IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
HLA Associations in Classical Hodgkin Lymphoma: EBV Status Matters
Huang, Xin1,2; Kushekhar, Kushi1; Nolte, Ilja3; Kooistra, Wierd1; Visser, Lydia1; Bouwman, Ilby5; Kouprie, Niels5; Veenstra, Rianne1; van Imhoff, Gustaaf4; Olver, Bianca6; Houlston, Richard S.6; Poppema, Sibrand1; Diepstra, Arjan1; Hepkema, Bouke5; van den Berg, Anke1
刊名PLOS ONE
2012-07-10
DOI10.1371/journal.pone.0039986
7期:7
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]EPSTEIN-BARR-VIRUS ; GENOME-WIDE ASSOCIATION ; CLASS-I ; NASOPHARYNGEAL CARCINOMA ; DISEASE ; ALLELES ; PROTEIN ; EPITOPE ; SUSCEPTIBILITY ; EPIDEMIOLOGY
英文摘要

The pathogenesis of classical Hodgkin lymphoma (cHL) involves environmental and genetic factors. To explore the role of the human leukocyte antigen (HLA) genes, we performed a case-control genotyping study in 338 Dutch cHL patients using a PCR-based sequence-specific oligonucleotide probe (SSOP) hybridization approach. The allele frequencies were compared to HLA typings of more than 6,000 controls. The age of the cHL patients varied between 13 and 81 years with a median of 35 years. Nodular sclerosis subtype was the most common subtype (87%) and EBV was detected in 25% of the cHL patients. HLA-B5 was significantly increased and HLA-DR7 significantly decreased in the total cHL patient population as compared to controls. Two class II associations were observed to be specific for the EBV- cHL population with an increase of HLA-DR2 and HLA-DR5. Allele frequencies of HLA-A1, HLA-B37 and HLA-DR10 were significantly increased in the EBV+ cHL population; these alleles are in strong linkage disequilibrium and form a common haplotype in Caucasians. The allele frequency of HLA-A2 was significantly decreased in the EBV+ cHL population. Analysis of haplotypes with a frequency of >1% revealed a significant increase of HLA-A2-B7-DR2 in EBV- cHL as compared to controls. SSOP association analysis revealed significant differences between EBV+ and EBV- cHL patients for 19 probes that discriminate between HLA-A*01 and HLA-A*02. In conclusion, the HLA-A1 and HLA-A2 antigens and not specific single nucleotide variants shared by multiple alleles are responsible for the association with EBV+ cHL. Furthermore several new protective and predisposing HLA class I and II associations for the EBV+, the EBV- and the entire cHL population were identified.

语种英语
WOS记录号WOS:000306355500019
项目编号KWF: RUG 20094313
资助机构Bernoulli Bursary, University Medical Center Groningen ; Dutch Cancer Society
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52793
专题北京大学基础医学院_病理学系
作者单位1.Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands
2.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100871, Peoples R China
3.Univ Groningen, Dept Epidemiol, Univ Med Ctr Groningen, Groningen, Netherlands
4.Univ Groningen, Dept Hematol, Univ Med Ctr Groningen, Groningen, Netherlands
5.Univ Groningen, Dept Lab Med, Univ Med Ctr Groningen, Groningen, Netherlands
6.Inst Canc Res, Sect Canc Genet, Sutton, Surrey, England
推荐引用方式
GB/T 7714
Huang, Xin,Kushekhar, Kushi,Nolte, Ilja,et al. HLA Associations in Classical Hodgkin Lymphoma: EBV Status Matters[J]. PLOS ONE,2012,7(7).
APA Huang, Xin.,Kushekhar, Kushi.,Nolte, Ilja.,Kooistra, Wierd.,Visser, Lydia.,...&van den Berg, Anke.(2012).HLA Associations in Classical Hodgkin Lymphoma: EBV Status Matters.PLOS ONE,7(7).
MLA Huang, Xin,et al."HLA Associations in Classical Hodgkin Lymphoma: EBV Status Matters".PLOS ONE 7.7(2012).
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