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Preparation and characterization of porous beta-tricalcium phosphate collagen composites with an integrated structure
Zou, C1; Weng, WJ1; Deng, XL1; Cheng, K1; Liu, XG1; Du, PY1; Shen, G1; Han, GR1
关键词Beta-tricalcium Phosphate Collagen Porous Composite Preparation Microstructure Scaffold
刊名BIOMATERIALS
2005-09-01
DOI10.1016/j.biomaterials.2005.01.064
26期:26页:5276-5284
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]BONE-TISSUE ; CALCIUM-PHOSPHATE ; IN-VITRO ; SCAFFOLDS ; BIOMATERIALS ; NUCLEATION ; SYSTEM
英文摘要

Porous beta-tricalcium phosphate (TCP)/collagen composites with different beta-TCP/collagen weight ratio were prepared. The influences of the preparation conditions on the microstructure of porous composite and the joint status of beta-TCP particles with collagen fibrils were characterized by X-ray diffractometer, scanning electron microscopy and transmission electron microscopy. The results showed: (1) an acid treatment could effectively disassemble collagen fibrils; (2) in the resulting porous composites, beta-TCP particles homogenously existed on the skeleton of the collagen fibril network and bonded tightly to both the fibrils and themselves. The tight bonding formation could be due to the reaction between Ca ions in the particles and carboxyl groups in colla-g-en polypeptide chains and due to the reprecipitation of partially dissolved beta-TCP during synthesis. The tight bonding between beta-TCP particles and collagen fibrils in the composites demonstrated an integrated structure, which was reproducible when beta-TCP/collagen ratio ranged from 2 to 4. Such integrated structure would make significant contributions in reliably tailoring properties of the porous composites by varying beta-TCP content. In addition, the porous composites had large porosity (similar to 95%) and appropriate pore size (similar to 100 mu m), showed no negative impact in cytotoxicity assay and complete bone tissue regeneration after 12 weeks in animal test. (c) 2005 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000228844900002
引用统计
被引频次:52[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52813
专题北京大学口腔医学院
作者单位1.Beijing Univ, Sch Stomatol, Beijing 100081, Peoples R China
2.Zhejiang Univ, Dept Mat Sci & Engn, Hangzhou 310027, Peoples R China
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Zou, C,Weng, WJ,Deng, XL,et al. Preparation and characterization of porous beta-tricalcium phosphate collagen composites with an integrated structure[J]. BIOMATERIALS,2005,26(26):5276-5284.
APA Zou, C.,Weng, WJ.,Deng, XL.,Cheng, K.,Liu, XG.,...&Han, GR.(2005).Preparation and characterization of porous beta-tricalcium phosphate collagen composites with an integrated structure.BIOMATERIALS,26(26),5276-5284.
MLA Zou, C,et al."Preparation and characterization of porous beta-tricalcium phosphate collagen composites with an integrated structure".BIOMATERIALS 26.26(2005):5276-5284.
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