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学科主题: 临床医学
题名:
Flow-Mediated Vasodilation as a Predictor of Therapeutic Response to Midodrine Hydrochloride in Children With Postural Orthostatic Tachycardia Syndrome
作者: Liao, Ying1; Yang, Jinyan1; Zhang, Fengwen1; Chen, Stella2; Liu, Xueqin1; Zhang, Qingyou1; Ai, Yi3; Wang, Yuli3; Tang, Chaoshu4; Du, Junbao1; Jin, Hongfang1
刊名: AMERICAN JOURNAL OF CARDIOLOGY
发表日期: 2013-09-15
DOI: 10.1016/j.amjcard.2013.05.008
卷: 112, 期:6, 页:816-820
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: ARTERY ; TILT
英文摘要:

This study was designed to explore the value of flow-mediated vasodilation (FMD) as a predictor of therapeutic response to midodrine hydrochloride (MD) in children with postural orthostatic tachycardia syndrome (POTS). One hundred and eight children diagnosed with POTS and 20 healthy control children were enrolled. All children with POTS received MD and were followed up for 3 months. FMD of brachial artery for each participant was measured by vascular ultrasound. Symptom scores, FMD values, and head-up test (HUT)/head-up tilt test (HUTT) outcomes were investigated before and after treatment. A receiver operating characteristic curve was used to explore the value of FMD as a predictor. Baseline FMD (%) and increased heart rate (beats per minute) during HUT/HUTT were significantly greater in children with POTS compared with control children (FMD: 11 +/- 3% vs 6 +/- 2%, p < 0.001; increased heart rate: 38 +/- 9 vs 7 +/- 7 beats/min, p < 0.001, respectively). Before treatment, MD responders had greater FMD values than MD nonresponders (p < 0.05). Symptom scores, excessive increases in heart rate during HUT, and increased FMD values were all reduced significantly after treatment (all p < 0.05). The receiver operating characteristic curve for the predictive value of FMD showed the area under the curve to be 0.790 (95% confidence interval: 0.679 to 0.902; p < 0.001) at 1-month and 0.803 (95% confidence interval: 0.669 to 0.936; p < 0.01) at 3-month therapy. FMD of 9.85% had a high sensitivity (1-month therapy: 71.6%; 3-month therapy: 74.4%) and specificity (1-month therapy 77.8%; 3-month therapy: 80%). In conclusion, FMD is a predictor of the efficacy of MD for treating children with POTS. (C) 2013 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2012BAI03B03 ; 2011CB503904
项目资助者: National Twelfth Five-Year Plan for Science &amp ; Technology Support of China ; Major Basic Research Project of China ; Initial Foundation for Youth of Peking University First Hospital
WOS记录号: WOS:000324900700011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52784
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Univ Calif San Diego, Dept Biochem & Cellular Biol, La Jolla, CA 92093 USA
3.Peking Univ, Hosp 1, Dept Pediat Ultrasound, Beijing 100034, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100034, Peoples R China

Recommended Citation:
Liao, Ying,Yang, Jinyan,Zhang, Fengwen,et al. Flow-Mediated Vasodilation as a Predictor of Therapeutic Response to Midodrine Hydrochloride in Children With Postural Orthostatic Tachycardia Syndrome[J]. AMERICAN JOURNAL OF CARDIOLOGY,2013,112(6):816-820.
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