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学科主题: 基础医学
题名:
An efficient non-iterative algorithm to estimate the apparent diffusion coefficient of water molecules in the magnetic resonance diffusion imaging experiments
作者: Gao, Song1; Wang, Fei1,2; He, Dongqi2; Zhang, Shouyu3; Bao, Shanglian3
关键词: Apparent diffusion coefficient ; Diffusion-weighted imaging ; DWI ; Non-iterative
刊名: CHINESE SCIENCE BULLETIN
发表日期: 2014-03-01
DOI: 10.1007/s11434-013-0015-6
卷: 59, 期:8, 页:734-739
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: HUMAN BRAIN ; WHITE-MATTER ; MODEL
英文摘要:

Many studies have shown that the magnetic resonance signal decay with an extend range of diffusion weighting (b-factor) is a bi-exponential attenuation in the diffusion-weighted magnetic resonance imaging experiments in vivo. Based on this feature and the two-compartmental model, we propose a twice-linear-fitting (TLF) algorithm to estimate the apparent diffusion coefficient (ADC) of the water molecules instead of the commonly used iterative Levenberg-Marquardt (LM) method. The TLF algorithm consists of two liner fitting steps to estimate the fast and the slow apparent diffusion coefficients and their sizes, respectively. It is unnecessary to guess the initial values in the whole fitting process. The time consumption of the TLF algorithm is much less than that of the iterative LM method. Moreover, the TLF algorithm may avoid the extraneous solutions, which often deteriorates the results of the LM method. Compared with the iterative fitting method, the TLF algorithm is a reliable and time-efficient approach to estimate the ADC of water molecules in vivo in magnetic resonance diffusion-weighted imaging experiments.

语种: 英语
所属项目编号: 81171330 ; 7102102
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000331564100004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52811
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Phys, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Biophys, Beijing 100191, Peoples R China
3.Peking Univ, Sch Phys, Med Phys & Engn Lab, Beijing 100875, Peoples R China

Recommended Citation:
Gao, Song,Wang, Fei,He, Dongqi,et al. An efficient non-iterative algorithm to estimate the apparent diffusion coefficient of water molecules in the magnetic resonance diffusion imaging experiments[J]. CHINESE SCIENCE BULLETIN,2014,59(8):734-739.
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