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Synthesis, Characterization, and In Vivo Biodistribution of I-125-Labeled Dex-g-PMAGGCONHTyr
Wang, Deqian1,2; Shi, Jiyun3; Tan, Junjun1; Jin, Xin1,2; Li, Qinmei1,2; Kang, Honglang1; Liu, Ruigang1; Jia, Bing3; Huang, Yong1,4,5
刊名BIOMACROMOLECULES
2011-05-01
DOI10.1021/bm200194s
12期:5页:1851-1859
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science
资助者National Natural Science Foundation of China ; Chinese Academy of Sciences ; National Natural Science Foundation of China ; Chinese Academy of Sciences
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
关键词[WOS]SENTINEL NODE DETECTION ; WATER-SOLUBLE POLYMERS ; CROSS-LINKED COLLAGEN ; DRUG-DELIVERY ; MACROMOLECULAR THERAPEUTICS ; GRAFT-COPOLYMERIZATION ; ALZHEIMERS-DISEASE ; IMAGING AGENTS ; NANOPARTICLES ; ACCUMULATION
英文摘要

Dextran graft poly (N-methacryloylglycylglycine) copolymer-tyrosine conjugates (dextran-g-PMAGGCONHTyr) were synthesized and characterized. Dynamic light scattering (DLS) results indicated that the graft copolymers are soluble in pH 7.4 PBS and 0.9% saline solutions. The graft copolymers were labeled with I-125, and the labeling stability in 0.9% saline solution was investigated. Pharmacokinetics studies showed a rapid clearance of I-125-labeled graft copolymers from the blood pool. Biodistribution images confirmed the preferable liver and spleen accumulation within 1 h after injection and rapid clearance from all the organs over time. The graft copolymer with molecular weight of 9.8 kDa was eliminated from the kidney significantly faster than those with higher molecular weight. The effect of the numbers of -COOH groups on the graft copolymers on the biodistribution was also investigated. It was found that the graft copolymers with the average number of -COOH groups per glucopyranose unit (DS-COOH) of 0.57 and 0.18 are mainly distributed in liver and spleen at 1 h after injection, whereas the graft copolymer with DS-COOH of 0.07 is mainly accumulated in kidney.

语种英语
所属项目编号20974114 ; 20774105 ; 50821062 ; KJCX2-YW-H19
资助者National Natural Science Foundation of China ; Chinese Academy of Sciences ; National Natural Science Foundation of China ; Chinese Academy of Sciences
WOS记录号WOS:000290246400051
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52796
专题北京大学医药卫生分析中心
作者单位1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Lab Polymer Phys & Chem, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
3.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China
4.Chinese Acad Sci, Tech Inst Phys & Chem, Nat Res Ctr Engn Plast, Beijing 100190, Peoples R China
5.Chinese Acad Sci, Guangzhou Inst Chem, Lab Cellulose & Lignocellulos Chem, Guangzhou 510650, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Wang, Deqian,Shi, Jiyun,Tan, Junjun,et al. Synthesis, Characterization, and In Vivo Biodistribution of I-125-Labeled Dex-g-PMAGGCONHTyr[J]. BIOMACROMOLECULES,2011,12(5):1851-1859.
APA Wang, Deqian.,Shi, Jiyun.,Tan, Junjun.,Jin, Xin.,Li, Qinmei.,...&Huang, Yong.(2011).Synthesis, Characterization, and In Vivo Biodistribution of I-125-Labeled Dex-g-PMAGGCONHTyr.BIOMACROMOLECULES,12(5),1851-1859.
MLA Wang, Deqian,et al."Synthesis, Characterization, and In Vivo Biodistribution of I-125-Labeled Dex-g-PMAGGCONHTyr".BIOMACROMOLECULES 12.5(2011):1851-1859.
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