IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
Mutations in the ELANE Gene are Associated with Development of Periodontitis in Patients with Severe Congenital Neutropenia
Ye, Ying1,5; Carlsson, Goran2; Wondimu, Biniyam1; Fahlen, Annika3; Karlsson-Sjoberg, Jenny4; Andersson, Mats4; Engstrand, Lars3; Yucel-Lindberg, Tulay1; Modeer, Thomas1; Putsep, Katrin4
关键词Kostmann Neutropenia Neutrophil Elastase 2 Periodontal Diseases Subgingival Microflora
刊名JOURNAL OF CLINICAL IMMUNOLOGY
2011-12-01
DOI10.1007/s10875-011-9572-0
31期:6页:936-945
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]GINGIVAL CREVICULAR FLUID ; COLONY-STIMULATING FACTOR ; UNFOLDED PROTEIN RESPONSE ; ORIGINAL KOSTMANN FAMILY ; NECROSIS-FACTOR-ALPHA ; CYCLIC NEUTROPENIA ; PEPTIDE LL-37 ; REFRACTORY PERIODONTITIS ; ANTIMICROBIAL PEPTIDES ; ADULT PERIODONTITIS
英文摘要

Patients with severe congenital neutropenia (SCN) often develop periodontitis despite standard medical and dental care. In light of previous findings that mutations in the neutrophil elastase gene, ELANE, are associated with more severe neutropenic phenotypes, we hypothesized an association between the genotype of SCN and development of periodontitis.

Fourteen Swedish patients with SCN or cyclic neutropenia harboring different genetic backgrounds were recruited for periodontal examination. Peripheral blood, gingival crevicular fluid (GCF), and subgingival bacterial samples were collected. The levels of cytokines and antibacterial peptides were determined in GCF and plasma by multiplex immunoassay and immunoblotting, respectively. Subgingival bacterial samples were analyzed using 16S rDNA pyrosequencing.

ELANE mutations correlated with more severe periodontal status than the HAX1 or unknown mutations in patients with SCN. The subjects with mutant ELANE had higher levels of IL-1 beta in GCF. Using principal coordinate analysis of the subgingival microbiota, patients with ELANE mutations and reference subjects with periodontitis tended to cluster differently from patients with HAX1 or unknown mutations and non-periodontitis reference subjects.

This study demonstrates an association between ELANE mutations in SCN and the development of periodontitis with skewed subgingival microbiota, indicating a potential role of ELANE mutations in the pathogenesis of periodontitis.

语种英语
WOS记录号WOS:000297522500002
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52805
专题北京大学口腔医学院
作者单位1.Swedish Inst Infect Dis Control, Solna, Sweden
2.Peking Univ, Sch Stomatol, Beijing 100871, Peoples R China
3.Karolinska Inst, Div Pediat Dent, Dept Dent Med, S-14104 Huddinge, Sweden
4.Karolinska Inst, Karolinska Univ Hosp, Dept Womans & Childrens Hlth, Childhood Canc Res Unit, Stockholm, Sweden
5.Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Solna, Sweden
推荐引用方式
GB/T 7714
Ye, Ying,Carlsson, Goran,Wondimu, Biniyam,et al. Mutations in the ELANE Gene are Associated with Development of Periodontitis in Patients with Severe Congenital Neutropenia[J]. JOURNAL OF CLINICAL IMMUNOLOGY,2011,31(6):936-945.
APA Ye, Ying.,Carlsson, Goran.,Wondimu, Biniyam.,Fahlen, Annika.,Karlsson-Sjoberg, Jenny.,...&Putsep, Katrin.(2011).Mutations in the ELANE Gene are Associated with Development of Periodontitis in Patients with Severe Congenital Neutropenia.JOURNAL OF CLINICAL IMMUNOLOGY,31(6),936-945.
MLA Ye, Ying,et al."Mutations in the ELANE Gene are Associated with Development of Periodontitis in Patients with Severe Congenital Neutropenia".JOURNAL OF CLINICAL IMMUNOLOGY 31.6(2011):936-945.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Ye, Ying]的文章
[Carlsson, Goran]的文章
[Wondimu, Biniyam]的文章
百度学术
百度学术中相似的文章
[Ye, Ying]的文章
[Carlsson, Goran]的文章
[Wondimu, Biniyam]的文章
必应学术
必应学术中相似的文章
[Ye, Ying]的文章
[Carlsson, Goran]的文章
[Wondimu, Biniyam]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。