IR@PKUHSC  > 北京大学第一临床医学院  > 儿科
学科主题临床医学
Flow-Mediated Vasodilation as a Predictor of Therapeutic Response to Midodrine Hydrochloride in Children With Postural Orthostatic Tachycardia Syndrome
Liao, Ying1; Yang, Jinyan1; Zhang, Fengwen1; Chen, Stella2; Liu, Xueqin1; Zhang, Qingyou1; Ai, Yi3; Wang, Yuli3; Tang, Chaoshu4; Du, Junbao1; Jin, Hongfang1
刊名AMERICAN JOURNAL OF CARDIOLOGY
2013-09-15
DOI10.1016/j.amjcard.2013.05.008
112期:6页:816-820
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]ARTERY ; TILT
英文摘要

This study was designed to explore the value of flow-mediated vasodilation (FMD) as a predictor of therapeutic response to midodrine hydrochloride (MD) in children with postural orthostatic tachycardia syndrome (POTS). One hundred and eight children diagnosed with POTS and 20 healthy control children were enrolled. All children with POTS received MD and were followed up for 3 months. FMD of brachial artery for each participant was measured by vascular ultrasound. Symptom scores, FMD values, and head-up test (HUT)/head-up tilt test (HUTT) outcomes were investigated before and after treatment. A receiver operating characteristic curve was used to explore the value of FMD as a predictor. Baseline FMD (%) and increased heart rate (beats per minute) during HUT/HUTT were significantly greater in children with POTS compared with control children (FMD: 11 +/- 3% vs 6 +/- 2%, p < 0.001; increased heart rate: 38 +/- 9 vs 7 +/- 7 beats/min, p < 0.001, respectively). Before treatment, MD responders had greater FMD values than MD nonresponders (p < 0.05). Symptom scores, excessive increases in heart rate during HUT, and increased FMD values were all reduced significantly after treatment (all p < 0.05). The receiver operating characteristic curve for the predictive value of FMD showed the area under the curve to be 0.790 (95% confidence interval: 0.679 to 0.902; p < 0.001) at 1-month and 0.803 (95% confidence interval: 0.669 to 0.936; p < 0.01) at 3-month therapy. FMD of 9.85% had a high sensitivity (1-month therapy: 71.6%; 3-month therapy: 74.4%) and specificity (1-month therapy 77.8%; 3-month therapy: 80%). In conclusion, FMD is a predictor of the efficacy of MD for treating children with POTS. (C) 2013 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000324900700011
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52784
专题北京大学第一临床医学院_儿科
北京大学基础医学院
作者单位1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Univ Calif San Diego, Dept Biochem & Cellular Biol, La Jolla, CA 92093 USA
3.Peking Univ, Hosp 1, Dept Pediat Ultrasound, Beijing 100034, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Liao, Ying,Yang, Jinyan,Zhang, Fengwen,et al. Flow-Mediated Vasodilation as a Predictor of Therapeutic Response to Midodrine Hydrochloride in Children With Postural Orthostatic Tachycardia Syndrome[J]. AMERICAN JOURNAL OF CARDIOLOGY,2013,112(6):816-820.
APA Liao, Ying.,Yang, Jinyan.,Zhang, Fengwen.,Chen, Stella.,Liu, Xueqin.,...&Jin, Hongfang.(2013).Flow-Mediated Vasodilation as a Predictor of Therapeutic Response to Midodrine Hydrochloride in Children With Postural Orthostatic Tachycardia Syndrome.AMERICAN JOURNAL OF CARDIOLOGY,112(6),816-820.
MLA Liao, Ying,et al."Flow-Mediated Vasodilation as a Predictor of Therapeutic Response to Midodrine Hydrochloride in Children With Postural Orthostatic Tachycardia Syndrome".AMERICAN JOURNAL OF CARDIOLOGY 112.6(2013):816-820.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Flow-Mediated Vasodi(127KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liao, Ying]的文章
[Yang, Jinyan]的文章
[Zhang, Fengwen]的文章
百度学术
百度学术中相似的文章
[Liao, Ying]的文章
[Yang, Jinyan]的文章
[Zhang, Fengwen]的文章
必应学术
必应学术中相似的文章
[Liao, Ying]的文章
[Yang, Jinyan]的文章
[Zhang, Fengwen]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Flow-Mediated Vasodilation as a Predictor of Therapeutic Response to Midodrine Hydrochloride in Children With Postural Orthostatic Tachycardia Syndrome.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。