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学科主题: 基础医学
题名:
Peroxisome proliferator-activated receptors and renal diseases
作者: Wu, Jing; Chen, Lihong; Zhang, Dongjuan; Huo, Ming; Zhang, Xiaoyan; Pu, Dan; Guan, Youfei
关键词: PPARs ; TZD ; Fibrate ; Renal Disease ; Diabetic Nephropathy ; Renoprotection ; Review
刊名: FRONTIERS IN BIOSCIENCE
发表日期: 2009
DOI: 10.2741/3291
卷: 14, 页:995-1009
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: PPAR-GAMMA AGONISTS ; TYPE-2 DIABETIC-PATIENTS ; HIGH-FAT DIET ; NF-KAPPA-B ; IMPROVES INSULIN SENSITIVITY ; ISCHEMIA-REPERFUSION INJURY ; HEPATOCYTE GROWTH-FACTOR ; MESANGIAL CELLS ; ANGIOTENSIN-II ; GLYCEMIC CONTROL
英文摘要:

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-dependent transcription factors. Three isoforms of PPAR, i.e., PPAR-alpha, -delta, and -gamma, have been identified and are differentially expressed in various tissues, including the kidney. The target genes of PPARs are involved in diverse biological processes, including adipogenesis, lipid metabolism, insulin sensitivity, inflammatory response, reproduction, and cell growth and differentiation. PPARs have been reported to protect against renal injury through indirect systemic effects and/or direct renal effects in diabetic nephropathy, glomerulonephritis, renal cell carcinoma, acute renal failure and chronic renal disease. In this review, we summarize the role of the three identified PPAR isoforms, PPAR alpha, -delta, and -gamma, in renal physiology and discuss the renoprotective effects of PPAR ligands in various kidney diseases.

语种: 英语
所属项目编号: NSFC 30670766 ; 30530340 ; 30725033 ; 2006CB503907
项目资助者: Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000262352400064
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/52814
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: Peking Beijing Univ Hlth Sci Ctr, Peking Beijing Univ Diabet Ctr, Dept Physiol & Pathophysiol, Key Lab Mol Cardiovasc Sci, Beijing 100083, Peoples R China

Recommended Citation:
Wu, Jing,Chen, Lihong,Zhang, Dongjuan,et al. Peroxisome proliferator-activated receptors and renal diseases[J]. FRONTIERS IN BIOSCIENCE,2009,14:995-1009.
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