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学科主题: 临床医学
题名:
Association between CHEK2 H371Y mutation and response to neoadjuvant chemotherapy in women with breast cancer
作者: Liu, Yin; Xu, Ye; Ouyang, Tao; Li, Jinfeng; Wang, Tianfeng; Fan, Zhaoqing; Fan, Tie; Lin, Benyao; Xie, Yuntao
刊名: BMC CANCER
发表日期: 2015-03-28
DOI: 10.1186/s12885-015-1203-3
卷: 15
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: PATHOLOGICAL COMPLETE RESPONSE ; CHECKPOINT KINASE CHK2 ; POLY(ADP-RIBOSE) POLYMERASE ; TUMOR CHARACTERISTICS ; GERMLINE MUTATION ; YOUNG-WOMEN ; DNA-DAMAGE ; CHEK2-ASTERISK-1100DELC ; POPULATION ; CELLS
英文摘要:

Background: Our previous study suggested that the recurrent CHEK2 H371Y mutation is a novel pathogenic mutation that confers an increased risk of breast cancer. The purpose of this study was to investigate whether breast cancer patients with CHEK2 H371Y mutation were more likely to respond to neoadjuvant chemotherapy. Methods: We screened a cohort of 2334 Chinese women with operable primary breast cancer who received a neoadjuvant chemotherapy regimen for CHEK2 H371Y germline mutations. Pathologic complete response ( pCR) was defined as the absence of tumor cells in the breast after the completion of neoadjuvant chemotherapy. Results: Thirty- nine patients ( 1.7%) with CHEK2 H371Y germline mutation were identified in this cohort of 2334 patients. CHEK2 H371Y mutation carriers had a significantly higher pCR rate than non- carriers ( 33.3% versus 19.5%, P = 0.031) in the entire study population, and CHEK2 H371Y mutation- positive status remained an independent favorable predictor of pCR in a multivariate analysis ( odds ratio [ OR] = 3.01; 95% confidence interval [ CI]: 1.34- 6.78, P = 0.008). CHEK2 H371Y carriers had a slightly worse distant recurrence- free survival than non- carriers ( adjusted hazard ratio [ HR] = 1.24, 95% CI: 0.59- 2.63). Conclusions: CHEK2 H371Y mutation carriers are more likely to respond to neoadjuvant chemotherapy than are non- carriers.

语种: 英语
WOS记录号: WOS:000351813400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52790
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: Peking Univ, Canc Hosp, Beijing Canc Hosp & Inst,Minist Educ, Breast Ctr,Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China

Recommended Citation:
Liu, Yin,Xu, Ye,Ouyang, Tao,et al. Association between CHEK2 H371Y mutation and response to neoadjuvant chemotherapy in women with breast cancer[J]. BMC CANCER,2015,15.
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