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学科主题: 临床医学
题名:
Gastric cancer: Helicobacter pylori, serum vitamin C, and other risk factors
作者: You, WC1; Zhang, L1; Gail, MH1; Chang, YS1; Liu, WD1; Ma, JL1; Li, JY1; Jin, ML1; Hu, YR1; Yang, CS1; Blaser, MJ1; Correa, P1; Blot, WJ1; Fraumeni, JF1; Xu, GW1
刊名: JOURNAL OF THE NATIONAL CANCER INSTITUTE
发表日期: 2000-10-04
卷: 92, 期:19, 页:1607-1612
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: STOMACH-CANCER ; CHINESE POPULATION ; PRECANCEROUS LESIONS ; INFECTION ; CARCINOMA ; FERRITIN ; PROGRESSION ; ASSOCIATION ; SHANDONG ; COHORT
英文摘要:

Background: Gastric cancer is generally thought to arise through a series of gastric mucosal changes, but the determinants of the precancerous lesions are not well understood. To identify such determinants, me launched a follow-up study in 1989-1990 among 3433 adults in Linqu County, China, a region with very high rates of gastric cancer. Methods: Data on cigarette smoking, alcohol consumption, and other characteristics of the participants were obtained by interview in 1989-1990, when an initial endoscopy was taken. At study entry, antibodies to Helicobacter pylori were assayed in 2646 adults (77% of people screened), and levels of serum micronutrients were measured in approximately 450 adults. Follow-up endoscopic and histopathologic examinations were conducted in 1994. Antibodies to H. pylori, levels of serum micronutrients, and other baseline characteristics were compared between subjects whose condition showed progression to dysplasia or gastric cancer from study entry to 1994 and subjects with no change or with regression of their lesions over the same time frame. All P values are two-sided. Results: The presence of H, pylori at baseline was associated with an increased risk of progression to dysplasia or gastric cancer (odds ratio [OR] = 1.8; 95% confidence interval [CI] = 1.2-2.6). The risk of progression to dysplasia or gastric cancer also was moderately increased with the number of years of cigarette smoking. In contrast, the risk of progression was decreased by 80% (OR = 0.2; 95% CI = 0.1-0.7) among subjects with baseline ascorbic acid levels in the highest tertile compared with those in Conclusions: H. pylori infection, cigarette smoking, and low levels of dietary vitamin C may contribute to the progression of precancerous lesions to gastric cancer in this high-risk population.

语种: 英语
WOS记录号: WOS:000089563300015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52812
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
2.Beijing Med Univ, Beijing Inst Canc Res, Beijing 100083, Peoples R China
3.Beijing Med Univ, Sch Oncol, Beijing 100083, Peoples R China
4.Publ Hlth Bur, Shandong, Peoples R China
5.Westat, Rockville, MD USA
6.Rutgers State Univ, Piscataway, NJ USA
7.Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA
8.Dept Vet Affairs Med Ctr, Nashville, TN 37212 USA
9.Int Epidemiol Inst, Rockville, MD USA
10.Louisiana State Univ, Med Ctr, New Orleans, LA USA

Recommended Citation:
You, WC,Zhang, L,Gail, MH,et al. Gastric cancer: Helicobacter pylori, serum vitamin C, and other risk factors[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE,2000,92(19):1607-1612.
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