef(E)], and 41 (55%) belonged to serotype 19F. Of 28 (27%) isolates with the M phenotype, 22 (79%) carried mef(A), including 16 (57%) belonging to serotype 14, and only six (19%) carried Tn916 transposons. Most (84%) isolates which contained mef also contained one of the msr(A) homologues, mel or msr(D); 38 of 40 (95%) isolates with mef(E) (on mega) carried mel, and of 28 (39%) isolates with mef(A), 10 (39%) carried mel and another 11(39%) carried msr(D), on Tn1207.1. Two predominant macrolide-resistant S. pneumoniae clonal clusters (CCs) were identified in this population. CC-271 contained 44% of isolates, most of which belonged to serotype 19F, had the MLS(B) phenotype, were multidrug resistant, and carried transposons of the Tn916 family; CC-15 contained 23% of isolates, most of which were serotype 14, had the M phenotype, and carried mef(A) on Tn1207.1. Erythromycin resistance among S. pneumoniae isolates in New South Wales is mainly due to the dissemination of multidrug-resistant S. pneumoniae strains or horizontal spread of the Tn916 family of transposons.

语种英语
所属项目编号358351
资助者NHMRC ; NHMRC
WOS记录号WOS:000274733300025
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52781
专题北京大学第二临床医学院_皮科
作者单位1.Westmead Hosp, ICPMR, CIDM, Westmead, NSW 2145, Australia
2.Shenzhen Second Peoples Hosp, Dept Lab Med, Shenzhen 518035, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Dermatol, Beijing 100044, Peoples R China
4.Peking Univ, Life Sci Coll, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Xu, Xiaoping,Cai, Lin,Xiao, Meng,et al. Distribution of Serotypes, Genotypes, and Resistance Determinants among Macrolide-Resistant Streptococcus pneumoniae Isolates[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,2010,54(3):1152-1159.
APA Xu, Xiaoping.,Cai, Lin.,Xiao, Meng.,Kong, Fanrong.,Oftadeh, Shahin.,...&Gilbert, Gwendolyn L..(2010).Distribution of Serotypes, Genotypes, and Resistance Determinants among Macrolide-Resistant Streptococcus pneumoniae Isolates.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,54(3),1152-1159.
MLA Xu, Xiaoping,et al."Distribution of Serotypes, Genotypes, and Resistance Determinants among Macrolide-Resistant Streptococcus pneumoniae Isolates".ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 54.3(2010):1152-1159.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xu, Xiaoping]的文章
[Cai, Lin]的文章
[Xiao, Meng]的文章
百度学术
百度学术中相似的文章
[Xu, Xiaoping]的文章
[Cai, Lin]的文章
[Xiao, Meng]的文章
必应学术
必应学术中相似的文章
[Xu, Xiaoping]的文章
[Cai, Lin]的文章
[Xiao, Meng]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。