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学科主题临床医学
miR-1/miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes
Shan, Zhi-Xin1; Lin, Qiu-Xiong1; Deng, Chun-Yu1; Zhu, Jie-Ning1; Mai, Li-Ping1; Liu, Ju-Li1; Fu, Yong-Heng1; Liu, Xiao-Ying1; Li, Yang-Xin2,3; Zhang, You-Yi4; Lin, Shu-Guang1; Yu, Xi-Yong1
关键词Mir-1 Mir-206 Hsp60 High Glucose H9c2 Cell
刊名FEBS LETTERS
2010-08-20
DOI10.1016/j.febslet.2010.07.027
584期:16页:3592-3600
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]MUSCLE-SPECIFIC MICRORNA ; CARDIAC-MUSCLE ; HEART-FAILURE ; DIABETIC CARDIOMYOPATHY ; GROWTH-FACTOR ; I RECEPTOR ; MITOCHONDRIA ; STRESS ; HSP10 ; GENE
英文摘要

Hsp60 is an important component of defense mechanisms against diabetic myocardial injury; however, the cause of Hsp60 reduction in the diabetic myocardium remains unknown. After stimulation of cardiomyocytes with high glucose in vivo and in vitro, significant up-regulation of miR-1/miR-206 and post-transcriptional modulation of Hsp 60 were observed. Serum response factor (SRF) and the MEK1/2 pathway were involved in miR-1 and miR-206 expression in cardiomyocytes. miR-1 and miR-206 regulated Hsp60 expression post-transcriptionally and accelerated cardiomyocyte apoptosis through Hsp60. These results revealed that miR-1 and miR-206 regulate Hsp60 expression, contributing to high glucose-mediated apoptosis in cardiomyocytes. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

语种英语
WOS记录号WOS:000280894800015
项目编号30672077 ; 30772142 ; 2006CB503806
资助机构National Natural Science Foundation of China ; National Key Basic Research Program (NKBRP) of China
引用统计
被引频次:113[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52810
专题北京大学第三临床医学院_心血管内科
作者单位1.Univ Texas Hlth Sci Ctr, Houston, TX 77030 USA
2.Guangdong Gen Hosp, Res Ctr, Guangdong Prov Cardiovasc Inst, Guangdong Acad Med Sci, Guangzhou 510080, Guangdong, Peoples R China
3.St Lukes Episcopal Hosp, Texas Heart Inst, Houston, TX 77030 USA
4.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100083, Peoples R China
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Shan, Zhi-Xin,Lin, Qiu-Xiong,Deng, Chun-Yu,et al. miR-1/miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes[J]. FEBS LETTERS,2010,584(16):3592-3600.
APA Shan, Zhi-Xin.,Lin, Qiu-Xiong.,Deng, Chun-Yu.,Zhu, Jie-Ning.,Mai, Li-Ping.,...&Yu, Xi-Yong.(2010).miR-1/miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes.FEBS LETTERS,584(16),3592-3600.
MLA Shan, Zhi-Xin,et al."miR-1/miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes".FEBS LETTERS 584.16(2010):3592-3600.
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