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IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
miR-1/miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes
作者: Shan, Zhi-Xin1; Lin, Qiu-Xiong1; Deng, Chun-Yu1; Zhu, Jie-Ning1; Mai, Li-Ping1; Liu, Ju-Li1; Fu, Yong-Heng1; Liu, Xiao-Ying1; Li, Yang-Xin2,3; Zhang, You-Yi4; Lin, Shu-Guang1; Yu, Xi-Yong1
关键词: miR-1 ; miR-206 ; Hsp60 ; High glucose ; H9c2 cell
刊名: FEBS LETTERS
发表日期: 2010-08-20
DOI: 10.1016/j.febslet.2010.07.027
卷: 584, 期:16, 页:3592-3600
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]: MUSCLE-SPECIFIC MICRORNA ; CARDIAC-MUSCLE ; HEART-FAILURE ; DIABETIC CARDIOMYOPATHY ; GROWTH-FACTOR ; I RECEPTOR ; MITOCHONDRIA ; STRESS ; HSP10 ; GENE
英文摘要:

Hsp60 is an important component of defense mechanisms against diabetic myocardial injury; however, the cause of Hsp60 reduction in the diabetic myocardium remains unknown. After stimulation of cardiomyocytes with high glucose in vivo and in vitro, significant up-regulation of miR-1/miR-206 and post-transcriptional modulation of Hsp 60 were observed. Serum response factor (SRF) and the MEK1/2 pathway were involved in miR-1 and miR-206 expression in cardiomyocytes. miR-1 and miR-206 regulated Hsp60 expression post-transcriptionally and accelerated cardiomyocyte apoptosis through Hsp60. These results revealed that miR-1 and miR-206 regulate Hsp60 expression, contributing to high glucose-mediated apoptosis in cardiomyocytes. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

语种: 英语
所属项目编号: 30672077 ; 30772142 ; 2006CB503806
项目资助者: National Natural Science Foundation of China ; National Key Basic Research Program (NKBRP) of China
WOS记录号: WOS:000280894800015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52810
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Univ Texas Hlth Sci Ctr, Houston, TX 77030 USA
2.Guangdong Gen Hosp, Res Ctr, Guangdong Prov Cardiovasc Inst, Guangdong Acad Med Sci, Guangzhou 510080, Guangdong, Peoples R China
3.St Lukes Episcopal Hosp, Texas Heart Inst, Houston, TX 77030 USA
4.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100083, Peoples R China

Recommended Citation:
Shan, Zhi-Xin,Lin, Qiu-Xiong,Deng, Chun-Yu,et al. miR-1/miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes[J]. FEBS LETTERS,2010,584(16):3592-3600.
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