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学科主题: 临床医学
题名:
Prevalence and risk factors of Helicobacter pylori infection in asymptomatic Chinese children: a prospective, cross-sectional, population-based study
作者: Ding, Z.1; Zhao, S.1; Gong, S.2; Li, Z.3; Mao, M.4; Xu, X.1; Zhou, L.3
刊名: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
发表日期: 2015-10-01
DOI: 10.1111/apt.13364
卷: 42, 期:8, 页:1019-1026
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Pharmacology & Pharmacy
研究领域[WOS]: Gastroenterology & Hepatology ; Pharmacology & Pharmacy
关键词[WOS]: GASTRIC-CANCER ; EARLY-CHILDHOOD ; ENZYME-IMMUNOASSAY ; SOUTHERN CHINA ; EPIDEMIOLOGY ; STOOL ; ANTIGEN ; ACQUISITION ; DIAGNOSIS ; SEROPREVALENCE
英文摘要:

Background

Limited research has been published on current Helicobacter pylori infection rate in asymptomatic children in China.

Aim

To assess current Helicobacter pylori infection rate, distribution characteristics and risk factors in Chinese asymptomatic children.

Methods

A prospective, cross-sectional, population-based study was performed from 2009 to 2011 in three cities of China. Helicobacter pylori infection was diagnosed by a stool antigen test. Multi-stage cluster random sampling was used to select asymptomatic children including neonates. Socioeconomic details were obtained through a standardised questionnaire.

Results

Among total of 3491 children (0-18 years), the global infection rate was 6.8% and there were no significant differences between genders. Age specific infection rate between regions was significantly different (P < 0.05). The infection rate significantly increased with age (P for trend <0.01). It was low during the newborn (0.6%) to preschool period and was significantly increased in high school students (13.5%) (P < 0.01). Multivariable regression indicated that hand sanitisation, individually served meals, higher education level of mother, above average living space and residence in urban areas were significantly protective against infection (OR 0.749, 0.698, 0.720, 0.838 and 0.770 respectively). Conversely, consuming meals in unsanitised conditions, sharing towels, receiving pre-chewed food from the mother, artificial feeding and family history of gastrointestinal disease were significantly associated with the risk of infection (OR 1.200, 1.965, 2.002, 1.071 and 2.093 respectively).

Conclusions

Helicobacter pylori infection rate increases with age in Chinese asymptomatic children and is common after 10 years of age. The rate of infection is related to socioeconomic status.

语种: 英语
所属项目编号: 2007BAI04B02
项目资助者: National Science &amp ; Technology Pillar Program of China
WOS记录号: WOS:000362447400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52795
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Childrens Hosp, Dept Gastroenterol, Beijing 100045, Peoples R China
2.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Dept Gastroenterol, Guangzhou, Guangdong, Peoples R China
3.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100871, Peoples R China
4.Sichuan Univ, West China Hosp 2, Dept Pediat, Chengdu 610064, Peoples R China

Recommended Citation:
Ding, Z.,Zhao, S.,Gong, S.,et al. Prevalence and risk factors of Helicobacter pylori infection in asymptomatic Chinese children: a prospective, cross-sectional, population-based study[J]. ALIMENTARY PHARMACOLOGY &amp; THERAPEUTICS,2015,42(8):1019-1026.
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