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学科主题: 口腔医学
题名:
Preparation and characterization of porous beta-tricalcium phosphate collagen composites with an integrated structure
作者: Zou, C1; Weng, WJ1; Deng, XL1; Cheng, K1; Liu, XG1; Du, PY1; Shen, G1; Han, GR1
关键词: beta-tricalcium phosphate ; collagen ; porous composite ; preparation ; microstructure ; scaffold
刊名: BIOMATERIALS
发表日期: 2005-09-01
DOI: 10.1016/j.biomaterials.2005.01.064
卷: 26, 期:26, 页:5276-5284
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: BONE-TISSUE ; CALCIUM-PHOSPHATE ; IN-VITRO ; SCAFFOLDS ; BIOMATERIALS ; NUCLEATION ; SYSTEM
英文摘要:

Porous beta-tricalcium phosphate (TCP)/collagen composites with different beta-TCP/collagen weight ratio were prepared. The influences of the preparation conditions on the microstructure of porous composite and the joint status of beta-TCP particles with collagen fibrils were characterized by X-ray diffractometer, scanning electron microscopy and transmission electron microscopy. The results showed: (1) an acid treatment could effectively disassemble collagen fibrils; (2) in the resulting porous composites, beta-TCP particles homogenously existed on the skeleton of the collagen fibril network and bonded tightly to both the fibrils and themselves. The tight bonding formation could be due to the reaction between Ca ions in the particles and carboxyl groups in colla-g-en polypeptide chains and due to the reprecipitation of partially dissolved beta-TCP during synthesis. The tight bonding between beta-TCP particles and collagen fibrils in the composites demonstrated an integrated structure, which was reproducible when beta-TCP/collagen ratio ranged from 2 to 4. Such integrated structure would make significant contributions in reliably tailoring properties of the porous composites by varying beta-TCP content. In addition, the porous composites had large porosity (similar to 95%) and appropriate pore size (similar to 100 mu m), showed no negative impact in cytotoxicity assay and complete bone tissue regeneration after 12 weeks in animal test. (c) 2005 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000228844900002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52813
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Beijing Univ, Sch Stomatol, Beijing 100081, Peoples R China
2.Zhejiang Univ, Dept Mat Sci & Engn, Hangzhou 310027, Peoples R China

Recommended Citation:
Zou, C,Weng, WJ,Deng, XL,et al. Preparation and characterization of porous beta-tricalcium phosphate collagen composites with an integrated structure[J]. BIOMATERIALS,2005,26(26):5276-5284.
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