IR@PKUHSC  > 基础医学院  > 病原生物学系
学科主题基础医学
Mutations in Fbx4 inhibit dimerization of the SCFFbx4 ligase and contribute to cyclin D1 overexpression in human cancer
Barbash, Olena1,2; Zamfirova, Petia1; Lin, Douglas I.1,2; Chen, Xiangmei5; Yang, Ke5; Nakagawa, Hiroshi3,4; Lu, Fengmin5; Rustgi, Anil K.3,4; Diehl, J. Alan1,2
刊名CANCER CELL
2008-07-01
DOI10.1016/j.ccr.2008.05.017
14期:1页:68-78
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Cell Biology
研究领域[WOS]Oncology ; Cell Biology
关键词[WOS]PHOSPHORYLATION-DEPENDENT UBIQUITINATION ; F-BOX PROTEINS ; BREAST-CANCER ; NUCLEAR EXPORT ; PROTEOLYSIS ; DEGRADATION ; EXPRESSION ; COMPLEX ; KINASE ; ONCOGENE
英文摘要

SCFFbx4 was recently identified as the E3 ligase for cyclin D1. We now describe cell-cycle-dependent phosphorylation and dimerization of Fbx4 that is regulated by GSK3 beta and is defective in human cancer. We present data demonstrating that a pathway involving Ras-Akt-GSK3 beta controls the temporal phosphorylation and dimerization of the SCFFbx4 E3 ligase. Inhibition of Fbx4 activity results in accumulation of nuclear cyclin D1 and oncogenic transformation. The importance of this regulatory pathway for normal cell growth is emphasized by the prevalence of mutations in Fbx4 in human cancer that impair dimerization. Collectively, these data reveal that inactivation of the cyclin D1 E3 ligase likely contributes to cyclin D1 overexpression in a significant fraction of human cancer.

语种英语
WOS记录号WOS:000257655100010
引用统计
被引频次:92[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52804
专题基础医学院_病原生物学系
作者单位1.Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA
2.Univ Penn, Sch Med, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA
3.Univ Penn, Sch Med, Dept Canc Biol, Philadelphia, PA 19104 USA
4.Univ Penn, Sch Med, Dept Med, Div Gastroenterol, Philadelphia, PA 19104 USA
5.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Barbash, Olena,Zamfirova, Petia,Lin, Douglas I.,et al. Mutations in Fbx4 inhibit dimerization of the SCFFbx4 ligase and contribute to cyclin D1 overexpression in human cancer[J]. CANCER CELL,2008,14(1):68-78.
APA Barbash, Olena.,Zamfirova, Petia.,Lin, Douglas I..,Chen, Xiangmei.,Yang, Ke.,...&Diehl, J. Alan.(2008).Mutations in Fbx4 inhibit dimerization of the SCFFbx4 ligase and contribute to cyclin D1 overexpression in human cancer.CANCER CELL,14(1),68-78.
MLA Barbash, Olena,et al."Mutations in Fbx4 inhibit dimerization of the SCFFbx4 ligase and contribute to cyclin D1 overexpression in human cancer".CANCER CELL 14.1(2008):68-78.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Mutations in Fbx4 in(1345KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Barbash, Olena]的文章
[Zamfirova, Petia]的文章
[Lin, Douglas I.]的文章
百度学术
百度学术中相似的文章
[Barbash, Olena]的文章
[Zamfirova, Petia]的文章
[Lin, Douglas I.]的文章
必应学术
必应学术中相似的文章
[Barbash, Olena]的文章
[Zamfirova, Petia]的文章
[Lin, Douglas I.]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Mutations in Fbx4 inhibit dimerization of the SCFFbx4 ligase and contribute to cyclin D1 overexpression in human cancer.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。