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学科主题基础医学
Peroxisome proliferator-activated receptors and renal diseases
Wu, Jing; Chen, Lihong; Zhang, Dongjuan; Huo, Ming; Zhang, Xiaoyan; Pu, Dan; Guan, Youfei
关键词Ppars Tzd Fibrate Renal Disease Diabetic Nephropathy Renoprotection Review
刊名FRONTIERS IN BIOSCIENCE
2009
DOI10.2741/3291
14页:995-1009
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]PPAR-GAMMA AGONISTS ; TYPE-2 DIABETIC-PATIENTS ; HIGH-FAT DIET ; NF-KAPPA-B ; IMPROVES INSULIN SENSITIVITY ; ISCHEMIA-REPERFUSION INJURY ; HEPATOCYTE GROWTH-FACTOR ; MESANGIAL CELLS ; ANGIOTENSIN-II ; GLYCEMIC CONTROL
英文摘要

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-dependent transcription factors. Three isoforms of PPAR, i.e., PPAR-alpha, -delta, and -gamma, have been identified and are differentially expressed in various tissues, including the kidney. The target genes of PPARs are involved in diverse biological processes, including adipogenesis, lipid metabolism, insulin sensitivity, inflammatory response, reproduction, and cell growth and differentiation. PPARs have been reported to protect against renal injury through indirect systemic effects and/or direct renal effects in diabetic nephropathy, glomerulonephritis, renal cell carcinoma, acute renal failure and chronic renal disease. In this review, we summarize the role of the three identified PPAR isoforms, PPAR alpha, -delta, and -gamma, in renal physiology and discuss the renoprotective effects of PPAR ligands in various kidney diseases.

语种英语
WOS记录号WOS:000262352400064
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/52814
专题北京大学基础医学院_心血管所
北京大学基础医学院
北京大学第二临床医学院_风湿免疫科
北京大学第二临床医学院_内分泌科
作者单位Peking Beijing Univ Hlth Sci Ctr, Peking Beijing Univ Diabet Ctr, Dept Physiol & Pathophysiol, Key Lab Mol Cardiovasc Sci, Beijing 100083, Peoples R China
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GB/T 7714
Wu, Jing,Chen, Lihong,Zhang, Dongjuan,et al. Peroxisome proliferator-activated receptors and renal diseases[J]. FRONTIERS IN BIOSCIENCE,2009,14:995-1009.
APA Wu, Jing.,Chen, Lihong.,Zhang, Dongjuan.,Huo, Ming.,Zhang, Xiaoyan.,...&Guan, Youfei.(2009).Peroxisome proliferator-activated receptors and renal diseases.FRONTIERS IN BIOSCIENCE,14,995-1009.
MLA Wu, Jing,et al."Peroxisome proliferator-activated receptors and renal diseases".FRONTIERS IN BIOSCIENCE 14(2009):995-1009.
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