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学科主题: 基础医学
题名:
HLA Associations in Classical Hodgkin Lymphoma: EBV Status Matters
作者: Huang, Xin1,2; Kushekhar, Kushi1; Nolte, Ilja3; Kooistra, Wierd1; Visser, Lydia1; Bouwman, Ilby5; Kouprie, Niels5; Veenstra, Rianne1; van Imhoff, Gustaaf4; Olver, Bianca6; Houlston, Richard S.6; Poppema, Sibrand1; Diepstra, Arjan1; Hepkema, Bouke5; van den Berg, Anke1
刊名: PLOS ONE
发表日期: 2012-07-10
DOI: 10.1371/journal.pone.0039986
卷: 7, 期:7
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: EPSTEIN-BARR-VIRUS ; GENOME-WIDE ASSOCIATION ; CLASS-I ; NASOPHARYNGEAL CARCINOMA ; DISEASE ; ALLELES ; PROTEIN ; EPITOPE ; SUSCEPTIBILITY ; EPIDEMIOLOGY
英文摘要:

The pathogenesis of classical Hodgkin lymphoma (cHL) involves environmental and genetic factors. To explore the role of the human leukocyte antigen (HLA) genes, we performed a case-control genotyping study in 338 Dutch cHL patients using a PCR-based sequence-specific oligonucleotide probe (SSOP) hybridization approach. The allele frequencies were compared to HLA typings of more than 6,000 controls. The age of the cHL patients varied between 13 and 81 years with a median of 35 years. Nodular sclerosis subtype was the most common subtype (87%) and EBV was detected in 25% of the cHL patients. HLA-B5 was significantly increased and HLA-DR7 significantly decreased in the total cHL patient population as compared to controls. Two class II associations were observed to be specific for the EBV- cHL population with an increase of HLA-DR2 and HLA-DR5. Allele frequencies of HLA-A1, HLA-B37 and HLA-DR10 were significantly increased in the EBV+ cHL population; these alleles are in strong linkage disequilibrium and form a common haplotype in Caucasians. The allele frequency of HLA-A2 was significantly decreased in the EBV+ cHL population. Analysis of haplotypes with a frequency of >1% revealed a significant increase of HLA-A2-B7-DR2 in EBV- cHL as compared to controls. SSOP association analysis revealed significant differences between EBV+ and EBV- cHL patients for 19 probes that discriminate between HLA-A*01 and HLA-A*02. In conclusion, the HLA-A1 and HLA-A2 antigens and not specific single nucleotide variants shared by multiple alleles are responsible for the association with EBV+ cHL. Furthermore several new protective and predisposing HLA class I and II associations for the EBV+, the EBV- and the entire cHL population were identified.

语种: 英语
所属项目编号: KWF: RUG 20094313
项目资助者: Bernoulli Bursary, University Medical Center Groningen ; Dutch Cancer Society
WOS记录号: WOS:000306355500019
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52793
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands
2.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100871, Peoples R China
3.Univ Groningen, Dept Epidemiol, Univ Med Ctr Groningen, Groningen, Netherlands
4.Univ Groningen, Dept Hematol, Univ Med Ctr Groningen, Groningen, Netherlands
5.Univ Groningen, Dept Lab Med, Univ Med Ctr Groningen, Groningen, Netherlands
6.Inst Canc Res, Sect Canc Genet, Sutton, Surrey, England

Recommended Citation:
Huang, Xin,Kushekhar, Kushi,Nolte, Ilja,et al. HLA Associations in Classical Hodgkin Lymphoma: EBV Status Matters[J]. PLOS ONE,2012,7(7).
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