IR@PKUHSC  > 北京大学基础医学院  > 心血管所
学科主题基础医学
PPAR delta Activation Protects Endothelial Function in Diabetic Mice
Tian, Xiao Yu1; Wong, Wing Tak1,2; Wang, Nanping3,4; Lu, Ye1; Cheang, Wai San1; Liu, Jian1; Liu, Limei1,5; Liu, Yahan4; Lee, Susanna Sau-Tuen6; Chen, Zhen Yu6; Cooke, John P.2; Yao, Xiaoqiang1; Huang, Yu1
刊名DIABETES
2012-12-01
DOI10.2337/db12-0117
61期:12页:3285-3293
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]INFLAMMATORY ADHESION MOLECULES ; RECEPTOR-DELTA ; SIGNALING PATHWAY ; OXIDATIVE STRESS ; PROGENITOR CELLS ; INSULIN SENSITIVITY ; LIPID-PEROXIDATION ; ACID OXIDATION ; UP-REGULATION ; GAMMA
英文摘要

Recent evidence highlights the therapeutic potential of peroxisome proliferator-activated receptor-delta (PPAR delta) agonists to increase insulin sensitivity hi diabetes. However, the role of PPAR delta in regulating vascular function is incompletely characterized. We investigate whether PPAR delta activation improves endothelial function in diabetic and obese mice. PPAR delta knockout (KO) and wild-type (WT) mice fed with high-fat diet and db/db mice were used as diabetic mouse models, compared with PPAR delta KO and WT mice on normal diet and db/m(+) mice. Endothelium-dependent relaxation (EDR) was measured by wire myograph. Flow-mediated vasodilatation (FMD) was measured by pressure myograph. Nitric oxide (NO) production was examined in primary endothelial cells from mouse aortae. PPAR delta agonist GW1516 restored EDRs in mouse aortae under high-glucose conditions or in db/db mouse aortae ex vivo. After oral treatment with GW1516, EDRs in aortae and FMDs in mesenteric resistance arteries were improved in obese mice in a PPAR delta-specific manner. The effects of GW1516 on endothelial function were mediated through phosphatidylinositol 3-kinase (PI3K) and Ala with a subsequent increase of endothelial nitric oxide synthase (eNOS) activity and NO production. The current study demonstrates an endothelial-protective effect of PPAR delta agonists in diabetic mice through PI3K/Akt/eNOS signaling, suggesting the therapeutic potential of PPAR delta agonists for diabetic vasculopathy. Diabetes 61:3285-3293, 2012

语种英语
WOS记录号WOS:000312041700036
项目编号N_CUHK428/09 ; 30890041 ; 30931160434 ; 2010CB912502 ; 2012CB517805 ; 2140676 ; 465611
资助机构Natural Science Foundation of China/Research Grants Council of Hong Kong Joint Research Scheme ; National Science Foundation of China ; Ministry of Science and Technology of China (973 programs) ; Hong Kong General Research Fund
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52789
专题北京大学基础医学院_心血管所
北京大学基础医学院
作者单位1.Chinese Univ Hong Kong, Inst Vasc Med, Li Ka Shing Inst Hlth Sci, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China
2.Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA
3.Xi An Jiao Tong Univ, Cardiovasc Res Ctr, Xian 710049, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100871, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100871, Peoples R China
6.Chinese Univ Hong Kong, Sch Life Sci, Hong Kong, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Tian, Xiao Yu,Wong, Wing Tak,Wang, Nanping,et al. PPAR delta Activation Protects Endothelial Function in Diabetic Mice[J]. DIABETES,2012,61(12):3285-3293.
APA Tian, Xiao Yu.,Wong, Wing Tak.,Wang, Nanping.,Lu, Ye.,Cheang, Wai San.,...&Huang, Yu.(2012).PPAR delta Activation Protects Endothelial Function in Diabetic Mice.DIABETES,61(12),3285-3293.
MLA Tian, Xiao Yu,et al."PPAR delta Activation Protects Endothelial Function in Diabetic Mice".DIABETES 61.12(2012):3285-3293.
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